ES2040373T3 - Esteroides puenteados en 19,11beta, su preparacion y preparados farmaceuticos que contienen estos compuestos. - Google Patents

Esteroides puenteados en 19,11beta, su preparacion y preparados farmaceuticos que contienen estos compuestos.

Info

Publication number
ES2040373T3
ES2040373T3 ES198888730061T ES88730061T ES2040373T3 ES 2040373 T3 ES2040373 T3 ES 2040373T3 ES 198888730061 T ES198888730061 T ES 198888730061T ES 88730061 T ES88730061 T ES 88730061T ES 2040373 T3 ES2040373 T3 ES 2040373T3
Authority
ES
Spain
Prior art keywords
radical
hydrogen atom
alkyl radical
image
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888730061T
Other languages
English (en)
Inventor
Eckhard Dr. Ottow
Rudolf Prof. Dr. Wiechert
Gunter Dr. Neef
Sybille Dr. Beier
Walter Dr. Elger
David Andrew Dr. Henderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2040373T3 publication Critical patent/ES2040373T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0063—Nitrogen and oxygen at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • External Artificial Organs (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DECSRIBEN NUEVOS ESTEROIDES PUENTEADOS EN 19,11 BETA DE FORMULA GENERAL (I) DONDE R1, R2, B, G, Z, V Y A TIENEN EL SIGNIFICADO QUE SE INDICA EN LA DESCRIPCION. SE DESCRIBEN TAMBIEN SUS SALES FARMACOLOGICAMENTE ACEPTABLES. LOS NUEVOS COMPUESTOS POSEEN VALIOSAS PROPIEDADES FARMACOLOGICAS.
ES198888730061T 1987-03-18 1988-03-11 Esteroides puenteados en 19,11beta, su preparacion y preparados farmaceuticos que contienen estos compuestos. Expired - Lifetime ES2040373T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873708942 DE3708942A1 (de) 1987-03-18 1987-03-18 19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate

Publications (1)

Publication Number Publication Date
ES2040373T3 true ES2040373T3 (es) 1993-10-16

Family

ID=6323462

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888730061T Expired - Lifetime ES2040373T3 (es) 1987-03-18 1988-03-11 Esteroides puenteados en 19,11beta, su preparacion y preparados farmaceuticos que contienen estos compuestos.

Country Status (19)

Country Link
US (1) US5095129A (es)
EP (1) EP0283428B1 (es)
JP (1) JP2588267B2 (es)
CN (3) CN1033033C (es)
AT (1) ATE69055T1 (es)
AU (1) AU628015B2 (es)
CA (1) CA1326015C (es)
DD (1) DD273262A5 (es)
DE (2) DE3708942A1 (es)
ES (1) ES2040373T3 (es)
FI (1) FI101883B1 (es)
GR (1) GR3003362T3 (es)
HU (2) HU206368B (es)
IE (1) IE62480B1 (es)
IL (1) IL85773A (es)
NZ (1) NZ223924A (es)
PT (1) PT87007B (es)
WO (1) WO1988007051A1 (es)
ZA (1) ZA881962B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446178A (en) * 1987-03-18 1995-08-29 Schering Aktiengesellschaft Process for preparing 19,11β-bridged steroids
DE3832303A1 (de) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide
DE3917274A1 (de) * 1989-05-24 1990-11-29 Schering Ag 9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
DD289541A5 (de) * 1989-08-04 1991-05-02 ��@�K@�������������@�K@��������������@��������k�� Verfahren zur herstellung von 11beta-aryl-16 alpha, 17 alph-cyclohexanoestra-4,9-dienen
DE4038128A1 (de) * 1990-11-27 1992-06-04 Schering Ag 8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
US5439913A (en) * 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
DE4235220A1 (de) * 1992-10-13 1994-06-16 Schering Ag Gestagen wirksame 19,11ß-überbrückte 4-Estrene
DE4413184A1 (de) * 1994-04-12 1995-10-19 Schering Ag 10,11-C¶3¶-überbrückte Steroide
DE4413185A1 (de) * 1994-04-12 1995-10-19 Schering Ag 11beta,19-überbrückte 13alpha-Alkylsteroide
DE4417880A1 (de) * 1994-05-18 1995-11-23 Schering Ag 19,11beta-Überbrückte 18-Nor-Steroide, Verfahren zu ihrer Herstellung, diese Steroide enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
DE4424222C1 (de) * 1994-07-09 1995-09-14 Metallgesellschaft Ag Gelöstes Methyllithium enthaltendes Synthesemittel sowie Verfahren zu deren Herstellung
DE4434488A1 (de) 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5521166A (en) * 1994-12-19 1996-05-28 Ortho Pharmaceitical Corporation Antiprogestin cyclophasic hormonal regimen
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
DE19652408C2 (de) * 1996-12-06 2002-04-18 Schering Ag Steroidester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln
US6090798A (en) * 1997-12-19 2000-07-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with glucocorticoid antagonists
GB0000313D0 (en) * 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
CA2673128C (en) 2006-10-24 2018-07-03 Repros Therapeutics Inc. Compositions and methods for suppressing endometrial proliferation
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
CN102906103A (zh) 2010-03-22 2013-01-30 利普生物药剂公司 用于抗孕酮的非毒性递送的组合物和方法
US11103514B2 (en) 2010-05-26 2021-08-31 Corcept Therapeutics, Inc. Treatment of muscular dystrophy
CN103555806B (zh) * 2013-11-16 2015-05-13 江南大学 一种高效利用亚麻刺盘孢霉合成7α-羟基-雄甾烯酮的方法
EP3265127B1 (en) 2015-03-02 2024-02-21 Corcept Therapeutics, Inc. Mifepristone and octreotide for use in the treatment of cushing's syndrome in a patient having an adrenocorticotropic hormone (acth)-secreting pancreatic neuroendocrine tumor
ES2906778T3 (es) 2015-03-30 2022-04-20 Corcept Therapeutics Inc Uso de antagonistas del receptor de glucocorticoides en combinación con glucocorticoides para tratar la insuficiencia suprarrenal
JP6768789B2 (ja) 2015-08-13 2020-10-14 コーセプト セラピューティクス， インコーポレイテッド Ａｃｔｈ依存性クッシング症候群を鑑別診断する方法
EP3405101B1 (en) 2016-01-19 2020-12-23 Corcept Therapeutics, Inc. Differential diagnosis of ectopic cushing's syndrome
EP3641780A4 (en) 2017-06-20 2021-02-24 Corcept Therapeutics, Inc. TREATMENT METHODS OF NEURO-EPITHELIAL TUMORS USING SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS
EP4263807A2 (en) 2020-12-18 2023-10-25 Instil Bio (Uk) Limited Processing of tumor infiltrating lymphocytes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
CN1080267C (zh) 2002-03-06
AU1420988A (en) 1988-10-10
IE880793L (en) 1988-09-18
EP0283428A1 (de) 1988-09-21
DD273262A5 (de) 1989-11-08
HU210532A9 (en) 1995-04-28
IL85773A0 (en) 1988-09-30
DE3708942A1 (de) 1988-09-29
US5095129A (en) 1992-03-10
PT87007B (pt) 1992-06-30
NZ223924A (en) 1991-12-23
DE3865863D1 (es) 1991-12-05
CN1057770C (zh) 2000-10-25
ATE69055T1 (de) 1991-11-15
FI101883B (fi) 1998-09-15
IL85773A (en) 1994-01-01
CN1135488A (zh) 1996-11-13
ZA881962B (en) 1988-09-08
EP0283428B1 (de) 1991-10-30
WO1988007051A1 (en) 1988-09-22
CN1141926A (zh) 1997-02-05
JP2588267B2 (ja) 1997-03-05
HU911518D0 (en) 1991-11-28
IE62480B1 (en) 1995-02-08
JPH02503194A (ja) 1990-10-04
CA1326015C (en) 1994-01-11
PT87007A (pt) 1988-04-01
GR3003362T3 (en) 1993-02-17
CN1033033C (zh) 1996-10-16
HU206368B (en) 1992-10-28
AU628015B2 (en) 1992-09-10
CN88102162A (zh) 1988-11-23
FI894364A0 (fi) 1989-09-15
FI101883B1 (fi) 1998-09-15

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