ZA852971B - New process for the synthesis of pyrido-imidazo rifamycins - Google Patents

New process for the synthesis of pyrido-imidazo rifamycins

Info

Publication number
ZA852971B
ZA852971B ZA852971A ZA852971A ZA852971B ZA 852971 B ZA852971 B ZA 852971B ZA 852971 A ZA852971 A ZA 852971A ZA 852971 A ZA852971 A ZA 852971A ZA 852971 B ZA852971 B ZA 852971B
Authority
ZA
South Africa
Prior art keywords
pyrido
synthesis
new process
rifamycins
imidazo
Prior art date
Application number
ZA852971A
Other languages
English (en)
Inventor
Vincenzo Cannata
Gian Franco Tamagnone
Silvano Piani
Egidio Marchi
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of ZA852971B publication Critical patent/ZA852971B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA852971A 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo rifamycins ZA852971B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine

Publications (1)

Publication Number Publication Date
ZA852971B true ZA852971B (en) 1985-12-24

Family

ID=11107845

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA852971A ZA852971B (en) 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo rifamycins

Country Status (18)

Country Link
US (1) US4557866A (member.php)
EP (1) EP0161534B1 (member.php)
JP (1) JPS60252483A (member.php)
AR (1) AR241913A1 (member.php)
AT (1) ATE46512T1 (member.php)
AU (1) AU568934B2 (member.php)
CA (1) CA1215708A (member.php)
DE (1) DE3573120D1 (member.php)
DK (1) DK162647C (member.php)
ES (1) ES543115A0 (member.php)
FI (1) FI81101C (member.php)
GR (1) GR851144B (member.php)
IE (1) IE58392B1 (member.php)
IT (1) IT1199374B (member.php)
NO (1) NO164242C (member.php)
PH (1) PH22007A (member.php)
PT (1) PT80446B (member.php)
ZA (1) ZA852971B (member.php)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
US7906542B2 (en) 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US7902206B2 (en) 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US7923553B2 (en) 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
DK1698630T3 (da) 2005-03-03 2014-12-08 Alfa Wassermann Spa Nye polymorfe former af rifaximin, fremgangsmåde for deres fremstilling og anvendelse deraf i de medicinske præparater
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
US8987292B2 (en) 2006-03-09 2015-03-24 Salix Pharmaceuticals, Ltd. Rifaximin anti-rectal dysfunction preparation
ES2538478T3 (es) 2006-08-02 2015-06-22 Salix Pharmaceuticals, Inc. Métodos para el tratamiento de enteritis por radiación
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
NZ575550A (en) * 2006-09-22 2011-12-22 Cipla Ltd Rifaximin
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US7709634B2 (en) 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
US8486956B2 (en) 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
UA101829C2 (uk) 2008-02-25 2013-05-13 Саликс Фармасьютикалз, Лтд. ФОРМА η РИФАКСИМІНУ І ЇЇ ЗАСТОСУВАННЯ В ТЕРАПЕВТИЧНІЙ ПРАКТИЦІ
ES2727728T3 (es) 2008-02-26 2019-10-18 Salix Pharmaceuticals Ltd Métodos para el tratamiento del síndrome del intestino irritable
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
HRP20140939T1 (hr) 2008-05-07 2014-11-21 Salix Pharmaceuticals, Ltd. Davanje preparata za äśišä†enje crijeva i antibiotika za lijeäśenje bolesti crijeva
CN101585843B (zh) * 2008-05-21 2011-07-06 重庆赛诺生物药业股份有限公司 一种利福昔明的制备工艺
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
US20110035232A1 (en) 2008-10-02 2011-02-10 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
MX364102B (es) 2008-10-02 2019-04-12 Salix Pharmaceuticals Ltd Medicamentos para usarse en el tratamiento de la encefalopatía hepática.
ES2718614T3 (es) 2008-12-10 2019-07-03 Cipla Ltd Complejos de rifaximina
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
EP3964066A1 (en) 2009-06-02 2022-03-09 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
MX2012002895A (es) 2009-09-13 2012-05-22 Salix Pharmaceuticals Ltd Metodos para tratar el sindrome de intestino irritado (ibs).
JP2013511570A (ja) 2009-11-23 2013-04-04 シプラ・リミテッド 局所用泡沫組成物
WO2011080691A1 (en) 2009-12-28 2011-07-07 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
JP5896380B2 (ja) 2010-02-18 2016-03-30 サリックス ファーマスーティカルズ，リミテッド 感染症を治療するための方法
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
WO2011156897A2 (en) * 2010-06-16 2011-12-22 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
PH12013500082B1 (en) 2010-07-12 2019-06-28 Salix Pharmaceuticals Ltd Formulations of rifaximin and uses thereof
WO2012035544A2 (en) 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
EA201391171A1 (ru) 2011-02-11 2014-11-28 Сэликс Фармасьютиклз, Лтд. Формы рифаксимина и их применение
WO2012150561A1 (en) 2011-05-02 2012-11-08 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
WO2012155981A1 (en) 2011-05-19 2012-11-22 Friulchem Spa New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
EP2773205B1 (en) 2011-11-02 2024-05-22 Salix Pharmaceuticals, Inc. Rifaximin for retreating diarrhea-predominant irritable bowel syndrome
US9359374B2 (en) 2012-06-13 2016-06-07 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
EP2971062A2 (en) 2013-03-15 2016-01-20 ALFA WASSERMANN S.p.A. Method for diagnosing vaginal infections
JP2016510809A (ja) 2013-03-15 2016-04-11 アルファ ワッセルマン ソシエタ ペル アチオニＡｌｆａ Ｗａｓｓｅｒｍａｎｎ Ｓ．Ｐ．Ａ． 膣感染症の治療に使用するためのリファキシミン
PT2983647T (pt) 2013-04-12 2020-11-09 Alfasigma Spa Administração de aine e composições, métodos e sistemas relacionados
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ITMI20131307A1 (it) 2013-08-02 2015-02-02 A M S A Anonima Materie Sint & Affini S P A Processo per la preparazione di refaximina k
CN103509038B (zh) * 2013-09-30 2016-01-20 浙江思贤制药有限公司 一种新晶型利福昔明ζ及其制备方法
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
CA2947962C (en) 2014-05-04 2024-01-16 Salix Pharmaceuticals, Inc. Ibs microbiota and uses thereof
JP6576953B2 (ja) 2014-05-12 2019-09-18 アルファシグマ ソシエタ ペル アチオニ リファキシミンの新規溶媒和物結晶形、生成物、組成物及びそれらの使用
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
EP4137132A1 (en) 2016-09-30 2023-02-22 Salix Pharmaceuticals, Inc. Solid dispersion forms of rifaximin
RU2020102511A (ru) * 2017-06-26 2021-07-27 Биофер С.П.А. Соединения пиридо-имидазо рифамицина в качестве антибактериального средства

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1154655B (it) 1980-05-22 1987-01-21 Alfa Farmaceutici Spa Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Also Published As

Publication number Publication date
ES8603489A1 (es) 1986-01-01
ES543115A0 (es) 1986-01-01
IE851191L (en) 1985-11-15
DK214685A (da) 1985-11-16
JPH0469634B2 (member.php) 1992-11-06
FI81101C (fi) 1990-09-10
EP0161534A3 (en) 1987-03-04
NO164242C (no) 1990-09-12
AU568934B2 (en) 1988-01-14
ATE46512T1 (de) 1989-10-15
US4557866A (en) 1985-12-10
IE58392B1 (en) 1993-09-08
NO851921L (no) 1985-11-18
IT1199374B (it) 1988-12-30
FI851907L (fi) 1985-11-16
FI851907A0 (fi) 1985-05-14
DE3573120D1 (en) 1989-10-26
FI81101B (fi) 1990-05-31
DK162647C (da) 1992-04-13
DK214685D0 (da) 1985-05-14
IT8403463A0 (it) 1984-05-15
DK162647B (da) 1991-11-25
GR851144B (member.php) 1985-11-25
JPS60252483A (ja) 1985-12-13
AR241913A1 (es) 1993-01-29
PT80446A (en) 1985-06-01
EP0161534A2 (en) 1985-11-21
CA1215708A (en) 1986-12-23
PH22007A (en) 1988-05-02
AU4251585A (en) 1985-11-21
PT80446B (pt) 1987-11-11
EP0161534B1 (en) 1989-09-20
NO164242B (no) 1990-06-05

Similar Documents

Publication Publication Date Title
ZA852971B (en) New process for the synthesis of pyrido-imidazo rifamycins
PT77327B (en) Process for the preparation of amnonia synthesis gas
DE3567672D1 (en) Process for the production of synthesis gas
GB2179366B (en) Process for the production of synthesis gas
DE3574011D1 (en) Process for the preparation of hydrocarbons
GB8427288D0 (en) Synthesis gas
RO82276B (ro) Procedeu de sinteza a cloroformiatilor alpha-clorurati
DE3571603D1 (en) Process for the synthesis of 2-methoxy-6-bromo-naphthalene
DE3261829D1 (en) Process for the synthesis of p-nitrophenetol
PT80447A (en) A new process for the synthesis of imidazo rifamycins
GB8400639D0 (en) Synthesis gas
PT81526A (en) Process for the preparation of new homopropargylamines
DE3664464D1 (en) Process for the manufacture of gamma-butyrolactames
GB8427289D0 (en) Synthesis gas
PT81198A (en) A new process for the synthesis of pyrido-imidazo-rifamycins
EG14914A (en) Method for the synthesis of alkoxyates of alkaline-carth metals
DE3567861D1 (en) Process for the preparation of tetrahydrofuran
DE3163241D1 (en) Process for the synthesis of metachlorophenols
DE3162997D1 (en) Process for the synthesis of metachlorophenols
GB2167752B (en) Process for synthesizing diorganomonothiophosphinates
DE3563742D1 (en) Process for the synthesis of aminonitropyridines
JPS57143359A (en) Manufacture of leucotriaryl methane compounds
DE3563607D1 (en) Process for the preparation of synthesis gas from methanol
GB2099846B (en) Process for the preparation of synthesis gas
DE3162998D1 (en) Process for the synthesis of metachlorophenols