ZA838436B - 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1h,5h-benzo(ij)quinolizine-2-carboxylic acid and derivatives - Google Patents
6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1h,5h-benzo(ij)quinolizine-2-carboxylic acid and derivativesInfo
- Publication number
- ZA838436B ZA838436B ZA838436A ZA838436A ZA838436B ZA 838436 B ZA838436 B ZA 838436B ZA 838436 A ZA838436 A ZA 838436A ZA 838436 A ZA838436 A ZA 838436A ZA 838436 B ZA838436 B ZA 838436B
- Authority
- ZA
- South Africa
- Prior art keywords
- quinolizine
- benzo
- dihydro
- oxo
- fluoro
- Prior art date
Links
- DXKRGNXUIRKXNR-UHFFFAOYSA-N ibafloxacin Chemical compound C1CC(C)N2C=C(C(O)=O)C(=O)C3=C2C1=C(C)C(F)=C3 DXKRGNXUIRKXNR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- -1 alkylaminoalkyl ester salts Chemical class 0.000 abstract 2
- 150000001263 acyl chlorides Chemical class 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/441,245 US4472405A (en) | 1982-11-12 | 1982-11-12 | Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA838436B true ZA838436B (en) | 1985-06-26 |
Family
ID=23752110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA838436A ZA838436B (en) | 1982-11-12 | 1983-11-11 | 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1h,5h-benzo(ij)quinolizine-2-carboxylic acid and derivatives |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4472405A (sv) |
| EP (1) | EP0109284B1 (sv) |
| JP (1) | JPH0826017B2 (sv) |
| KR (1) | KR890000864B1 (sv) |
| AT (1) | ATE39926T1 (sv) |
| AU (1) | AU568319B2 (sv) |
| CA (2) | CA1254568A (sv) |
| CS (1) | CS390391A3 (sv) |
| DE (1) | DE3378912D1 (sv) |
| EG (1) | EG16492A (sv) |
| ES (1) | ES527163A0 (sv) |
| FI (1) | FI73213C (sv) |
| GR (1) | GR79402B (sv) |
| IE (1) | IE56232B1 (sv) |
| IL (1) | IL70198A (sv) |
| IN (1) | IN161391B (sv) |
| MX (1) | MX7314E (sv) |
| NO (1) | NO160782C (sv) |
| NZ (1) | NZ206233A (sv) |
| OA (1) | OA07586A (sv) |
| PT (1) | PT77649B (sv) |
| ZA (1) | ZA838436B (sv) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3519926A1 (de) * | 1985-06-04 | 1986-12-04 | Bayer Ag | Indolinderivate, verfahren zu ihrer herstellung und diese indolinderivate enthaltende kosmetische lichtschutzmittel |
| US4898945A (en) * | 1986-01-22 | 1990-02-06 | Minnesota Mining And Manufacturing Company | Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid |
| CA1302413C (en) * | 1986-01-22 | 1992-06-02 | Bruce E. Williams | Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo- 1h,5h-benzo[ij]quinolizine-2-carboxylic acid |
| GB9827865D0 (en) * | 1998-12-18 | 1999-02-10 | Woodcock Fiona | Medicament |
| DE10312346A1 (de) * | 2003-03-20 | 2004-09-30 | Bayer Healthcare Ag | Kontrolliertes Freisetzungssystem |
| DE10351448A1 (de) | 2003-11-04 | 2005-06-09 | Bayer Healthcare Ag | Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften |
| DE102005055385A1 (de) * | 2004-12-09 | 2006-06-14 | Bayer Healthcare Ag | Arzneimittel zur hygienischen Applikation im Ohr |
| DE102006010642A1 (de) * | 2006-03-08 | 2007-09-27 | Bayer Healthcare Aktiengesellschaft | Arzneimittelformulierungen, enthaltend Fluorchinolone |
| DE102006010643A1 (de) | 2006-03-08 | 2007-09-13 | Bayer Healthcare Aktiengesellschaft | Arzneimittel enthaltend Fluorchinolone |
| DE102007026550A1 (de) | 2007-06-08 | 2008-12-11 | Bayer Healthcare Ag | Extrudate mit verbesserter Geschmacksmaskierung |
| DE102007055341A1 (de) | 2007-11-19 | 2009-05-20 | Bayer Animal Health Gmbh | Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren |
| WO2012049156A1 (en) | 2010-10-12 | 2012-04-19 | Bayer Animal Health Gmbh | Non-starch based soft chewables |
| CN105025885B (zh) | 2012-12-19 | 2022-04-08 | 拜耳动物保健有限责任公司 | 具有改善的接受性和良好贮存稳定性的片剂 |
| MD4291C1 (ro) * | 2013-12-27 | 2015-02-28 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Preparat medicamentos pentru tratamentul otitelor |
| EP4025220A4 (en) * | 2019-09-06 | 2023-10-04 | Elanco US Inc. | TASTY VETERINARY MEDICINAL COMPOSITIONS IN GRANULE FORM |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE793524A (fr) * | 1971-12-30 | 1973-06-29 | Riker Laboratories Inc | Acides benzoquinolizine-carboxyliques et leurs derives |
| ZA728444B (en) * | 1971-12-30 | 1973-10-31 | Riker Laboratories Inc | Substituted benzo(ij)quinolizine-2-carboxylic acids and derivatives thereof |
| JPS5630964A (en) * | 1979-08-22 | 1981-03-28 | Kyorin Pharmaceut Co Ltd | Novel substituted quinolinecarboxylic acid and its preparation |
| JPS5655388A (en) | 1979-10-11 | 1981-05-15 | Otsuka Pharmaceut Co Ltd | Benzo ij quinolidine-2-carboxylic acid derivative, and its preparation |
| US4301289A (en) * | 1980-02-19 | 1981-11-17 | Minnesota Mining And Manufacturing Company | Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid |
| JPS59155381A (ja) * | 1983-02-22 | 1984-09-04 | Kyorin Pharmaceut Co Ltd | ベンゾキノリジンカルボン酸誘導体及びその製造法 |
-
1982
- 1982-11-12 US US06/441,245 patent/US4472405A/en not_active Expired - Lifetime
-
1983
- 1983-10-27 CA CA000439826A patent/CA1254568A/en not_active Expired
- 1983-11-09 NO NO834093A patent/NO160782C/no unknown
- 1983-11-10 OA OA58156A patent/OA07586A/xx unknown
- 1983-11-10 ES ES527163A patent/ES527163A0/es active Granted
- 1983-11-11 ZA ZA838436A patent/ZA838436B/xx unknown
- 1983-11-11 NZ NZ206233A patent/NZ206233A/en unknown
- 1983-11-11 IN IN1382/CAL/83A patent/IN161391B/en unknown
- 1983-11-11 JP JP58212306A patent/JPH0826017B2/ja not_active Expired - Lifetime
- 1983-11-11 MX MX8310883U patent/MX7314E/es unknown
- 1983-11-11 DE DE8383306908T patent/DE3378912D1/de not_active Expired
- 1983-11-11 IE IE2639/83A patent/IE56232B1/en not_active IP Right Cessation
- 1983-11-11 PT PT77649A patent/PT77649B/pt not_active IP Right Cessation
- 1983-11-11 AU AU21181/83A patent/AU568319B2/en not_active Ceased
- 1983-11-11 AT AT83306908T patent/ATE39926T1/de not_active IP Right Cessation
- 1983-11-11 GR GR72947A patent/GR79402B/el unknown
- 1983-11-11 FI FI834147A patent/FI73213C/sv not_active IP Right Cessation
- 1983-11-11 IL IL70198A patent/IL70198A/xx not_active IP Right Cessation
- 1983-11-11 EP EP83306908A patent/EP0109284B1/en not_active Expired
- 1983-11-12 KR KR1019830005376A patent/KR890000864B1/ko not_active IP Right Cessation
- 1983-11-12 EG EG70383A patent/EG16492A/xx active
-
1988
- 1988-08-05 CA CA000574069A patent/CA1280755C/en not_active Expired - Fee Related
-
1991
- 1991-12-19 CS CS913903A patent/CS390391A3/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0826017B2 (ja) | 1996-03-13 |
| IE832639L (en) | 1984-05-12 |
| ES8504727A1 (es) | 1985-05-01 |
| EG16492A (en) | 1994-11-30 |
| GR79402B (sv) | 1984-10-22 |
| OA07586A (fr) | 1985-03-31 |
| NO160782B (no) | 1989-02-20 |
| NO834093L (no) | 1984-05-14 |
| DE3378912D1 (de) | 1989-02-16 |
| PT77649A (en) | 1983-12-01 |
| IE56232B1 (en) | 1991-05-22 |
| KR840006659A (ko) | 1984-12-01 |
| CS390391A3 (en) | 1992-09-16 |
| NZ206233A (en) | 1986-10-08 |
| PT77649B (en) | 1986-03-19 |
| FI834147A0 (fi) | 1983-11-11 |
| CA1254568A (en) | 1989-05-23 |
| EP0109284A1 (en) | 1984-05-23 |
| JPS59112969A (ja) | 1984-06-29 |
| ES527163A0 (es) | 1985-05-01 |
| ATE39926T1 (de) | 1989-01-15 |
| IN161391B (sv) | 1987-11-28 |
| FI73213B (fi) | 1987-05-29 |
| NO160782C (no) | 1989-05-31 |
| EP0109284B1 (en) | 1989-01-11 |
| MX7314E (es) | 1988-05-11 |
| IL70198A (en) | 1988-11-15 |
| KR890000864B1 (ko) | 1989-04-11 |
| IL70198A0 (en) | 1984-02-29 |
| CA1280755C (en) | 1991-02-26 |
| AU2118183A (en) | 1984-05-17 |
| US4472405A (en) | 1984-09-18 |
| AU568319B2 (en) | 1987-12-24 |
| FI834147A (fi) | 1984-05-13 |
| FI73213C (sv) | 1987-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EG16492A (en) | Method of preparing of 6,7 - dihydro - 5,8 - dimethyl -9- fluro -1- oxo -1h,5h - benzo (ij) quinolizine -2- carboxylic acid and derivatives | |
| PT80773A (en) | Process for the preparation of substituted benzoate ester prodrug derivatives of 3-hydroxymorfinans intermediates thereto and of pharmaceutical compositions containing the same | |
| NO173547C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater | |
| ES8702405A1 (es) | Procedimiento para la obtencion de acidos benzo(ij) quinolizina-2-carboxilicos y sus derivados | |
| DK159778A (da) | Forbindelsesstik til flade traadkabler | |
| NO301372B1 (no) | Fremgangsmåte for fremstilling av et farmasöytisk tålbart salt av klavulansyre | |
| JPS57108066A (en) | 4-substituted-2-oxoazetidine derivative and its preparation | |
| ES2001852A6 (es) | Procedimiento para preparar un derivado de acido quinolocarboxilico | |
| SE8301687D0 (sv) | 8-cyano-6,7-dihydro-5-metyl-1-oxo-1h-,5h-benso(ij)kinolizin-2-karboxylsyror och forfarande for framstellning derav | |
| AU4478489A (en) | Intermediates for the preparation of penem derivatives | |
| NO164243C (no) | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive 16,17-acetalsubstituerte pregnan-21-oinsyrederivater | |
| GB2102812B (en) | Therapeutically active compounds from species of rubia synthetic derivatives thereof, methods for the production thereof and pharmaceutical compositions comprising the same | |
| DK550183A (da) | 6,7-dihydro-5,8-dimethyl-9-fluor-1-oxo-1h,5h-benzo/ij/-quinolizin-2-carboxylsyre, fremgangsmaade til fremstilling deraf og mellemprodukter til brug ved udoevelse af fremgangsmaaden | |
| JPS57203067A (en) | Novel quinolinecarboxylic acid derivatives, their preparations, and antibacterial agent comprising them as active ingredient | |
| IT1101667B (it) | Esteri 3-fenossi-alfa-vinil-benzilici di acidi vinil-ciclopropan-carbossilici, procedimento per la loro preparatione e loro impiego per combattere organismi nocivi | |
| JPS57146775A (en) | 1,8-naphthyridine derivative and its salt | |
| JPS57183737A (en) | Use of phenylaliphatic carboxylic acid derivative as drug | |
| PH20548A (en) | Novel penem compounds,pharmaceutical compositions containing them and method of using said compounds | |
| NO915055D0 (no) | Fremgangsmaate for fremstilling av enantiomerisk rene tienopyranderivater | |
| GB2011887A (en) | Antiallergic agent | |
| ES509154A0 (es) | Un procedimiento para la preparacion de nuevos derivados del acido &-glutamil-diaminopimelilo. | |
| IL51296A0 (en) | Pharmaceutical compositions comprising quinuclidine carboxylic acid derivatives | |
| HRP921328B1 (en) | Process for the preparation of cyclopropanecarboxyle acid ester derivatives | |
| LV5479A3 (lv) | Hinolina atvasinajumu vai to farmaceitiski pienemamu esteru vai farmaceitiski pienemamu skabes aditivo salu iegusanas metode | |
| JPS53147095A (en) | Pyrazino(2,3-f)quinoline derivative |