ZA85656B - Asymmetrical alkyl diphenylalkylaminoalkyl esters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid - Google Patents
Asymmetrical alkyl diphenylalkylaminoalkyl esters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acidInfo
- Publication number
- ZA85656B ZA85656B ZA85656A ZA85656A ZA85656B ZA 85656 B ZA85656 B ZA 85656B ZA 85656 A ZA85656 A ZA 85656A ZA 85656 A ZA85656 A ZA 85656A ZA 85656 B ZA85656 B ZA 85656B
- Authority
- ZA
- South Africa
- Prior art keywords
- diphenylalkylaminoalkyl
- dihydro
- pyridine
- esters
- dimethyl
- Prior art date
Links
- FEWLBZQGGXQGSH-UHFFFAOYSA-N 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid Chemical compound CC1=C(C(O)=O)CC(C(O)=O)=C(C)N1 FEWLBZQGGXQGSH-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848403866A GB8403866D0 (en) | 1984-02-14 | 1984-02-14 | Diphenylalkylaminoalkyl esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA85656B true ZA85656B (en) | 1985-08-28 |
Family
ID=10556581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA85656A ZA85656B (en) | 1984-02-14 | 1985-01-28 | Asymmetrical alkyl diphenylalkylaminoalkyl esters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US4705797A (OSRAM) |
| EP (1) | EP0153016B1 (OSRAM) |
| JP (1) | JPS60199874A (OSRAM) |
| KR (1) | KR910005231B1 (OSRAM) |
| AR (1) | AR240804A1 (OSRAM) |
| AT (1) | ATE52772T1 (OSRAM) |
| AU (1) | AU570534B2 (OSRAM) |
| BR (1) | BR1101167A (OSRAM) |
| CA (1) | CA1277666C (OSRAM) |
| DE (2) | DE10199007I2 (OSRAM) |
| DK (1) | DK160985C (OSRAM) |
| DZ (1) | DZ748A1 (OSRAM) |
| EG (1) | EG17772A (OSRAM) |
| ES (1) | ES540385A0 (OSRAM) |
| FI (1) | FI83954C (OSRAM) |
| GB (1) | GB8403866D0 (OSRAM) |
| GR (1) | GR850363B (OSRAM) |
| HU (1) | HU194171B (OSRAM) |
| IE (1) | IE57715B1 (OSRAM) |
| IL (1) | IL74238A (OSRAM) |
| LU (1) | LU90069I2 (OSRAM) |
| MX (1) | MX156874A (OSRAM) |
| NL (1) | NL970025I2 (OSRAM) |
| NO (2) | NO166123C (OSRAM) |
| NZ (1) | NZ210866A (OSRAM) |
| PH (1) | PH20725A (OSRAM) |
| PT (1) | PT79963B (OSRAM) |
| SG (1) | SG48590G (OSRAM) |
| ZA (1) | ZA85656B (OSRAM) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU561213B2 (en) * | 1983-06-02 | 1987-04-30 | Teijin Limited | 1, 4-dihydropyridine derivative |
| US4994476A (en) * | 1984-10-31 | 1991-02-19 | Bristol-Myers Company | Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties |
| DE3677319D1 (de) * | 1985-10-22 | 1991-03-07 | Sanwa Kagaku Kenkyusho Co | Pharmazeutische 1,4-dihydropyridinderivate, ihre salze und herstellung. |
| DE3633496A1 (de) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln |
| JPH02149563A (ja) * | 1988-11-30 | 1990-06-08 | Nisshin Flour Milling Co Ltd | ２−ハロエトキシカルボニル基を含有する１，４−ジヒドロピリジン誘導体の製造法 |
| IT1275532B (it) * | 1995-07-14 | 1997-08-07 | Recordati Chem Pharm | Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa |
| IT1279529B1 (it) * | 1995-05-12 | 1997-12-16 | Recordati Chem Pharm | Procedimento di preparazione ed uso degli enantiomeri (s) di derivati 1,4-diidropiridinici per il trattamento dell'insufficienza cardiaca |
| IT1274480B (it) * | 1995-05-12 | 1997-07-17 | Recordati Chem Pharm | Procedimento migliorato per la preparazione della lercanidipina cloridrato |
| US5696139A (en) * | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
| US5912351A (en) * | 1995-05-12 | 1999-06-15 | Recordati, S.A. Chemical And Pharmaceutical Company | Anhydrous 1,4-Dihydropyridines and salts thereof |
| US5851636A (en) * | 1995-12-29 | 1998-12-22 | Lantec Products, Inc. | Ceramic packing with channels for thermal and catalytic beds |
| RU2200315C2 (ru) * | 2001-05-25 | 2003-03-10 | Чалкин Станислав Филиппович | Устройство для анализа жидких сред люминесцентным методом |
| ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
| US6852737B2 (en) * | 2001-08-06 | 2005-02-08 | Recordati Ireland Limited | Crude and crystalline forms of lercanidipine hydrochloride |
| ITMI20011727A1 (it) * | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi |
| RS20050106A (en) | 2002-08-19 | 2007-11-15 | Pfizer Products Inc., | Combination therapy for hyperproliferative diseases |
| US20050101640A1 (en) * | 2002-10-16 | 2005-05-12 | Recordati Ireland Limited | Lisinopril/lercanidipine combination therapy |
| US20040147566A1 (en) * | 2002-10-16 | 2004-07-29 | Amedeo Leonardi | Lisinopril/lercanidipine combination therapy |
| AU2004242777B2 (en) | 2003-05-30 | 2011-05-12 | Ranbaxy Laboratories Limited | Substituted pyrrole derivatives and their use as HMG-Co inhibitors |
| WO2005107374A2 (en) * | 2004-05-07 | 2005-11-17 | Sun Pharmaceutical Industries Limited | A process for the preparation of 1,4-dihydropyridine-3,5-dicarboxylic acid derivative |
| WO2006014930A2 (en) * | 2004-07-26 | 2006-02-09 | Cotherix, Inc. | Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation |
| TW200613275A (en) * | 2004-08-24 | 2006-05-01 | Recordati Ireland Ltd | Lercanidipine salts |
| US20060134212A1 (en) * | 2004-09-02 | 2006-06-22 | Forest Laboratories, Inc. | Lercanidipine immediate release compositions |
| US20060165788A1 (en) * | 2004-09-09 | 2006-07-27 | Wattanaporn Abramowitz | Lercanidipine pH dependent pulsatile release compositions |
| US20060165789A1 (en) * | 2004-09-09 | 2006-07-27 | Forest Laboratories, Inc. | Lercanidipine modified release compositions |
| KR100616276B1 (ko) * | 2004-09-21 | 2006-08-28 | 일동제약주식회사 | 2,엔-디메틸-엔-(3,3-디페닐프로필)-1-아미노-2-프로판올의제조방법 |
| TW200616681A (en) * | 2004-10-05 | 2006-06-01 | Recordati Ireland Ltd | Lercanidipine capsules |
| KR100651212B1 (ko) * | 2004-10-27 | 2006-12-01 | 제일약품주식회사 | 무정형 레르카니디핀의 제조방법 |
| IL165525A0 (en) * | 2004-12-02 | 2006-01-15 | Motivan Ltd | Intermediates and a process for the manufacturing for antihypertensive dihydropyridine derivative suitable for pharmaceutical compositions |
| AR053023A1 (es) * | 2005-02-25 | 2007-04-18 | Recordati Ireland Ltd | Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienen |
| AR052918A1 (es) * | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
| KR100638171B1 (ko) * | 2005-03-25 | 2006-10-26 | 건일제약 주식회사 | 2,ｎ-디메틸-ｎ-(3,3-디페닐프로필)-1-아미노-2-프로판올의제조방법 |
| PT1891009E (pt) * | 2005-06-15 | 2010-01-19 | Hetero Drugs Ltd | Processo inédito para a preparação de lercanidipina |
| RU2425033C2 (ru) * | 2005-09-16 | 2011-07-27 | Гленмарк Фармасьютикалз Лимитед | Полиморфная форма гидрохлорида лерканидипина и способ ее получения |
| EP1963254A2 (en) * | 2005-09-21 | 2008-09-03 | Torrent Pharmaceuticals Ltd | Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| ATE551059T1 (de) | 2005-10-26 | 2012-04-15 | Asahi Kasei Pharma Corp | Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie |
| EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| KR101329112B1 (ko) | 2005-11-08 | 2013-11-14 | 랜박시 래보러터리스 리미티드 | (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법 |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| WO2007120135A1 (en) * | 2006-04-17 | 2007-10-25 | Forest Laboratories, Inc. | Lercanidipine immediate release composition |
| EP1860102B1 (en) * | 2006-05-24 | 2008-11-26 | CF Pharma Ltd. | Process for Producing Lercanidipine |
| ES2443523T3 (es) * | 2006-08-04 | 2014-02-19 | Recordati Ireland Limited | Procedimiento para la preparación de hidrocloruro de lercanidipina amorfo |
| US20080175872A1 (en) * | 2006-09-28 | 2008-07-24 | Osmotica Corp. | Controlled Release Dosage Form Containing Lercanidipine and a Performance-enhancing Acid |
| EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| WO2008082041A1 (en) * | 2006-12-29 | 2008-07-10 | Dongwoo Syntech Co., Ltd | Process for preparing lercanidipine hydrochloride |
| KR100848935B1 (ko) | 2007-05-16 | 2008-07-29 | 주식회사 대희화학 | 생체 촉매 효소를 이용한 광학 선택적 가수분해방법 |
| WO2011161223A2 (en) | 2010-06-23 | 2011-12-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts |
| US8883844B2 (en) | 2010-09-24 | 2014-11-11 | Nitrogenix Inc. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
| EP2444394A1 (en) | 2010-10-21 | 2012-04-25 | Alembic Pharmaceuticals Limited | Process for the preparation of amorphous form of lercanidipine HCI |
| EA023996B1 (ru) | 2010-12-24 | 2016-08-31 | КРКА, д.д., НОВО МЕСТО | Гомогенные фармацевтические пероральные лекарственные формы, содержащие лерканидипин и эналаприл или их фармацевтически приемлемые соли совместно с органической кислотой |
| WO2012123966A1 (en) | 2011-03-04 | 2012-09-20 | Arch Pharmalabs Limited | Process for the preparation of 4 -substituted -1, 4-dihydropyridines |
| RU2618628C1 (ru) | 2013-04-17 | 2017-05-05 | Пфайзер Инк. | Производные N-пиперидин-3-илбензамида для лечения сердечно-сосудистых заболеваний |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| CN119119023A (zh) | 2019-01-18 | 2024-12-13 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985758A (en) * | 1973-02-20 | 1976-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives |
| JPS5762257A (en) * | 1980-10-03 | 1982-04-15 | Yoshitomi Pharmaceut Ind Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid ester or its salt |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
| DE3269219D1 (en) * | 1981-11-17 | 1986-03-27 | Fisons Plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
| EP0094159B1 (en) * | 1982-05-10 | 1990-03-14 | Takeda Chemical Industries, Ltd. | Dihydropyridine derivatives, their production and use |
| AU561213B2 (en) * | 1983-06-02 | 1987-04-30 | Teijin Limited | 1, 4-dihydropyridine derivative |
| NO854021L (no) * | 1984-10-26 | 1986-04-28 | Bayer Ag | 1,4-dihydropyridin-hydroksyaminer og fremgangsmaate til fremstilling derav. |
| GB8503424D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Heterocyclic derivatives |
-
1984
- 1984-02-14 GB GB848403866A patent/GB8403866D0/en active Pending
-
1985
- 1985-01-17 NZ NZ210866A patent/NZ210866A/xx unknown
- 1985-01-21 DE DE2001199007 patent/DE10199007I2/de active Active
- 1985-01-21 AT AT85300384T patent/ATE52772T1/de active
- 1985-01-21 DE DE8585300384T patent/DE3577703D1/de not_active Expired - Lifetime
- 1985-01-21 EP EP85300384A patent/EP0153016B1/en not_active Expired - Lifetime
- 1985-01-28 ZA ZA85656A patent/ZA85656B/xx unknown
- 1985-02-04 IL IL74238A patent/IL74238A/xx not_active IP Right Cessation
- 1985-02-06 IE IE280/85A patent/IE57715B1/en not_active IP Right Cessation
- 1985-02-08 FI FI850535A patent/FI83954C/fi not_active IP Right Cessation
- 1985-02-11 CA CA000474009A patent/CA1277666C/en not_active Expired - Lifetime
- 1985-02-11 GR GR850363A patent/GR850363B/el not_active IP Right Cessation
- 1985-02-11 EG EG83/85A patent/EG17772A/xx active
- 1985-02-11 AR AR299475A patent/AR240804A1/es active
- 1985-02-12 DK DK063085A patent/DK160985C/da not_active IP Right Cessation
- 1985-02-12 MX MX204305A patent/MX156874A/es unknown
- 1985-02-12 NO NO850521A patent/NO166123C/no unknown
- 1985-02-13 PT PT79963A patent/PT79963B/pt unknown
- 1985-02-13 ES ES540385A patent/ES540385A0/es active Granted
- 1985-02-13 AU AU38689/85A patent/AU570534B2/en not_active Expired
- 1985-02-13 DZ DZ850035A patent/DZ748A1/fr active
- 1985-02-13 KR KR1019850000888A patent/KR910005231B1/ko not_active Expired
- 1985-02-14 US US06/701,672 patent/US4705797A/en not_active Expired - Lifetime
- 1985-02-14 HU HU85554A patent/HU194171B/hu unknown
- 1985-02-14 JP JP60027527A patent/JPS60199874A/ja active Granted
- 1985-02-14 PH PH31860A patent/PH20725A/en unknown
-
1987
- 1987-08-19 US US07/086,739 patent/US4772621A/en not_active Expired - Lifetime
-
1988
- 1988-06-28 US US07/212,472 patent/US4968832A/en not_active Expired - Lifetime
-
1990
- 1990-07-02 SG SG485/90A patent/SG48590G/en unknown
-
1997
- 1997-05-14 BR BR1101167-0A patent/BR1101167A/pt active IP Right Grant
- 1997-05-28 LU LU90069C patent/LU90069I2/fr unknown
- 1997-07-11 NL NL970025C patent/NL970025I2/nl unknown
-
2000
- 2000-10-17 NO NO2000011C patent/NO2000011I1/no unknown
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