ES8404351A1 - Procedimiento para la preparacion de nuevos derivados de acido 2-aza-biciclo(2.2.2)octan-3-carboxilico - Google Patents

Procedimiento para la preparacion de nuevos derivados de acido 2-aza-biciclo(2.2.2)octan-3-carboxilico

Info

Publication number
ES8404351A1
ES8404351A1 ES524214A ES524214A ES8404351A1 ES 8404351 A1 ES8404351 A1 ES 8404351A1 ES 524214 A ES524214 A ES 524214A ES 524214 A ES524214 A ES 524214A ES 8404351 A1 ES8404351 A1 ES 8404351A1
Authority
ES
Spain
Prior art keywords
aza
bicyclo
octane
preparation
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524214A
Other languages
English (en)
Other versions
ES524214A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8404351A1 publication Critical patent/ES8404351A1/es
Publication of ES524214A0 publication Critical patent/ES524214A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL ACIDO 2-AZA-BICICLO2.2.2OCTAN-3-CARBOXILICO , DE FORMULA GENERAL (I), EN LA QUE N ES 0 O 1; R ES HIDROGENO, ALCOHILO O ARALCOILO CON 7 A 9 ATOMOS DE CARBONO; R ES HIDROGENO O HIDROXILO; Z ES HIDROGENO; Y X ES ALCOHILO, ALQUENILO O CICLOALCOHILO, Y SUS SALES FISIOLOGICAMENTE INOCUAS.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE N, R, R, X, Y Y Z TIENEN LOS SIGNIFICADOS YA INDICADOS, CON UN COMPUESTO DE FORMULA (III), EN LA QUE W SIGNIFICA HIDROGENO O UN RADICAL SEPARABLE EN CONDICIONES ACIDAS O HIDROGENOLITICAMENTE.DEAPLICACION EN LA LUCHA CONTRA LA HIPERTENSION DE DIVERSOS ORIGEN
ES524214A 1982-07-20 1983-07-18 Procedimiento para la preparacion de nuevos derivados de acido 2-aza-biciclo(2.2.2)octan-3-carboxilico Granted ES524214A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823227055 DE3227055A1 (de) 1982-07-20 1982-07-20 Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
ES8404351A1 true ES8404351A1 (es) 1984-05-01
ES524214A0 ES524214A0 (es) 1984-05-01

Family

ID=6168834

Family Applications (2)

Application Number Title Priority Date Filing Date
ES524214A Granted ES524214A0 (es) 1982-07-20 1983-07-18 Procedimiento para la preparacion de nuevos derivados de acido 2-aza-biciclo(2.2.2)octan-3-carboxilico
ES524215A Expired ES8404352A1 (es) 1982-07-20 1983-07-18 Procedimiento para la preparacion de nuevos derivados de acido 2-aza-biciclo(2.2.2)octan-3-carboxilico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES524215A Expired ES8404352A1 (es) 1982-07-20 1983-07-18 Procedimiento para la preparacion de nuevos derivados de acido 2-aza-biciclo(2.2.2)octan-3-carboxilico

Country Status (13)

Country Link
EP (1) EP0105102A1 (es)
JP (1) JPS5929686A (es)
KR (1) KR840005429A (es)
AU (1) AU1699383A (es)
DE (1) DE3227055A1 (es)
DK (1) DK333083A (es)
ES (2) ES524214A0 (es)
FI (1) FI832602A (es)
GR (1) GR78901B (es)
IL (1) IL69271A0 (es)
NO (1) NO832648L (es)
PT (1) PT77058B (es)
ZA (1) ZA835237B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
FR2619813B1 (fr) * 1987-08-28 1991-05-03 Adir Nouveaux derives de l'acide aza - 2 bicyclooctane carboxylique - 3, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
WO1990002123A1 (en) * 1988-08-23 1990-03-08 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
FR2635684A1 (fr) * 1988-08-24 1990-03-02 Adir Utilisation de derives de l'acide aza - 2 bicyclooctane (2.2.2) carboxylique - 3 pour l'obtention de medicaments destines au traitement des maladies consecutives a l'alteration de la paroi vasculaire ainsi qu'aux troubles de la microcirculation
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
FR2655989B1 (fr) * 1989-12-20 1992-02-28 Adir Nouveaux derives d'amino-acides substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES2171768T3 (es) 1996-03-20 2002-09-16 Hoechst Ag Inhibidores de la resorcion osea y antagonistas de receptores de vitronectina.
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
SE0000382D0 (sv) 2000-02-07 2000-02-07 Astrazeneca Ab New process
CA2413417A1 (en) * 2000-06-28 2002-01-03 Bristol-Myers Squibb Company Selective androgen receptor modulators and methods for their identification, design and use
US20030114420A1 (en) * 2000-06-28 2003-06-19 Salvati Mark E. Fused cyclic modulators of nuclear hormone receptor function
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278530A3 (de) * 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
FR2492381A1 (fr) * 1980-10-21 1982-04-23 Science Union & Cie Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme

Also Published As

Publication number Publication date
IL69271A0 (en) 1983-11-30
JPS5929686A (ja) 1984-02-16
DE3227055A1 (de) 1984-01-26
FI832602A0 (fi) 1983-07-18
KR840005429A (ko) 1984-11-12
PT77058A (de) 1983-08-01
EP0105102A1 (de) 1984-04-11
DK333083D0 (da) 1983-07-19
ES524215A0 (es) 1984-05-01
ZA835237B (en) 1984-03-28
AU1699383A (en) 1984-01-26
NO832648L (no) 1984-01-23
DK333083A (da) 1984-01-21
PT77058B (de) 1986-02-26
FI832602A (fi) 1984-01-21
GR78901B (es) 1984-10-02
ES524214A0 (es) 1984-05-01
ES8404352A1 (es) 1984-05-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980102