ZA853324B - N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents - Google Patents

N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents

Info

Publication number
ZA853324B
ZA853324B ZA853324A ZA853324A ZA853324B ZA 853324 B ZA853324 B ZA 853324B ZA 853324 A ZA853324 A ZA 853324A ZA 853324 A ZA853324 A ZA 853324A ZA 853324 B ZA853324 B ZA 853324B
Authority
ZA
South Africa
Prior art keywords
oxindole
carboxamides
disubstituted
analgesic
antiinflammatory agents
Prior art date
Application number
ZA853324A
Other languages
English (en)
Inventor
Saul Bernard Kadin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA853324B publication Critical patent/ZA853324B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
ZA853324A 1984-05-04 1985-05-03 N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents ZA853324B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60735684A 1984-05-04 1984-05-04

Publications (1)

Publication Number Publication Date
ZA853324B true ZA853324B (en) 1986-12-30

Family

ID=24431933

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA853324A ZA853324B (en) 1984-05-04 1985-05-03 N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents

Country Status (25)

Country Link
JP (1) JPS60243068A (es)
KR (1) KR870000497B1 (es)
AR (1) AR241159A1 (es)
BG (2) BG60208B2 (es)
CS (1) CS252828B2 (es)
DD (1) DD232916A5 (es)
EG (1) EG17193A (es)
ES (2) ES8609248A1 (es)
FI (1) FI80016C (es)
HU (1) HU196057B (es)
IE (1) IE851103L (es)
IN (1) IN161509B (es)
MA (1) MA20424A1 (es)
MW (1) MW1685A1 (es)
MX (1) MX5839A (es)
NO (1) NO163132C (es)
OA (1) OA08098A (es)
PL (2) PL147508B1 (es)
PT (1) PT80375B (es)
RO (2) RO91141B (es)
RU (1) RU2017729C1 (es)
SU (1) SU1468413A3 (es)
YU (1) YU44998B (es)
ZA (1) ZA853324B (es)
ZW (1) ZW7885A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis

Also Published As

Publication number Publication date
AR241159A1 (es) 1991-12-30
DD232916A5 (de) 1986-02-12
CS320285A2 (en) 1987-03-12
EG17193A (en) 1990-08-30
ES8609248A1 (es) 1986-07-16
PL253203A1 (en) 1986-06-17
ES551275A0 (es) 1987-07-16
PL145416B1 (en) 1988-09-30
YU44998B (en) 1991-06-30
MW1685A1 (en) 1986-09-10
MX5839A (es) 1993-11-01
JPH0335315B2 (es) 1991-05-27
RU2017729C1 (ru) 1994-08-15
PL257892A1 (en) 1986-10-07
PL147508B1 (en) 1989-06-30
AR241159A2 (es) 1991-12-30
NO163132B (no) 1990-01-02
OA08098A (fr) 1987-03-31
SU1468413A3 (ru) 1989-03-23
KR850008154A (ko) 1985-12-13
JPS60243068A (ja) 1985-12-03
RO94455A (ro) 1988-06-30
HUT37754A (en) 1986-02-28
FI80016C (fi) 1990-04-10
NO851774L (no) 1985-11-05
PT80375B (pt) 1987-09-30
RO91141A (ro) 1987-06-30
FI851756L (fi) 1985-11-05
KR870000497B1 (ko) 1987-03-12
YU73085A (en) 1988-04-30
ZW7885A1 (en) 1985-07-24
CS252828B2 (en) 1987-10-15
ES8707182A1 (es) 1987-07-16
FI851756A0 (fi) 1985-05-03
HU196057B (en) 1988-09-28
BG60207B2 (en) 1993-12-30
RO91141B (ro) 1987-07-03
FI80016B (fi) 1989-12-29
ES542813A0 (es) 1986-07-16
BG60208B2 (en) 1993-12-30
NO163132C (no) 1990-04-11
PT80375A (en) 1985-05-01
IE851103L (en) 1985-11-04
IN161509B (es) 1987-12-19
RO94455B (ro) 1988-07-01
MA20424A1 (fr) 1985-12-31

Similar Documents

Publication Publication Date Title
DE3570078D1 (en) Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
ZA856387B (en) Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
DE3574379D1 (en) Tetrahydrophtalimides, and their production and use
DE3563627D1 (en) Triazolopyridazines, and their production and use
ZA85888B (en) 1,3-disubstituted oxindoles as analgesic and antiinflammatory agents
ZA865019B (en) 1-substituted oxindole-3-carboxamides as antiinflammatory and analgesic agents
DE3568435D1 (en) 2-acetoacetylglycerol derivatives, their production and use
ZA853379B (en) Substituted 1-oxa-dethiachphalosporins as anti-inflammatory and antidegenerative agents
PH23498A (en) 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof
ZA851521B (en) Phenylthiomethyl-6-hydroxy-2,3-dihydrobenzo-pyran and analogs thereof useful as anti-inflammatory agents
ZA851991B (en) 3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
AU565886B2 (en) Pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides
ZA853324B (en) N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
AU576211B2 (en) N-(naphthyl-alkyl)-hydroxylamines
ZA855469B (en) Tetrahydrophthalimides,and their production and use
PH23393A (en) 1,3-disubstituted oxinoles as analgesic and antiinflammatory agents
AU5178486A (en) 1,3,4-trisubstituted azacyloalkanes and azacycloalkenes
ZM3185A1 (en) N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
DE3569472D1 (en) Pharmaceutical composition, its production and use
CS241184A1 (en) Zpusob vyroby 4 nitro 1,2 dimetylbenzenu
ZA857235B (en) Triazolopyridazines,and their production and use
BG38844A1 (en) Trans- 2- alkylthioureido- 3- hydroxy- 1, 2, 3, 4- tetrahydronaphthalinis, method for their manufacture and use
CS1015384A1 (en) Zarizeni pro aerodynamicke cisteni materialu, zejmena pasu
CS258984A1 (en) Zpusob vyroby vysocepevnych pasu, zejmena pro cyklopasky
CS261484A1 (en) Usporadani pohonu hydraulickeho rizeni, zvlaste pro stavebni stroje