ZA861708B - Cyclopenta(d)pyrimidine derivatives,their preparation and use - Google Patents

Cyclopenta(d)pyrimidine derivatives,their preparation and use

Info

Publication number
ZA861708B
ZA861708B ZA861708A ZA861708A ZA861708B ZA 861708 B ZA861708 B ZA 861708B ZA 861708 A ZA861708 A ZA 861708A ZA 861708 A ZA861708 A ZA 861708A ZA 861708 B ZA861708 B ZA 861708B
Authority
ZA
South Africa
Prior art keywords
sup
cyclopenta
preparation
pyrimidine derivatives
hydrogen
Prior art date
Application number
ZA861708A
Other languages
English (en)
Inventor
Nobuyoshi Iwata
Isao Nakayama
Kanichi Nakamura
Tomio Kimura
Takashi Kobayashi
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of ZA861708B publication Critical patent/ZA861708B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Dental Preparations (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Soil Working Implements (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Eyeglasses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA861708A 1985-03-07 1986-03-07 Cyclopenta(d)pyrimidine derivatives,their preparation and use ZA861708B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4362685 1985-03-07

Publications (1)

Publication Number Publication Date
ZA861708B true ZA861708B (en) 1986-11-26

Family

ID=12669058

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA861708A ZA861708B (en) 1985-03-07 1986-03-07 Cyclopenta(d)pyrimidine derivatives,their preparation and use

Country Status (15)

Country Link
US (1) US4749704A (no)
EP (1) EP0194161B1 (no)
JP (1) JPS6270A (no)
KR (1) KR890003839B1 (no)
AT (1) ATE106077T1 (no)
AU (1) AU580391B2 (no)
CA (1) CA1273632A (no)
DE (1) DE3689848T2 (no)
DK (1) DK165109C (no)
ES (3) ES8704905A1 (no)
FI (1) FI88717C (no)
HK (1) HK1005450A1 (no)
IE (1) IE64504B1 (no)
NO (1) NO168767C (no)
ZA (1) ZA861708B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
US5877178A (en) * 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5234936A (en) * 1991-10-24 1993-08-10 American Home Products Corporation Pyrimidocycloalkanes as a ii antagonists
EP1656354B1 (en) * 2003-08-12 2007-09-26 F.Hoffmann-La Roche Ag Tetrahydroquinazoline derivatives as cfr antagonists
JPWO2007049342A1 (ja) 2005-10-26 2009-04-30 三菱電機株式会社 エレベーター群管理制御装置
JP5231411B2 (ja) 2006-07-06 2013-07-10 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのジヒドロチエノピリミジン
EP2049500B1 (en) 2006-07-06 2011-09-07 Array Biopharma, Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
WO2008006025A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2008021456A2 (en) * 2006-08-16 2008-02-21 Cytovia, Inc. N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
SI2173723T1 (sl) 2007-07-05 2011-12-30 Array Biopharma Inc Pirimidil ciklopentani kot inhibitorji AKT-protein-kinaze
RU2486181C2 (ru) 2007-07-05 2013-06-27 Эррэй Биофарма Инк. Пиримидилциклопентаны как ингибиторы акт-протеинкиназ
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
KR101624753B1 (ko) 2008-01-09 2016-05-26 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 저해물질로서의 수산화된 피리미딜 시클로펜탄
ES2401685T3 (es) 2008-01-09 2013-04-23 Array Biopharma, Inc. Pirimidil ciclopentano hidroxilado como inhibidor de la proteína quinasa AKT
WO2010047201A1 (ja) 2008-10-20 2010-04-29 三菱電機株式会社 エレベーター群管理装置
ES2620644T3 (es) 2011-04-01 2017-06-29 Genentech, Inc. Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso
MX2013011333A (es) 2011-04-01 2014-04-16 Genentech Inc Combinaciones de compuestos inhibidores de akt y mek, y metodos de uso.
GB201121127D0 (en) 2011-12-08 2012-01-18 Dow Corning Treatment of filler with silane
CN111303053B (zh) * 2020-03-16 2023-01-17 中国海洋大学 环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470182A (en) * 1967-02-09 1969-09-30 Sandoz Ag 4-amino-substituted quinazolines
US3980650A (en) * 1972-05-05 1976-09-14 N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia 4-Amino-pyrimidine derivatives
US3915976A (en) * 1972-09-01 1975-10-28 Sandoz Ag Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines
PH20344A (en) * 1981-01-29 1986-12-04 Sankyo Co Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them
JPS57203072A (en) * 1981-06-05 1982-12-13 Sankyo Co Ltd 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

Also Published As

Publication number Publication date
IE860597L (en) 1986-09-07
IE64504B1 (en) 1995-08-09
ES552796A0 (es) 1987-04-16
ATE106077T1 (de) 1994-06-15
AU5448186A (en) 1986-09-11
HK1005450A1 (en) 1999-01-08
US4749704A (en) 1988-06-07
DE3689848T2 (de) 1995-01-12
ES8704905A1 (es) 1987-04-16
AU580391B2 (en) 1989-01-12
DK165109B (da) 1992-10-12
ES557199A0 (es) 1988-01-01
DE3689848D1 (de) 1994-06-30
FI860969A0 (fi) 1986-03-07
FI88717B (fi) 1993-03-15
DK106586D0 (da) 1986-03-07
CA1273632A (en) 1990-09-04
ES8801221A1 (es) 1988-01-01
KR890003839B1 (ko) 1989-10-05
JPS6270A (ja) 1987-01-06
ES8801222A1 (es) 1988-01-01
NO168767C (no) 1992-04-01
DK165109C (da) 1993-03-01
FI860969A (fi) 1986-09-08
NO168767B (no) 1991-12-23
DK106586A (da) 1986-09-08
KR860007221A (ko) 1986-10-08
EP0194161B1 (en) 1994-05-25
EP0194161A3 (en) 1987-09-02
FI88717C (fi) 1993-06-28
NO860852L (no) 1986-09-08
ES557198A0 (es) 1988-01-01
EP0194161A2 (en) 1986-09-10

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