ZA836949B - Piperazine derivatives with anticholinergic and/or antihistaminic activity - Google Patents

Piperazine derivatives with anticholinergic and/or antihistaminic activity

Info

Publication number
ZA836949B
ZA836949B ZA836949A ZA836949A ZA836949B ZA 836949 B ZA836949 B ZA 836949B ZA 836949 A ZA836949 A ZA 836949A ZA 836949 A ZA836949 A ZA 836949A ZA 836949 B ZA836949 B ZA 836949B
Authority
ZA
South Africa
Prior art keywords
anticholinergic
piperazine derivatives
antihistaminic activity
antihistaminic
activity
Prior art date
Application number
ZA836949A
Other languages
English (en)
Inventor
Carlo Milani
Giovanni Maria Carminati
Attilio Sovera
Original Assignee
Selvi & C Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selvi & C Spa filed Critical Selvi & C Spa
Publication of ZA836949B publication Critical patent/ZA836949B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA836949A 1982-09-27 1983-09-19 Piperazine derivatives with anticholinergic and/or antihistaminic activity ZA836949B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/424,512 US4457931A (en) 1982-09-27 1982-09-27 Piperazine derivatives with anticholinergic and/or antihistaminic activity

Publications (1)

Publication Number Publication Date
ZA836949B true ZA836949B (en) 1984-05-30

Family

ID=23682887

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA836949A ZA836949B (en) 1982-09-27 1983-09-19 Piperazine derivatives with anticholinergic and/or antihistaminic activity

Country Status (10)

Country Link
US (1) US4457931A (fr)
JP (1) JPS5989665A (fr)
BE (1) BE897828A (fr)
DE (1) DE3334757A1 (fr)
ES (3) ES8604543A1 (fr)
FR (1) FR2533564B1 (fr)
GB (1) GB2135991B (fr)
IT (1) IT1212088B (fr)
NL (1) NL8303311A (fr)
ZA (1) ZA836949B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6147466A (ja) * 1984-08-10 1986-03-07 Dainippon Pharmaceut Co Ltd アミン誘導体
FR2573075B1 (fr) * 1984-09-14 1987-03-20 Innothera Lab Sa Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique
JPS6314083A (ja) * 1986-06-28 1988-01-21 Nippon Denso Co Ltd 積層型熱交換器
EP0350145A3 (fr) * 1988-04-28 1990-07-04 Yamanouchi Pharmaceutical Co. Ltd. Derivés de Pyridylthiazolidine carboxamide et intermédiaires et leur production
GB2227018B (en) * 1989-01-13 1992-05-20 Wyeth John & Brother Ltd Piperazinylalkylcarboxylic acid adamantylamides
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
GB9817197D0 (en) * 1998-08-07 1998-10-07 Lilly Co Eli Pharmaceutical compounds
JP2005502623A (ja) * 2001-07-02 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ 置換ピペラジンおよびジアゼパン
CN101404986B (zh) * 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
US7456222B2 (en) * 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
US20040033986A1 (en) * 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
AU2004265243A1 (en) * 2003-06-20 2005-02-24 Arena Pharmaceuticals, Inc. N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5HT2c receptor associated diseases
WO2005034857A2 (fr) * 2003-09-05 2005-04-21 Sequella, Inc. Procedes et compositions renfermant des diamines comme nouveaux produits therapeutiques antituberculeux
WO2006064780A1 (fr) * 2004-12-14 2006-06-22 Shionogi & Co., Ltd. Agent therapeutique pour la constipation
US20090281054A1 (en) * 2008-05-06 2009-11-12 Venkata Reddy Compositions and methods comprising capuramycin analogues

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR997607A (fr) * 1949-10-14 1952-01-08 American Cyanamid Co Perfectionnements relatifs aux pipérazines substituées
US2794804A (en) * 1955-03-24 1957-06-04 American Cyanamid Co Substituted piperazines and method of preparing the same
BE637271A (fr) * 1963-04-04 1900-01-01
US3712893A (en) * 1969-11-10 1973-01-23 Cerm Cent Europ Rech Mauvernay Butyl-piperazine derivatives
JPS49101383A (fr) * 1973-02-05 1974-09-25
JPS517673A (ja) * 1974-07-08 1976-01-22 Hitachi Ltd Hansoshisutemu
JPS5111635A (fr) * 1974-07-18 1976-01-29 Hideji Kitamura
FR2306694A1 (fr) * 1975-04-07 1976-11-05 Parcor Derives de la piperazine
JPS523387A (en) * 1975-06-24 1977-01-11 Nec Home Electronics Ltd Manufacturing method of semiconductor device
JPS54103893A (en) * 1978-01-26 1979-08-15 Morishita Pharma 1*44benzodioxane derivative
AU532411B2 (en) * 1979-03-01 1983-09-29 Duphar International Research B.V. Phenyl piperazine derivatives
JPS5827793B2 (ja) * 1980-09-18 1983-06-11 住友化学工業株式会社 新規なアニリン誘導体の製法
JPS5761149A (en) * 1980-09-30 1982-04-13 Matsushita Electric Works Ltd Staircase

Also Published As

Publication number Publication date
JPS5989665A (ja) 1984-05-23
ES542946A0 (es) 1986-01-01
IT1212088B (it) 1989-11-08
NL8303311A (nl) 1984-04-16
ES8603442A1 (es) 1986-01-01
ES8603443A1 (es) 1986-01-01
GB2135991B (en) 1985-12-04
FR2533564B1 (fr) 1986-10-03
ES525953A0 (es) 1986-02-01
ES542947A0 (es) 1986-01-01
US4457931A (en) 1984-07-03
BE897828A (nl) 1984-01-16
GB8325839D0 (en) 1983-10-26
JPS6139289B2 (fr) 1986-09-03
FR2533564A1 (fr) 1984-03-30
GB2135991A (en) 1984-09-12
IT8322784A0 (it) 1983-09-06
DE3334757A1 (de) 1984-03-29
ES8604543A1 (es) 1986-02-01

Similar Documents

Publication Publication Date Title
GB2163432B (en) Piperazine derivatives
GB2146333B (en) Piperazine derivatives
DE3567459D1 (en) Benzothiazole and benzothiophene derivatives
ZW13185A1 (en) Heterocyclic derivatives
GB2157685B (en) Piperazine derivatives
EP0292437A3 (en) Piperidylaminotriazine derivatives and their use as stabilizers
ZA836949B (en) Piperazine derivatives with anticholinergic and/or antihistaminic activity
GB2117377B (en) Piperidine derivatives and use thereof as stabilizers for polymers
JPS6452773A (en) Heterocyclic hydroxyethylazole
GB2067562B (en) Cinnamoyl piperazines derivatives
GB2143235B (en) 1-pyridyl-alkyl-4-aryl piperazine derivatives
GB8319317D0 (en) Piperazine derivatives and salts
EG17820A (en) Peptide-substituted heterocyclic emminostimulants
EP0218206A3 (en) Compounds with piperazine rests
GB8304488D0 (en) Piperazine and homopiperazine derivatives
GB2162843B (en) Piperazine derivatives
GB2223753B (en) Piperazine derivatives
PH23442A (en) Cephalosporin derivatives and salts thereof
GB2224027B (en) Piperazine derivatives
PH21201A (en) Cephalosporin derivatives and salts thereof
DE3566257D1 (en) Piperazine derivatives
PH22051A (en) Antiallergic imidodisulfamides and use thereof
GB2139216B (en) Heterocyclic medicaments
IE841732L (en) Heterocyclic sulphonylureas
IE831502L (en) Piperazine derivatives