ZA881962B - 19,11beta-bridged steriods,their manufacture and pharmaceutical preparations containing them - Google Patents
19,11beta-bridged steriods,their manufacture and pharmaceutical preparations containing themInfo
- Publication number
- ZA881962B ZA881962B ZA881962A ZA881962A ZA881962B ZA 881962 B ZA881962 B ZA 881962B ZA 881962 A ZA881962 A ZA 881962A ZA 881962 A ZA881962 A ZA 881962A ZA 881962 B ZA881962 B ZA 881962B
- Authority
- ZA
- South Africa
- Prior art keywords
- radical
- hydrogen atom
- alkyl radical
- image
- bond
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- -1 C1-C4-alkyl radical Chemical class 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0063—Nitrogen and oxygen at position 2(3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873708942 DE3708942A1 (de) | 1987-03-18 | 1987-03-18 | 19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA881962B true ZA881962B (en) | 1988-09-08 |
Family
ID=6323462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA881962A ZA881962B (en) | 1987-03-18 | 1988-03-18 | 19,11beta-bridged steriods,their manufacture and pharmaceutical preparations containing them |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5095129A (cs) |
| EP (1) | EP0283428B1 (cs) |
| JP (1) | JP2588267B2 (cs) |
| CN (3) | CN1033033C (cs) |
| AT (1) | ATE69055T1 (cs) |
| AU (1) | AU628015B2 (cs) |
| CA (1) | CA1326015C (cs) |
| DD (1) | DD273262A5 (cs) |
| DE (2) | DE3708942A1 (cs) |
| ES (1) | ES2040373T3 (cs) |
| FI (1) | FI101883B1 (cs) |
| GR (1) | GR3003362T3 (cs) |
| HU (2) | HU206368B (cs) |
| IE (1) | IE62480B1 (cs) |
| IL (1) | IL85773A (cs) |
| NZ (1) | NZ223924A (cs) |
| PT (1) | PT87007B (cs) |
| WO (1) | WO1988007051A1 (cs) |
| ZA (1) | ZA881962B (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0360369A1 (de) * | 1988-09-20 | 1990-03-28 | Schering Aktiengesellschaft | 11Beta-phenyl-14betaH-steroide |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5446178A (en) * | 1987-03-18 | 1995-08-29 | Schering Aktiengesellschaft | Process for preparing 19,11β-bridged steroids |
| DE3917274A1 (de) * | 1989-05-24 | 1990-11-29 | Schering Ag | 9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE3921059A1 (de) * | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
| DD289541A5 (de) * | 1989-08-04 | 1991-05-02 | ��@�K@�������������@�K@��������������@��������k�� | Verfahren zur herstellung von 11beta-aryl-16 alpha, 17 alph-cyclohexanoestra-4,9-dienen |
| DE4038128A1 (de) * | 1990-11-27 | 1992-06-04 | Schering Ag | 8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
| US5439913A (en) * | 1992-05-12 | 1995-08-08 | Schering Aktiengesellschaft | Contraception method using competitive progesterone antagonists and novel compounds useful therein |
| DE4235220A1 (de) * | 1992-10-13 | 1994-06-16 | Schering Ag | Gestagen wirksame 19,11ß-überbrückte 4-Estrene |
| DE4413184A1 (de) * | 1994-04-12 | 1995-10-19 | Schering Ag | 10,11-C¶3¶-überbrückte Steroide |
| DE4413185A1 (de) * | 1994-04-12 | 1995-10-19 | Schering Ag | 11beta,19-überbrückte 13alpha-Alkylsteroide |
| DE4417880A1 (de) * | 1994-05-18 | 1995-11-23 | Schering Ag | 19,11beta-Überbrückte 18-Nor-Steroide, Verfahren zu ihrer Herstellung, diese Steroide enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln |
| US5639598A (en) * | 1994-05-19 | 1997-06-17 | The Trustees Of The University Of Pennsylvania | Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions |
| US5780220A (en) * | 1994-05-19 | 1998-07-14 | Trustees Of The University Of Pennsylvania | Methods and compositions for inhibiting HIV replication |
| DE4424222C1 (de) * | 1994-07-09 | 1995-09-14 | Metallgesellschaft Ag | Gelöstes Methyllithium enthaltendes Synthesemittel sowie Verfahren zu deren Herstellung |
| DE4434488A1 (de) | 1994-09-14 | 1996-03-21 | Schering Ag | Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| US5521166A (en) * | 1994-12-19 | 1996-05-28 | Ortho Pharmaceitical Corporation | Antiprogestin cyclophasic hormonal regimen |
| ZA9510926B (en) | 1994-12-23 | 1996-07-03 | Schering Ag | Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception |
| IL118974A (en) * | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| DE19652408C2 (de) * | 1996-12-06 | 2002-04-18 | Schering Ag | Steroidester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln |
| US6090798A (en) * | 1997-12-19 | 2000-07-18 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with glucocorticoid antagonists |
| GB0000313D0 (en) | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
| HUE051484T2 (hu) | 2006-10-24 | 2021-03-01 | Allergan Pharmaceuticals Int Ltd | Készítmények és eljárások az endometriális proliferációk elnyomására |
| TWI539953B (zh) | 2008-04-28 | 2016-07-01 | 瑞波若斯治療學公司 | 用於治療乳癌之組成物和方法 |
| WO2011119194A1 (en) | 2010-03-22 | 2011-09-29 | Repros Therapeutics Inc. | Compositions and methods for non-toxic delivery of antiprogestins |
| WO2011150209A1 (en) | 2010-05-26 | 2011-12-01 | Corcept Therapeutics, Inc. | Treatment of muscular dystrophy |
| CN103555806B (zh) * | 2013-11-16 | 2015-05-13 | 江南大学 | 一种高效利用亚麻刺盘孢霉合成7α-羟基-雄甾烯酮的方法 |
| WO2016140867A1 (en) | 2015-03-02 | 2016-09-09 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonist and somatostatin analogues to treat acth-secreting tumors |
| JP6754533B2 (ja) | 2015-03-30 | 2020-09-16 | コーセプト セラピューティクス， インコーポレイテッド | 副腎機能不全を処置するための糖質コルチコイドと組み合わせた糖質コルチコイドレセプターアンタゴニストの使用 |
| KR20180052120A (ko) | 2015-08-13 | 2018-05-17 | 코어셉트 쎄라퓨틱스, 잉크. | Acth-의존성 쿠싱 증후군을 감별 진단하는 방법 |
| CA3011728A1 (en) | 2016-01-19 | 2017-07-27 | Corcept Therapeutics, Inc. | Differential diagnosis of ectopic cushing's syndrome |
| MX2019011543A (es) | 2017-03-31 | 2019-12-16 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides para el tratamiento de cancer cervical. |
| CA3065555A1 (en) | 2017-06-20 | 2018-12-27 | Corcept Therapeutics, Inc. | Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators |
| AU2021400069A1 (en) | 2020-12-18 | 2023-07-06 | Instil Bio (Uk) Limited | Processing of tumor infiltrating lymphocytes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
| FR2522328B1 (fr) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
| FR2576025B1 (fr) * | 1985-01-14 | 1987-01-23 | Roussel Uclaf | Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant |
-
1987
- 1987-03-18 DE DE19873708942 patent/DE3708942A1/de not_active Withdrawn
-
1988
- 1988-03-11 HU HU911518A patent/HU206368B/hu not_active IP Right Cessation
- 1988-03-11 WO PCT/DE1988/000150 patent/WO1988007051A1/de not_active Ceased
- 1988-03-11 ES ES198888730061T patent/ES2040373T3/es not_active Expired - Lifetime
- 1988-03-11 AU AU14209/88A patent/AU628015B2/en not_active Ceased
- 1988-03-11 AT AT88730061T patent/ATE69055T1/de not_active IP Right Cessation
- 1988-03-11 EP EP88730061A patent/EP0283428B1/de not_active Expired - Lifetime
- 1988-03-11 DE DE88730061T patent/DE3865863D1/de not_active Expired - Lifetime
- 1988-03-11 JP JP63502319A patent/JP2588267B2/ja not_active Expired - Fee Related
- 1988-03-17 NZ NZ223924A patent/NZ223924A/en unknown
- 1988-03-17 DD DD88313750A patent/DD273262A5/de not_active IP Right Cessation
- 1988-03-17 CA CA000561771A patent/CA1326015C/en not_active Expired - Fee Related
- 1988-03-17 IL IL8577388A patent/IL85773A/en not_active IP Right Cessation
- 1988-03-18 IE IE79388A patent/IE62480B1/en not_active IP Right Cessation
- 1988-03-18 CN CN88102162A patent/CN1033033C/zh not_active Expired - Fee Related
- 1988-03-18 ZA ZA881962A patent/ZA881962B/xx unknown
- 1988-03-18 PT PT87007A patent/PT87007B/pt not_active IP Right Cessation
- 1988-12-09 US US07/283,632 patent/US5095129A/en not_active Expired - Fee Related
-
1989
- 1989-09-15 FI FI894364A patent/FI101883B1/fi not_active IP Right Cessation
-
1991
- 1991-12-17 GR GR91401682T patent/GR3003362T3/el unknown
-
1994
- 1994-07-11 HU HU94P/P00010P patent/HU210532A9/hu unknown
-
1996
- 1996-01-17 CN CN96100917A patent/CN1057770C/zh not_active Expired - Fee Related
- 1996-02-01 CN CN96102566A patent/CN1080267C/zh not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0360369A1 (de) * | 1988-09-20 | 1990-03-28 | Schering Aktiengesellschaft | 11Beta-phenyl-14betaH-steroide |
| WO1990003385A1 (de) * | 1988-09-20 | 1990-04-05 | Schering Aktiengesellschaft Berlin Und Bergkamen | 11β-PHENYL-14βH-STEROIDE |
Also Published As
| Publication number | Publication date |
|---|---|
| PT87007A (pt) | 1988-04-01 |
| NZ223924A (en) | 1991-12-23 |
| CA1326015C (en) | 1994-01-11 |
| HU206368B (en) | 1992-10-28 |
| FI894364A0 (fi) | 1989-09-15 |
| ES2040373T3 (es) | 1993-10-16 |
| IL85773A (en) | 1994-01-01 |
| PT87007B (pt) | 1992-06-30 |
| GR3003362T3 (en) | 1993-02-17 |
| IL85773A0 (en) | 1988-09-30 |
| DE3708942A1 (de) | 1988-09-29 |
| AU1420988A (en) | 1988-10-10 |
| CN1141926A (zh) | 1997-02-05 |
| CN1135488A (zh) | 1996-11-13 |
| CN88102162A (zh) | 1988-11-23 |
| ATE69055T1 (de) | 1991-11-15 |
| FI101883B (fi) | 1998-09-15 |
| HU210532A9 (en) | 1995-04-28 |
| DE3865863D1 (cs) | 1991-12-05 |
| US5095129A (en) | 1992-03-10 |
| FI101883B1 (fi) | 1998-09-15 |
| CN1033033C (zh) | 1996-10-16 |
| WO1988007051A1 (fr) | 1988-09-22 |
| JP2588267B2 (ja) | 1997-03-05 |
| IE62480B1 (en) | 1995-02-08 |
| DD273262A5 (de) | 1989-11-08 |
| CN1057770C (zh) | 2000-10-25 |
| HU911518D0 (en) | 1991-11-28 |
| EP0283428B1 (de) | 1991-10-30 |
| AU628015B2 (en) | 1992-09-10 |
| JPH02503194A (ja) | 1990-10-04 |
| IE880793L (en) | 1988-09-18 |
| EP0283428A1 (de) | 1988-09-21 |
| CN1080267C (zh) | 2002-03-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA881962B (en) | 19,11beta-bridged steriods,their manufacture and pharmaceutical preparations containing them | |
| DE69021176D1 (de) | Polypeptid und Verfahren zu dessen Herstellung. | |
| NO912347L (no) | Fremgangsmaate for fremstilling av nye polypeptider. | |
| TW351714B (en) | New vitamin D derivatives with substituents at C-25, process for their production, intermediate products and use for the production of pharmaceutical agents | |
| AU1178588A (en) | New 19-norsteroids substituted at the 7-position, their preparation, their application as drugs and the pharmaceutical compositions containing them | |
| HUP9702509A2 (hu) | Kondenzált heterociklusos vegyületek aminocsoportjukon szubsztituált származékai, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
| DK96783D0 (da) | Fremgangsmade til fremstilling af 4''-epierythromycin a eller derivater deraf | |
| TW249804B (cs) | ||
| ES8705891A1 (es) | Un procedimiento para preparar antibioticos de cefalosporina. | |
| HUT50142A (en) | Process for producing allyl-mercapto-acetyl-sidnonimine derivatives and pharmaceutical compositions containing them | |
| ES8205224A1 (es) | Un procedimiento para la preparacion de acidos 1-carbadetiapen-2-em-3-carboxilios 6-1-y 2-sustituidos. | |
| NO960425D0 (no) | 15,15-dialkyl-substituerte derivater av östradiol | |
| EP0312773A3 (en) | Substituted 3-aminosydnonimines, process for their preparation and their use | |
| ES8101074A1 (es) | Procedimiento para la preparacion de derivados de xantina | |
| EP0367036A3 (en) | Substituted 3-aminosydnonimines, process for their preparation and their use | |
| FI951834L (fi) | 19,11 -sillan käsittäviä steroideja | |
| IE812732L (en) | 3-amino steroid compounds | |
| HK1005881A1 (en) | Pregna-1,4-diene-3,20-dione-16-17-acetal-21 esters | |
| ATE130309T1 (de) | 14alpha,16alpha-ethano- und 14alpha,16alpha- ethenoestratriene. | |
| FI921238A7 (fi) | Välituotteina käytettävät N'-alkoksi- tai N'-aralkyylioksi-N6-syano-griseoliinihapon johdannaiset |