ZA867347B - Medicaments to combat chronic graft-versus-host diseases and to combat autoimmune diseases,in particular systemic lupus erythematosus - Google Patents

Medicaments to combat chronic graft-versus-host diseases and to combat autoimmune diseases,in particular systemic lupus erythematosus

Info

Publication number
ZA867347B
ZA867347B ZA867347A ZA867347A ZA867347B ZA 867347 B ZA867347 B ZA 867347B ZA 867347 A ZA867347 A ZA 867347A ZA 867347 A ZA867347 A ZA 867347A ZA 867347 B ZA867347 B ZA 867347B
Authority
ZA
South Africa
Prior art keywords
combat
medicaments
diseases
versus
lupus erythematosus
Prior art date
Application number
ZA867347A
Other languages
English (en)
Inventor
Robert R Bartlett
Rudolf Schleyerbach
Friedrich-Johannes Kaemmerer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA867347B publication Critical patent/ZA867347B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
ZA867347A 1985-09-27 1986-09-26 Medicaments to combat chronic graft-versus-host diseases and to combat autoimmune diseases,in particular systemic lupus erythematosus ZA867347B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853534440 DE3534440A1 (de) 1985-09-27 1985-09-27 Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes

Publications (1)

Publication Number Publication Date
ZA867347B true ZA867347B (en) 1987-05-27

Family

ID=6282084

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA867347A ZA867347B (en) 1985-09-27 1986-09-26 Medicaments to combat chronic graft-versus-host diseases and to combat autoimmune diseases,in particular systemic lupus erythematosus

Country Status (11)

Country Link
US (1) US4965276A (xx)
EP (2) EP0217206B1 (xx)
JP (3) JP2514190B2 (xx)
AT (1) ATE122033T1 (xx)
AU (1) AU588629B2 (xx)
CA (1) CA1275251C (xx)
DE (3) DE3534440A1 (xx)
ES (1) ES2001996A6 (xx)
IE (1) IE61232B1 (xx)
IL (1) IL80149A (xx)
ZA (1) ZA867347B (xx)

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US5268382A (en) * 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
US4975462A (en) * 1988-07-29 1990-12-04 Bristol-Myers Company Antiarthritic α-arylcarbamoyl cyanoacetic acid derivatives
DD297328A5 (de) * 1989-08-18 1992-01-09 �������@���������k���Kk�� 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen
US5583150A (en) * 1989-08-18 1996-12-10 Alcon Laboratories, Inc. 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases
US5268389A (en) * 1989-10-16 1993-12-07 Uniroyal Chemical Company, Inc. Thiocarboxylate ester compounds compositions containing the same
US5108999A (en) * 1990-02-02 1992-04-28 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
KR100188801B1 (ko) * 1990-05-18 1999-06-01 엥겔하르트 라피체 이속사졸-4카복스아미드 및 하이드록시알킬리덴 시아노아세트아미드 및 이들 화합물을 함유하는 약제학적 조성물
US6133301A (en) * 1991-08-22 2000-10-17 Aventis Pharma Deutschland Gmbh Pharmaceuticals for the treatment of rejection reactions in organ transplantations
DE4127737A1 (de) * 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
ES2079765T3 (es) * 1991-10-23 1996-01-16 Hoechst Ag Derivados de amidas de acido n-fenil-2-ciano-3-hidroxicrotonico y su utilizacion como medicamento con propiedad inmunomoduladora.
GB9200275D0 (en) * 1992-01-08 1992-02-26 Roussel Lab Ltd Chemical compounds
GB9300083D0 (en) 1993-01-05 1993-03-03 Roussel Lab Ltd Chemical compounds
EP0607777B1 (de) * 1993-01-08 1998-12-09 Hoechst Aktiengesellschaft Verwendung von Leflunomid zur Hemmung von Interleukin 8
EP0607776B1 (de) * 1993-01-08 1998-12-09 Hoechst Aktiengesellschaft Verwendung von Leflunomid zur Hemmung von Tumornekrosefaktor alpha
ES2124799T3 (es) * 1993-01-08 1999-02-16 Hoechst Ag Empleo de leflunomida para la inhibicion de interleuquina 1 alfa.
DK0607775T3 (da) * 1993-01-08 1999-08-16 Hoechst Ag Anvendelse af leflunomid til inhibering af interleukin 1 beta
TW314467B (xx) * 1993-03-31 1997-09-01 Hoechst Ag
WO1994024095A1 (en) * 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
LT3589B (en) 1993-11-30 1995-12-27 Hoechst Ag Using of known combination for treatment of rejection reaction by transplantation of organs
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
US5624946A (en) * 1994-07-05 1997-04-29 Williams; James Use of leflunomide to control and reverse chronic allograft rejection
AU695907B2 (en) * 1994-10-17 1998-08-27 Hoechst Pharmaceuticals & Chemicals K.K. Pharmaceutical composition for prophylaxis and treatment of type I allergic diseases
DE19610955A1 (de) * 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
DE19612131A1 (de) * 1996-03-27 1998-01-22 Hoechst Ag Feste Arzneistoffzubereitung, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl) -anilid
US6011051A (en) * 1996-07-31 2000-01-04 Hoechst Aktiengesellschaft Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
DE19702988A1 (de) * 1997-01-28 1998-07-30 Hoechst Ag Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
US7691890B2 (en) 1998-03-11 2010-04-06 James W. Williams Anti-viral uses of leflunomide products
US20050255071A1 (en) * 1998-12-10 2005-11-17 Aventis Pharma Deutschland Gmbh Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors
DE19908527C2 (de) 1999-02-26 2001-08-30 Aventis Pharma Gmbh Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid
DE19960443C2 (de) * 1999-12-15 2002-05-08 Aventis Pharma Gmbh Verfahren zur Auffindung von Nukleotidsyntheseinhibitoren mit weniger Nebenwirkungen
CA2397601A1 (en) * 1999-12-16 2001-06-21 Teva Pharmaceutical Industries, Ltd. Novel processes for making- and a new crystalline form of- leflunomide
EP1935416A3 (en) 2001-04-05 2008-10-22 Aventis Pharma Inc (Z) -2-cyano-3-hydroxybut-2-enoic acid (4'-trifluoromethylphenyl) amide for the treatment of multiple sclerosis
GB0123571D0 (en) 2001-04-05 2001-11-21 Aventis Pharm Prod Inc Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
WO2003006424A1 (en) 2001-07-10 2003-01-23 4Sc Ag Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
CN1732147A (zh) 2002-12-23 2006-02-08 4Sc股份公司 作为抗炎、免疫调节和抗增殖试剂的环烯二羧酸化合物
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
US20060024376A1 (en) * 2004-07-30 2006-02-02 The University Of Chicago Methods and compositions for reducing toxicity associated with leflunomide treatment
CN104666272A (zh) 2009-09-18 2015-06-03 赛诺菲 稳定性提高的(z)-2-氰基-3-羟基-丁-2-烯酸-(4’-三氟甲基苯基)-酰胺片剂制剂
WO2011116091A1 (en) 2010-03-17 2011-09-22 Novartis Ag Dispenser
UA108760C2 (uk) 2010-07-01 2015-06-10 Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби
CN105395539A (zh) * 2014-08-21 2016-03-16 欣凯医药化工中间体（上海）有限公司 泰瑞米特钠在制备治疗自身免疫病药物中的应用
WO2017056104A1 (en) 2015-09-28 2017-04-06 Natco Pharma Limited Stable pharmaceutical compositions of teriflunomide
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
KR20200131249A (ko) 2018-03-16 2020-11-23 이뮤닉 아게 항-염증제, 면역조절제 및 항-증식제로서의 신규한 칼슘 염 다형체
US11376232B2 (en) 2020-04-21 2022-07-05 Immunic Ag Vidofludimus for use in the treatment or prevention of viral diseases

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NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DK545976A (da) * 1975-12-11 1977-06-12 Hoechst Ag Cyaneddikesyreanilidderivater fremgangsmade til deres fremstilling og midler der indeholder disse forbindelser
DE2555789A1 (de) * 1975-12-11 1977-07-07 Hoechst Ag Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
DE2854439A1 (de) * 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
EP0043150A1 (en) * 1980-06-24 1982-01-06 Akzo N.V. Pharmaceutical 2,3 -bis-hydroxybenzyl butane derivatives
US4435407A (en) * 1982-01-07 1984-03-06 Ciba-Geigy Corporation Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles
US4435387A (en) * 1982-10-25 1984-03-06 American Cyanamid Company Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives
DE3405727A1 (de) * 1984-02-17 1985-08-22 Hoechst Ag, 6230 Frankfurt Isoxazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
AU588629B2 (en) 1989-09-21
ES2001996A6 (es) 1988-07-01
JPS6272614A (ja) 1987-04-03
AU6316786A (en) 1987-04-02
EP0559238A1 (de) 1993-09-08
EP0217206A2 (de) 1987-04-08
US4965276A (en) 1990-10-23
EP0217206A3 (en) 1989-06-14
DE3689252D1 (de) 1993-12-09
EP0559238B1 (de) 1995-05-03
EP0217206B1 (de) 1993-11-03
IL80149A (en) 1990-11-29
CA1275251C (en) 1990-10-16
IE862554L (en) 1987-03-27
DE3534440A1 (de) 1987-04-02
IE61232B1 (en) 1994-10-19
JP2514190B2 (ja) 1996-07-10
ATE122033T1 (de) 1995-05-15
JPH0729918B2 (ja) 1995-04-05
DE3650315D1 (de) 1995-06-08
JPH05208908A (ja) 1993-08-20
JPH07165694A (ja) 1995-06-27
JP2607848B2 (ja) 1997-05-07

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