ZA859382B - New pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents
New pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing themInfo
- Publication number
- ZA859382B ZA859382B ZA859382A ZA859382A ZA859382B ZA 859382 B ZA859382 B ZA 859382B ZA 859382 A ZA859382 A ZA 859382A ZA 859382 A ZA859382 A ZA 859382A ZA 859382 B ZA859382 B ZA 859382B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparation
- processes
- pharmaceutical compositions
- compositions containing
- pyrrolobenzimidazoles
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- BKOVMXWXILSWCU-UHFFFAOYSA-N pyrrolo[3,2-e]benzimidazole Chemical class C1=CC2=NC=CC2=C2N=CN=C21 BKOVMXWXILSWCU-UHFFFAOYSA-N 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843445669 DE3445669A1 (de) | 1984-12-14 | 1984-12-14 | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA859382B true ZA859382B (en) | 1986-08-27 |
Family
ID=6252801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA859382A ZA859382B (en) | 1984-12-14 | 1985-12-09 | New pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them |
Country Status (16)
Country | Link |
---|---|
US (2) | US4710510A (fr) |
EP (1) | EP0186010B1 (fr) |
JP (1) | JPS61158984A (fr) |
AT (1) | ATE49970T1 (fr) |
AU (1) | AU580822B2 (fr) |
CA (1) | CA1262908A (fr) |
CS (1) | CS276403B6 (fr) |
DD (1) | DD242045A5 (fr) |
DE (2) | DE3445669A1 (fr) |
DK (1) | DK579185A (fr) |
ES (1) | ES8702409A1 (fr) |
FI (1) | FI79318C (fr) |
GR (1) | GR852979B (fr) |
HU (1) | HU194241B (fr) |
SU (1) | SU1440348A3 (fr) |
ZA (1) | ZA859382B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3501497A1 (de) * | 1985-01-18 | 1986-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
DE3531678A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE3626664A1 (de) * | 1986-08-07 | 1988-02-11 | Boehringer Mannheim Gmbh | Tricyclische benzotriazole, verfahren zu ihrer herstellung sowie arzneimittel |
DE3639466A1 (de) * | 1986-11-18 | 1988-05-19 | Thomae Gmbh Dr K | Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE3642315A1 (de) * | 1986-12-11 | 1988-06-23 | Boehringer Mannheim Gmbh | Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel |
DE3701277A1 (de) * | 1987-01-17 | 1988-07-28 | Boehringer Mannheim Gmbh | Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel |
DE3740985A1 (de) * | 1987-12-03 | 1989-06-15 | Boehringer Mannheim Gmbh | Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation |
US4963677A (en) * | 1987-12-30 | 1990-10-16 | Orion Corporation Ltd. | Heterocyclic lactam compounds |
EP0322746B1 (fr) * | 1987-12-30 | 1996-05-29 | Orion Corporation Limited | Composés hétérocycliques |
DE3803775A1 (de) * | 1988-02-09 | 1989-08-17 | Boehringer Mannheim Gmbh | Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
DE4027592A1 (de) * | 1990-08-31 | 1992-03-05 | Beiersdorf Ag | Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
WO2002070478A1 (fr) * | 2001-03-06 | 2002-09-12 | Astrazeneca Ab | Dérivés indolone capable de dégrader des vaisseaux |
US6951848B2 (en) * | 2001-03-12 | 2005-10-04 | Millennium Pharmaceuticals, Inc., | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
EP1737414A2 (fr) * | 2004-01-23 | 2007-01-03 | Amgen Inc. | Ligands du récepteur vanilloide et leur utilisation pour le traitement de douleurs inflammatoires et neuropatiques |
KR101706877B1 (ko) | 2012-09-13 | 2017-02-15 | 에프. 호프만-라 로슈 아게 | Cns 장애의 치료를 위한 2-옥소-2,3-다이하이드로-인돌 |
BR112017002053A2 (pt) | 2014-08-01 | 2018-01-30 | Nuevolution A/S | composto de acordo com a fórmula (i), composição farmacêutica, e usos de um composto |
GB201709456D0 (en) | 2017-06-14 | 2017-07-26 | Ucb Biopharma Sprl | Therapeutic agents |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4234571A (en) * | 1979-06-11 | 1980-11-18 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone |
DE3163018D1 (en) * | 1980-02-02 | 1984-05-17 | Beecham Group Plc | Pyrano derivatives, a process for their preparation and antihypertensive compositions containing them |
FR2476644A1 (fr) * | 1980-02-21 | 1981-08-28 | Sarget Lab | Orthoarylydeneaminophenethylamine, leur preparation et leur utilisation therapeutique |
DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
SU1068439A1 (ru) * | 1982-10-28 | 1984-01-23 | Новокузнецкий научно-исследовательский химико-фармацевтический институт | Производные имидазо(4,5- @ ) индолов |
US4579865A (en) * | 1983-02-14 | 1986-04-01 | Usv Pharmaceutical Corp. | Benzofuranyl carbamates |
US4548943A (en) * | 1984-05-11 | 1985-10-22 | E. I. Du Pont De Nemours And Company | Antiinflammatory, analgesic, or anti-primary dysmenorrheal arylmethylene- and arylmethylindenoimidazoles |
PL144822B1 (en) * | 1984-05-12 | 1988-07-30 | Boehringer Mannheim Gmbh | Method of obtaining novel pyrolobenzimidazoles |
DE3501497A1 (de) * | 1985-01-18 | 1986-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
DE3531678A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1984
- 1984-12-14 DE DE19843445669 patent/DE3445669A1/de not_active Withdrawn
-
1985
- 1985-12-06 EP EP85115547A patent/EP0186010B1/fr not_active Expired - Lifetime
- 1985-12-06 AT AT85115547T patent/ATE49970T1/de not_active IP Right Cessation
- 1985-12-06 DE DE8585115547T patent/DE3575725D1/de not_active Expired - Lifetime
- 1985-12-09 AU AU51006/85A patent/AU580822B2/en not_active Ceased
- 1985-12-09 ZA ZA859382A patent/ZA859382B/xx unknown
- 1985-12-10 US US06/807,260 patent/US4710510A/en not_active Expired - Fee Related
- 1985-12-10 ES ES549776A patent/ES8702409A1/es not_active Expired
- 1985-12-12 GR GR852979A patent/GR852979B/el unknown
- 1985-12-12 CS CS859195A patent/CS276403B6/cs unknown
- 1985-12-12 FI FI854926A patent/FI79318C/fi not_active IP Right Cessation
- 1985-12-12 DD DD85284206A patent/DD242045A5/de not_active IP Right Cessation
- 1985-12-13 HU HU854775A patent/HU194241B/hu not_active IP Right Cessation
- 1985-12-13 SU SU853995762A patent/SU1440348A3/ru active
- 1985-12-13 DK DK579185A patent/DK579185A/da not_active Application Discontinuation
- 1985-12-13 JP JP60279391A patent/JPS61158984A/ja active Granted
- 1985-12-13 CA CA000497668A patent/CA1262908A/fr not_active Expired
-
1987
- 1987-10-01 US US07/103,895 patent/US4810801A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HU194241B (en) | 1988-01-28 |
DD242045A5 (de) | 1987-01-14 |
DE3445669A1 (de) | 1986-06-19 |
JPS61158984A (ja) | 1986-07-18 |
DK579185D0 (da) | 1985-12-13 |
FI79318C (fi) | 1989-12-11 |
ES549776A0 (es) | 1987-01-16 |
AU580822B2 (en) | 1989-02-02 |
US4710510A (en) | 1987-12-01 |
CA1262908A (fr) | 1989-11-14 |
ATE49970T1 (de) | 1990-02-15 |
CS919585A3 (en) | 1992-01-15 |
EP0186010B1 (fr) | 1990-01-31 |
EP0186010A1 (fr) | 1986-07-02 |
SU1440348A3 (ru) | 1988-11-23 |
AU5100685A (en) | 1986-06-19 |
ES8702409A1 (es) | 1987-01-16 |
GR852979B (fr) | 1986-04-08 |
DK579185A (da) | 1986-06-15 |
FI854926A (fi) | 1986-06-15 |
DE3575725D1 (de) | 1990-03-08 |
FI854926A0 (fi) | 1985-12-12 |
JPH0471914B2 (fr) | 1992-11-16 |
HUT40436A (en) | 1986-12-28 |
FI79318B (fi) | 1989-08-31 |
US4810801A (en) | 1989-03-07 |
CS276403B6 (en) | 1992-05-13 |
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