ZA859573B - Homodisacharide hypoglycemic agents - Google Patents

Homodisacharide hypoglycemic agents

Info

Publication number
ZA859573B
ZA859573B ZA859573A ZA859573A ZA859573B ZA 859573 B ZA859573 B ZA 859573B ZA 859573 A ZA859573 A ZA 859573A ZA 859573 A ZA859573 A ZA 859573A ZA 859573 B ZA859573 B ZA 859573B
Authority
ZA
South Africa
Prior art keywords
homodisacharide
hypoglycemic agents
homonojirimycin
protected
inhibitors
Prior art date
Application number
ZA859573A
Other languages
English (en)
Inventor
Paul S Liu
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA859573B publication Critical patent/ZA859573B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Luminescent Compositions (AREA)
ZA859573A 1984-12-18 1985-12-13 Homodisacharide hypoglycemic agents ZA859573B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/683,127 US4634765A (en) 1984-12-18 1984-12-18 Homodisaccharide hypoglycemic agents

Publications (1)

Publication Number Publication Date
ZA859573B true ZA859573B (en) 1986-08-27

Family

ID=24742682

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA859573A ZA859573B (en) 1984-12-18 1985-12-13 Homodisacharide hypoglycemic agents

Country Status (20)

Country Link
US (1) US4634765A (cg-RX-API-DMAC7.html)
EP (1) EP0186103B1 (cg-RX-API-DMAC7.html)
JP (1) JPS61158994A (cg-RX-API-DMAC7.html)
KR (1) KR900005607B1 (cg-RX-API-DMAC7.html)
CN (1) CN1016784B (cg-RX-API-DMAC7.html)
AT (1) ATE62249T1 (cg-RX-API-DMAC7.html)
AU (1) AU574246B2 (cg-RX-API-DMAC7.html)
CA (1) CA1240989A (cg-RX-API-DMAC7.html)
DE (1) DE3582420D1 (cg-RX-API-DMAC7.html)
DK (1) DK587085A (cg-RX-API-DMAC7.html)
ES (1) ES8706164A1 (cg-RX-API-DMAC7.html)
FI (1) FI80707C (cg-RX-API-DMAC7.html)
GR (1) GR853032B (cg-RX-API-DMAC7.html)
HU (1) HU194263B (cg-RX-API-DMAC7.html)
IE (1) IE58186B1 (cg-RX-API-DMAC7.html)
NO (1) NO162387B (cg-RX-API-DMAC7.html)
NZ (1) NZ214570A (cg-RX-API-DMAC7.html)
PH (1) PH23660A (cg-RX-API-DMAC7.html)
PT (1) PT81689B (cg-RX-API-DMAC7.html)
ZA (1) ZA859573B (cg-RX-API-DMAC7.html)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2181729B (en) * 1985-10-12 1990-04-04 Nippon Shinyaku Co Ltd Glucosylmoranoline derivatives and production thereof
JPS62242692A (ja) * 1986-04-15 1987-10-23 Nippon Shinyaku Co Ltd モラノリン誘導体の製造法
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
EP0345104B1 (en) * 1988-06-02 1995-11-02 Merrell Dow Pharmaceuticals Inc. Novel Alpha-glucosidase inhibitors
US4880917A (en) * 1988-07-01 1989-11-14 Merrell Dow Pharmaceuticals Inc. Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) * 1988-09-16 1990-03-13 Merrell Dow Pharmaceuticals Inc. Synthesis of intermediate useful in the preparation of nojirimycin and related compounds
US5227479A (en) * 1989-12-20 1993-07-13 Merrell Dow Pharmaceuticals Inc. Process for the preparation of nojirimycin and related compounds
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
ES2363230T3 (es) * 1997-04-15 2011-07-27 Csir Métodos no terapéuticos para suprimir el apetito.
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
US6462197B2 (en) 2000-03-31 2002-10-08 Board Of Trustees Of Michigan State University Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005308575A1 (en) * 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
PL2027137T3 (pl) 2005-06-08 2015-08-31 Amicus Therapeutics Inc Oczyszczanie imino- i aminocukrów
JP2008543784A (ja) * 2005-06-08 2008-12-04 アミカス セラピューティックス インコーポレイテッド 結晶性糖組成物および作製方法
WO2006133448A1 (en) * 2005-06-08 2006-12-14 Amicus Therapeutics, Inc. Stabilization of triflated compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
ES2371393T3 (es) 2007-03-12 2011-12-30 Zadec Aps Extracto antidiabético de rooibos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
WO2011145022A1 (en) 2010-05-21 2011-11-24 Pfizer Inc. 2-phenyl benzoylamides
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN102462726B (zh) * 2010-11-04 2016-03-09 中国医学科学院药物研究所 白树总生物碱及多羟基生物碱化合物的提取、分离及用途
US20130345392A1 (en) 2011-03-04 2013-12-26 Pfizer Inc Edn3-like peptides and uses thereof
EP2712362A4 (en) * 2011-05-13 2014-12-24 Glycom As MANUFACTURE OF LACTO-N-TETRAOSE
MY188344A (en) 2012-03-09 2021-12-01 Biotropics Malaysia Berhad Extract formulations of rhodamnia cinerea and uses thereof
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
CA2959208C (en) 2014-08-29 2023-09-19 Tes Pharma S.R.L. Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN104530150A (zh) * 2015-01-14 2015-04-22 佛山市赛维斯医药科技有限公司 含胺基苯和双葡萄糖苷结构化合物、其制备方法和用途
AU2017342083A1 (en) 2016-10-14 2019-04-11 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
IT201700078102A1 (it) 2017-07-11 2019-01-11 Dipharma Francis Srl Sintesi di un azazucchero e suoi intermedi
CN108828121B (zh) * 2018-06-14 2020-06-05 华润三九医药股份有限公司 一种白树药材中α-高野尻霉素的含量检测方法
JP7638868B2 (ja) 2018-11-20 2025-03-04 ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ α－アミノ－β－カルボキシムコン酸セミアルデヒドデカルボキシラーゼ阻害剤
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2848117A1 (de) * 1978-11-06 1980-05-14 Bayer Ag Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
FI854944A0 (fi) 1985-12-13
IE58186B1 (en) 1993-07-28
NZ214570A (en) 1988-03-30
HU194263B (en) 1988-01-28
KR860004921A (ko) 1986-07-16
NO855087L (no) 1986-06-19
PT81689B (pt) 1987-11-30
HUT40137A (en) 1986-11-28
PH23660A (en) 1989-09-27
JPS61158994A (ja) 1986-07-18
AU574246B2 (en) 1988-06-30
DK587085D0 (da) 1985-12-17
DK587085A (da) 1986-06-19
US4634765A (en) 1987-01-06
CA1240989A (en) 1988-08-23
EP0186103A3 (en) 1988-02-03
ES8706164A1 (es) 1987-06-01
JPH0565519B2 (cg-RX-API-DMAC7.html) 1993-09-17
NO162387B (no) 1989-09-11
FI80707C (fi) 1990-07-10
CN1016784B (zh) 1992-05-27
KR900005607B1 (ko) 1990-07-31
GR853032B (cg-RX-API-DMAC7.html) 1986-04-18
AU5081085A (en) 1986-06-26
EP0186103B1 (en) 1991-04-03
FI854944L (fi) 1986-06-19
ES550060A0 (es) 1987-06-01
FI80707B (fi) 1990-03-30
EP0186103A2 (en) 1986-07-02
IE853179L (en) 1986-06-18
ATE62249T1 (de) 1991-04-15
CN85109548A (zh) 1986-07-09
PT81689A (en) 1986-01-01
DE3582420D1 (de) 1991-05-08

Similar Documents

Publication Publication Date Title
EP0186103A3 (en) Homodisaccharide hypoglycemic agents
AU550080B2 (en) Elastomeric active agent delivery system
AU575668B2 (en) N - acylpyrrolidine compound
AU573300B2 (en) Sodium hypophosphite modified acryic acid copolymers
AU4825285A (en) Surfactant containing anhydrous drug systems
GB8704038D0 (en) Protected enzyme systems
AU536200B2 (en) Compound having anthelmintic and acaricidal activities
AU5125685A (en) Inhibition of decomposition of hydrogen peroxide systems
AU6675381A (en) Protection of substrates from microorganisms
DE3563044D1 (en) Optically active di(3-chlor-2-oxypropyl-trimethyl-ammonium) tartrate
AU563995B2 (en) Hypotriglyceridemically active polysaccharides
AU3994085A (en) Compositions contenant des lipides actifs
EP0114389A3 (en) Substituted arylglyoxal derivatives
ES8701149A1 (es) Procedimiento para la preparacion de alfa-aminoacidos alfa- alenicos
SU1166473A1 (ru) ДИТИОАЦЕТИЛГИДРАЗОН α -КАМФОРХИНОНА, ПРОЯВЛЯЮЩИЙ ПРОТИВОГИПОКСИЧЕСКУЮ АКТИВНОСТЬ
PL239327A1 (en) Method of isolation of polyfungine from the culture of highefficient mutant of streptomyces noursei var. polifungini strain
AU2557084A (en) Production of alpha-amylase inhibitor-tendamistat from streptomyces
GB8417649D0 (en) Active vibration cancelling mount
MTP997B (en) Protected enzyme systems
IE870432L (en) Protected enzyme systems
CA1266642C (en) MONOSACCHARIDE COMPOUNDS WITH IMMUNOSTIMULATING ACTION
IE861883L (en) Enzymes which catalyze the degradation of lignin
AU8315687A (en) Propagation of seedlings
IT8320426A0 (it) Composizione di policarbonato autoestinguente.
IT8320903A0 (it) Composizione di policarbonato autoestinguente.