ZA864444B - Pyrrolidone derivatives - Google Patents

Pyrrolidone derivatives

Info

Publication number
ZA864444B
ZA864444B ZA864444A ZA864444A ZA864444B ZA 864444 B ZA864444 B ZA 864444B ZA 864444 A ZA864444 A ZA 864444A ZA 864444 A ZA864444 A ZA 864444A ZA 864444 B ZA864444 B ZA 864444B
Authority
ZA
South Africa
Prior art keywords
pyrrolidone derivatives
branched
alkyl
hydrogen
straight
Prior art date
Application number
ZA864444A
Other languages
English (en)
Inventor
Mario Pinza
Ugo Pfeiffer
Carlo Farina
Silvano Banfi
Original Assignee
Isf Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isf Spa filed Critical Isf Spa
Publication of ZA864444B publication Critical patent/ZA864444B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
ZA864444A 1985-06-21 1986-06-13 Pyrrolidone derivatives ZA864444B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21234/85A IT1190378B (it) 1985-06-21 1985-06-21 Derivati pirrolidonici

Publications (1)

Publication Number Publication Date
ZA864444B true ZA864444B (en) 1987-02-25

Family

ID=11178795

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA864444A ZA864444B (en) 1985-06-21 1986-06-13 Pyrrolidone derivatives

Country Status (20)

Country Link
US (1) US4824861A (hu)
EP (1) EP0207681B1 (hu)
JP (1) JPS62461A (hu)
KR (1) KR930006766B1 (hu)
AT (1) ATE73821T1 (hu)
AU (1) AU587258B2 (hu)
CA (1) CA1284248C (hu)
DE (1) DE3684368D1 (hu)
DK (1) DK290286A (hu)
ES (2) ES8800164A1 (hu)
FI (1) FI82446C (hu)
GR (1) GR861577B (hu)
HU (1) HU196225B (hu)
IL (1) IL79136A (hu)
IT (1) IT1190378B (hu)
NO (1) NO168428C (hu)
NZ (1) NZ216550A (hu)
PH (1) PH22851A (hu)
PT (2) PT82815B (hu)
ZA (1) ZA864444B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1209644B (it) * 1985-06-21 1989-08-30 Isf Spa Composti farmacologicamente attivi.
DK356288A (da) * 1987-07-30 1989-01-31 Lonza Ag Fremgangsmaade til fremstilling af n-((4-hydroxy-pyrrolidin-2-on-1-yl)-acetyl)-glycinamid
NZ232112A (en) * 1989-01-17 1992-07-28 Hoffmann La Roche ((5-oxo-2-pyrrolidinyl)methyl)cyclohexaneacetamides, intermediates therefor and pharmaceutical compositions
CH680293A5 (hu) * 1990-06-26 1992-07-31 Lonza Ag
US6229011B1 (en) * 1997-08-22 2001-05-08 Hoffman-La Roche Inc. N-aroylphenylalanine derivative VCAM-1 inhibitors
EP1154987B1 (en) 1999-02-18 2004-04-21 F. Hoffmann-La Roche Ag Phenylalaninol derivatives
BR0008280A (pt) 1999-02-18 2001-11-06 Hoffmann La Roche Derivados de tioamida
WO2009145839A1 (en) * 2008-04-04 2009-12-03 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Polyamine compounds that bind tar rna of hiv and methods of treating viral disorders
CN101914052B (zh) * 2010-08-02 2012-06-27 胡建荣 一种奥拉西坦化合物的制备方法
CN102351770B (zh) * 2011-08-12 2012-07-04 江西新先锋医药有限公司 一种奥拉西坦化合物及其药物组合物
CN112724062B (zh) * 2021-01-19 2022-03-15 江苏诚信药业有限公司 一种奥拉西坦杂质b的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH470396A (de) * 1963-08-12 1969-03-31 Hoffmann La Roche Verfahren zur Herstellung von 4-Imidazolidon-Verbindungen
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
AT360980B (de) * 1976-01-14 1981-02-10 Pliva Pharm & Chem Works Verfahren zur herstellung von n-alkylamiden des 2-oxo-1-pyrrolidins
YU39660B (en) * 1976-01-14 1985-03-20 Pliva Pharm & Chem Works Process for obtaining 2-oxo-1-pyrrolidine acetamide
GB1539817A (en) * 1976-10-22 1979-02-07 Ucb Sa N-substituted lactams
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
EP0115473A3 (de) * 1983-01-27 1987-01-21 Ciba-Geigy Ag Substituierte Pyrrolidinonderivate und Verfahren zu ihrer Herstellung
IT1209644B (it) * 1985-06-21 1989-08-30 Isf Spa Composti farmacologicamente attivi.
JPH0681502B2 (ja) * 1988-07-14 1994-10-12 富士通電装株式会社 並列運転保護回路

Also Published As

Publication number Publication date
IL79136A (en) 1991-07-18
ES8801201A1 (es) 1988-01-01
EP0207681A3 (en) 1988-06-01
ES556351A0 (es) 1988-01-01
NZ216550A (en) 1990-02-26
FI82446B (fi) 1990-11-30
AU587258B2 (en) 1989-08-10
JPS62461A (ja) 1987-01-06
PT82815B (pt) 1988-04-21
PT82813A (en) 1986-07-01
NO862486L (no) 1986-12-22
DE3684368D1 (de) 1992-04-23
NO862486D0 (no) 1986-06-20
AU5891986A (en) 1986-12-24
US4824861A (en) 1989-04-25
PT82815A (en) 1986-07-01
HU196225B (en) 1988-10-28
NO168428B (no) 1991-11-11
GR861577B (en) 1986-10-21
IT1190378B (it) 1988-02-16
FI862420A (fi) 1986-12-22
HUT43815A (en) 1987-12-28
NO168428C (no) 1992-02-19
DK290286A (da) 1986-12-22
IL79136A0 (en) 1986-09-30
EP0207681B1 (en) 1992-03-18
FI82446C (fi) 1991-03-11
ES8800164A1 (es) 1987-11-01
PH22851A (en) 1989-01-19
CA1284248C (en) 1991-05-14
KR870000294A (ko) 1987-02-17
ES556353A0 (es) 1987-11-01
EP0207681A2 (en) 1987-01-07
PT82813B (pt) 1988-04-21
FI862420A0 (fi) 1986-06-06
ATE73821T1 (de) 1992-04-15
DK290286D0 (da) 1986-06-20
IT8521234A0 (it) 1985-06-21
KR930006766B1 (ko) 1993-07-23

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