ZA852971B - New process for the synthesis of pyrido-imidazo rifamycins - Google Patents
New process for the synthesis of pyrido-imidazo rifamycinsInfo
- Publication number
- ZA852971B ZA852971B ZA852971A ZA852971A ZA852971B ZA 852971 B ZA852971 B ZA 852971B ZA 852971 A ZA852971 A ZA 852971A ZA 852971 A ZA852971 A ZA 852971A ZA 852971 B ZA852971 B ZA 852971B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrido
- synthesis
- new process
- rifamycins
- imidazo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT03463/84A IT1199374B (it) | 1984-05-15 | 1984-05-15 | Processo per la preparazione di pirido-imidazo-rifamicine |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA852971B true ZA852971B (en) | 1985-12-24 |
Family
ID=11107845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA852971A ZA852971B (en) | 1984-05-15 | 1985-04-19 | New process for the synthesis of pyrido-imidazo rifamycins |
Country Status (18)
Country | Link |
---|---|
US (1) | US4557866A (fi) |
EP (1) | EP0161534B1 (fi) |
JP (1) | JPS60252483A (fi) |
AR (1) | AR241913A1 (fi) |
AT (1) | ATE46512T1 (fi) |
AU (1) | AU568934B2 (fi) |
CA (1) | CA1215708A (fi) |
DE (1) | DE3573120D1 (fi) |
DK (1) | DK162647C (fi) |
ES (1) | ES8603489A1 (fi) |
FI (1) | FI81101C (fi) |
GR (1) | GR851144B (fi) |
IE (1) | IE58392B1 (fi) |
IT (1) | IT1199374B (fi) |
NO (1) | NO164242C (fi) |
PH (1) | PH22007A (fi) |
PT (1) | PT80446B (fi) |
ZA (1) | ZA852971B (fi) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
WO2003051299A2 (en) * | 2001-12-13 | 2003-06-26 | Activbiotics, Inc. | Sulfhydryl rifamycins and uses thereof |
US7923553B2 (en) | 2003-11-07 | 2011-04-12 | Alfa Wassermann, S.P.A. | Processes for the production of polymorphic forms of rifaximin |
US7902206B2 (en) | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
US20080262024A1 (en) * | 2003-11-07 | 2008-10-23 | Giuseppe Claudio Viscomi | Rifaximin compositions and method of use |
US7906542B2 (en) | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
US20060210483A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections |
US8003118B2 (en) * | 2005-03-02 | 2011-08-23 | Kodsi Robert E | Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis |
US20060210492A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Use of rifaximin for treatment and prevention of periodontal conditions |
EP1698630B1 (en) * | 2005-03-03 | 2014-09-03 | ALFA WASSERMANN S.p.A. | New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations |
ITBO20050123A1 (it) | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
MX2008011305A (es) | 2006-03-09 | 2009-02-10 | Salix Pharmaceuticals Inc | Preparacion anti-disfunsion rectal con rifaximina. |
MX2009001342A (es) | 2006-08-02 | 2009-08-31 | Salix Pharmaceuticals Inc | Composiciones y metodos para el tratamiento de proctosigmoiditis por radiacion. |
ITMI20061692A1 (it) | 2006-09-05 | 2008-03-06 | Alfa Wassermann Spa | Uso di polioli per ottenere forme polimorfe stabili di rifaximina |
JP2010504314A (ja) * | 2006-09-22 | 2010-02-12 | シプラ・リミテッド | リファキシミン |
US20080159987A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Restless Legs Syndrome |
US20080161337A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Chronic Prostatitis |
ITMI20071241A1 (it) * | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
US7709634B2 (en) | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
KR101674382B1 (ko) | 2008-02-25 | 2016-11-09 | 샐릭스 파마슈티컬스 리미티드 | 리팍시민의 형태 및 이의 용도 |
US8486956B2 (en) * | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
MX2010009197A (es) | 2008-02-26 | 2010-11-22 | Salix Pharmaceuticals Ltd | Metodos para tratar padecimientos del intestino. |
US11779571B2 (en) | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
AU2009244190B2 (en) | 2008-05-07 | 2016-02-25 | Salix Pharmaceuticals, Ltd. | Methods of treating bowel disease by administering a bowel cleanser and an antibiotic |
CN101585843B (zh) * | 2008-05-21 | 2011-07-06 | 重庆赛诺生物药业股份有限公司 | 一种利福昔明的制备工艺 |
US20110035232A1 (en) | 2008-10-02 | 2011-02-10 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
PL3628319T3 (pl) | 2008-10-02 | 2024-04-29 | Salix Pharmaceuticals, Ltd. | Leczenie encefalopatii wątrobowej za pomocą ryfaksyminy |
US7928115B2 (en) | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
WO2010067072A1 (en) | 2008-12-10 | 2010-06-17 | Cipla Limited | Rifaximin complexes |
IT1397617B1 (it) * | 2009-04-20 | 2013-01-18 | Alfa Wassermann Spa | Nuovi derivati della rifamicina |
KR20190099100A (ko) | 2009-06-02 | 2019-08-23 | 샐릭스 파마슈티컬스 리미티드 | 간성 뇌병증의 치료방법 |
MX2012002895A (es) | 2009-09-13 | 2012-05-22 | Salix Pharmaceuticals Ltd | Metodos para tratar el sindrome de intestino irritado (ibs). |
MX2012005883A (es) | 2009-11-23 | 2012-10-09 | Cipla Ltd | Composicion topica en espuma. |
US8952159B2 (en) | 2009-12-28 | 2015-02-10 | Silvio Massimo Lavagna | Method for the production of amorphous rifaximin |
AU2011218129A1 (en) | 2010-02-18 | 2012-08-23 | Board Of Regents Of The University Of Texas System | Methods for treating infection |
IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
WO2011156897A2 (en) * | 2010-06-16 | 2011-12-22 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
EA033370B1 (ru) | 2010-07-12 | 2019-10-31 | Salix Pharmaceuticals Ltd | Составы рифаксимина и их применение |
WO2012035544A2 (en) | 2010-09-13 | 2012-03-22 | Sequent Scientific Ltd. | A novel polymorphic form of rifaximin and process for its preparation |
EP2672970B1 (en) | 2011-02-11 | 2018-08-01 | Salix Pharmaceuticals, Ltd. | Forms of rifaximin and uses thereof |
WO2012150561A1 (en) | 2011-05-02 | 2012-11-08 | Ranbaxy Laboratories Limited | Rifaximin dimethylformamide solvate |
WO2012155981A1 (en) | 2011-05-19 | 2012-11-22 | Friulchem Spa | New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby |
ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
CA2854380A1 (en) | 2011-11-02 | 2013-05-10 | Salix Pharmaceuticals, Ltd. | Methods for treating irritable bowel syndrome (ibs) and infections |
CA2876737A1 (en) | 2012-06-13 | 2013-12-19 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
WO2014140995A2 (en) | 2013-03-15 | 2014-09-18 | Alfa Wassermann S.P.A. | Method for diagnosing vaginal infections |
KR20150129691A (ko) | 2013-03-15 | 2015-11-20 | 알파 와셔만 에스.피.아. | 질 감염증의 치료에 사용하기 위한 리팍시민 |
JP6433980B2 (ja) | 2013-04-12 | 2018-12-05 | アルファシグマ ソシエタ ペル アチオニ | Nsaid投与並びに関連する組成物、方法及びシステム |
US9018225B1 (en) | 2013-07-26 | 2015-04-28 | Novel Laboratories | Rifaximin crystalline forms and methods of preparation thereof |
ITMI20131307A1 (it) | 2013-08-02 | 2015-02-02 | A M S A Anonima Materie Sint & Affini S P A | Processo per la preparazione di refaximina k |
CN103509038B (zh) * | 2013-09-30 | 2016-01-20 | 浙江思贤制药有限公司 | 一种新晶型利福昔明ζ及其制备方法 |
EP2927235B1 (en) | 2014-03-31 | 2017-02-08 | Euticals S.P.A. | Polymorphic mixture of rifaximin and its use for the preparation of solid formulations |
CA2947962C (en) | 2014-05-04 | 2024-01-16 | Salix Pharmaceuticals, Inc. | Ibs microbiota and uses thereof |
DK3143027T3 (da) | 2014-05-12 | 2019-08-12 | Alfasigma Spa | Ny solvatiseret krystalform af rifaximin, fremstilling, sammensætninger og anvendelser heraf |
EP2982764A1 (en) | 2014-08-05 | 2016-02-10 | ALFA WASSERMANN S.p.A. | Identification of vaginal bacteria |
US9988398B2 (en) | 2016-06-07 | 2018-06-05 | Cadila Healthcare Limited | Crystalline form of rifaximin and process for its preparation |
RS63751B1 (sr) | 2016-09-30 | 2022-12-30 | Salix Pharmaceuticals Inc | Čvrsti disperzioni oblici rifaksimina |
PL3645539T3 (pl) * | 2017-06-26 | 2021-10-25 | Biofer S.P.A. | Pochodne pirydoimidazoryfamycyny jako środek przeciwbakteryjny |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1154655B (it) * | 1980-05-22 | 1987-01-21 | Alfa Farmaceutici Spa | Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica |
-
1984
- 1984-05-15 IT IT03463/84A patent/IT1199374B/it active
-
1985
- 1985-04-19 ZA ZA852971A patent/ZA852971B/xx unknown
- 1985-04-19 EP EP85104790A patent/EP0161534B1/en not_active Expired
- 1985-04-19 DE DE8585104790T patent/DE3573120D1/de not_active Expired
- 1985-04-19 AT AT85104790T patent/ATE46512T1/de not_active IP Right Cessation
- 1985-04-25 PH PH32186A patent/PH22007A/en unknown
- 1985-04-26 US US06/727,521 patent/US4557866A/en not_active Expired - Lifetime
- 1985-04-29 CA CA000480321A patent/CA1215708A/en not_active Expired
- 1985-05-13 PT PT80446A patent/PT80446B/pt unknown
- 1985-05-13 GR GR851144A patent/GR851144B/el unknown
- 1985-05-14 ES ES543115A patent/ES8603489A1/es not_active Expired
- 1985-05-14 NO NO851921A patent/NO164242C/no not_active IP Right Cessation
- 1985-05-14 DK DK214685A patent/DK162647C/da not_active IP Right Cessation
- 1985-05-14 FI FI851907A patent/FI81101C/fi not_active IP Right Cessation
- 1985-05-14 IE IE119185A patent/IE58392B1/en not_active IP Right Cessation
- 1985-05-14 JP JP60102528A patent/JPS60252483A/ja active Granted
- 1985-05-15 AU AU42515/85A patent/AU568934B2/en not_active Expired
- 1985-05-15 AR AR85300385A patent/AR241913A1/es active
Also Published As
Publication number | Publication date |
---|---|
ES543115A0 (es) | 1986-01-01 |
US4557866A (en) | 1985-12-10 |
NO851921L (no) | 1985-11-18 |
DK214685A (da) | 1985-11-16 |
ES8603489A1 (es) | 1986-01-01 |
FI81101B (fi) | 1990-05-31 |
DE3573120D1 (en) | 1989-10-26 |
IE58392B1 (en) | 1993-09-08 |
PT80446A (en) | 1985-06-01 |
NO164242C (no) | 1990-09-12 |
IT1199374B (it) | 1988-12-30 |
FI851907A0 (fi) | 1985-05-14 |
DK162647B (da) | 1991-11-25 |
EP0161534B1 (en) | 1989-09-20 |
CA1215708A (en) | 1986-12-23 |
FI851907L (fi) | 1985-11-16 |
AU4251585A (en) | 1985-11-21 |
DK214685D0 (da) | 1985-05-14 |
GR851144B (fi) | 1985-11-25 |
EP0161534A2 (en) | 1985-11-21 |
PT80446B (pt) | 1987-11-11 |
AU568934B2 (en) | 1988-01-14 |
JPH0469634B2 (fi) | 1992-11-06 |
NO164242B (no) | 1990-06-05 |
DK162647C (da) | 1992-04-13 |
EP0161534A3 (en) | 1987-03-04 |
FI81101C (fi) | 1990-09-10 |
AR241913A1 (es) | 1993-01-29 |
PH22007A (en) | 1988-05-02 |
JPS60252483A (ja) | 1985-12-13 |
IE851191L (en) | 1985-11-15 |
IT8403463A0 (it) | 1984-05-15 |
ATE46512T1 (de) | 1989-10-15 |
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