ZA835237B - New derivatives of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,a process for their preparation,agents containing these derivatives and the use thereof,and of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,as an intermediate stage and a process for the preparation thereof - Google Patents

New derivatives of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,a process for their preparation,agents containing these derivatives and the use thereof,and of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,as an intermediate stage and a process for the preparation thereof

Info

Publication number
ZA835237B
ZA835237B ZA835237A ZA835237A ZA835237B ZA 835237 B ZA835237 B ZA 835237B ZA 835237 A ZA835237 A ZA 835237A ZA 835237 A ZA835237 A ZA 835237A ZA 835237 B ZA835237 B ZA 835237B
Authority
ZA
South Africa
Prior art keywords
azabicyclo
octane
preparation
carboxylic acid
derivatives
Prior art date
Application number
ZA835237A
Other languages
English (en)
Inventor
Rainer Henning
Hansjoerg Urbach
Reinhard Becker
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA835237B publication Critical patent/ZA835237B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA835237A 1982-07-20 1983-07-19 New derivatives of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,a process for their preparation,agents containing these derivatives and the use thereof,and of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,as an intermediate stage and a process for the preparation thereof ZA835237B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823227055 DE3227055A1 (de) 1982-07-20 1982-07-20 Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ZA835237B true ZA835237B (en) 1984-03-28

Family

ID=6168834

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA835237A ZA835237B (en) 1982-07-20 1983-07-19 New derivatives of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,a process for their preparation,agents containing these derivatives and the use thereof,and of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,as an intermediate stage and a process for the preparation thereof

Country Status (13)

Country Link
EP (1) EP0105102A1 (fi)
JP (1) JPS5929686A (fi)
KR (1) KR840005429A (fi)
AU (1) AU1699383A (fi)
DE (1) DE3227055A1 (fi)
DK (1) DK333083A (fi)
ES (2) ES524214A0 (fi)
FI (1) FI832602A (fi)
GR (1) GR78901B (fi)
IL (1) IL69271A0 (fi)
NO (1) NO832648L (fi)
PT (1) PT77058B (fi)
ZA (1) ZA835237B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
FR2619813B1 (fr) * 1987-08-28 1991-05-03 Adir Nouveaux derives de l'acide aza - 2 bicyclooctane carboxylique - 3, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
WO1990002123A1 (en) * 1988-08-23 1990-03-08 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
FR2635684A1 (fr) * 1988-08-24 1990-03-02 Adir Utilisation de derives de l'acide aza - 2 bicyclooctane (2.2.2) carboxylique - 3 pour l'obtention de medicaments destines au traitement des maladies consecutives a l'alteration de la paroi vasculaire ainsi qu'aux troubles de la microcirculation
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
FR2655989B1 (fr) * 1989-12-20 1992-02-28 Adir Nouveaux derives d'amino-acides substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
ATE212990T1 (de) 1996-03-20 2002-02-15 Hoechst Ag Inhibitoren der knochenresorption und vitronectinrezeptor-antagonisten
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
SE0000382D0 (sv) 2000-02-07 2000-02-07 Astrazeneca Ab New process
WO2002000617A2 (en) * 2000-06-28 2002-01-03 Bristol-Myers Squibb Company Selective androgen receptor modulators and methods for their identification, design and use
US20030114420A1 (en) * 2000-06-28 2003-06-19 Salvati Mark E. Fused cyclic modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3177311D1 (de) * 1980-08-30 1994-06-09 Hoechst Ag Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung.
FR2492381A1 (fr) * 1980-10-21 1982-04-23 Science Union & Cie Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme

Also Published As

Publication number Publication date
ES8404351A1 (es) 1984-05-01
DK333083A (da) 1984-01-21
PT77058B (de) 1986-02-26
NO832648L (no) 1984-01-23
DK333083D0 (da) 1983-07-19
ES8404352A1 (es) 1984-05-01
FI832602A0 (fi) 1983-07-18
ES524214A0 (es) 1984-05-01
FI832602A (fi) 1984-01-21
KR840005429A (ko) 1984-11-12
ES524215A0 (es) 1984-05-01
DE3227055A1 (de) 1984-01-26
IL69271A0 (en) 1983-11-30
PT77058A (de) 1983-08-01
JPS5929686A (ja) 1984-02-16
GR78901B (fi) 1984-10-02
AU1699383A (en) 1984-01-26
EP0105102A1 (de) 1984-04-11

Similar Documents

Publication Publication Date Title
ZA835237B (en) New derivatives of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,a process for their preparation,agents containing these derivatives and the use thereof,and of 2-azabicyclo(2.2.2)octane-3-carboxylic acid,as an intermediate stage and a process for the preparation thereof
AU627741B2 (en) Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof
DE3368060D1 (en) O-halobenzoic acid derivatives, process for their preparation, herbicidal compositions and their use
DE3061347D1 (en) 2,4,6-triiodo-isophthalic acid derivatives, process for their preparation and x-ray contrast agents containing them
DE3361803D1 (en) Process for the preparation of (2,2)-paracyclophane
DE3374686D1 (en) 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
ZA828085B (en) Derivatives of cis,endo-2-azabicyclo-(3.3.0)-octane-3-carboxylic acid,a process for their preparation,agents containing these compounds and their use
EP0107693A4 (de) 2,3,4-trinor-1,5-inter-m-phenylen-prostacyclin-i2-analoge, verfahren zu deren herstellung sowie diese verbindungen enthaltende pharmazeutische präparate.
DE3466540D1 (en) Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
PT76870A (en) Process for the preparation of 1,4-dihydropiridine derivatives and pharmaceutical compositions containing them
IL91986A0 (en) 2-azabicyclo(2.2.1)hept-5-ene-2-acetic acid,derivatives thereof and related compounds,process for the preparation of said compounds and the use of said compounds for the manufacture of n-phosphonomethylglycine
EP0113880A3 (en) Derivatives from 2-azabicyclo(2.2.1)heptane, process for their preparation, agents containing them and their use, and 2-azabicyclo(2.2.1)heptane derivatives as intermediates, and process for their preparation
IL59760A (en) Method for the preparation of 7-oxo-4-thia-1-aza-bicyclo(3,2,0)-heptane-2-carboxylic acid derivatives
DE3365690D1 (en) Process for the preparation of 3,4,9,10-tetrathioperylene and 3,4,9,10-tetraselenoperylene
DE3266439D1 (en) Process for the preparation of 1,3-disubstituted-2-oxo-4,5-imidazolinedicarboxylic acid
HUT35471A (en) Herbicide preparations containing antidote of n-/dichlor-acetyl/-n-substituted.glycine-n', n-disubstituted-amide-type, or containing agent and antidote, as well as process for the production of the antidote
IL66277A (en) 3,7-dialkyl-3,7-diazabicyclo(3.3.1)nonan-9-ol derivatives,a process for the preparation thereof and pharmaceutical compositions containing them
ZA844269B (en) Bicyclo(3.2.1)octane carboxylic acid derivatives,process for their preparation and therapeutic application thereof
PT74400B (en) Process for the preparation of 17,18-dehydro-apovincaminol-3', 4',5'-trimethoxy-benzoate and of pharmaceutical compositions containing them
DE3368046D1 (en) Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same
ZA815988B (en) Aminoacid derivatives,a process for their preparation,agents containing these compounds,and the use thereof
GB2137987B (en) Process for the preparation of 3,4-dihydro-2-substituted-2h-1,2-benzothiazine-carboxylic acid 1,1-dioxide derivatives
EP0099071A3 (en) Process for the preparation of monoaroylated 1,4-diaminoanthraquinones
ZA838815B (en) Process for the preparation of n,n'-diformylhydrazine
DE3470161D1 (en) Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide