ZA833174B - Human tissue plasminogen activator - Google Patents

Human tissue plasminogen activator

Info

Publication number
ZA833174B
ZA833174B ZA833174A ZA833174A ZA833174B ZA 833174 B ZA833174 B ZA 833174B ZA 833174 A ZA833174 A ZA 833174A ZA 833174 A ZA833174 A ZA 833174A ZA 833174 B ZA833174 B ZA 833174B
Authority
ZA
South Africa
Prior art keywords
plasminogen activator
human tissue
tissue plasminogen
human
activator
Prior art date
Application number
ZA833174A
Other languages
English (en)
Inventor
David Van Norman Goeddel
William Jack Kohr
Diane Pennica
Gordon Allen Vehar
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23478488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA833174(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ZA833174B publication Critical patent/ZA833174B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
ZA833174A 1982-05-05 1983-05-04 Human tissue plasminogen activator ZA833174B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05

Publications (1)

Publication Number Publication Date
ZA833174B true ZA833174B (en) 1984-08-29

Family

ID=23478488

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA833174A ZA833174B (en) 1982-05-05 1983-05-04 Human tissue plasminogen activator

Country Status (8)

Country Link
US (1) US5763253A (ja)
JP (2) JPS5942321A (ja)
KR (1) KR840004781A (ja)
GT (1) GT198302091A (ja)
HU (1) HU200615B (ja)
MX (1) MX197183A (ja)
SU (1) SU1662352A3 (ja)
ZA (1) ZA833174B (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
JP2648301B2 (ja) * 1983-12-27 1997-08-27 ジエネテイツクス・インスチチユ−ト・インコ−ポレ−テツド 真核細胞の形質転換のための補助ｄｎａを含むベクター
JPS60158117A (ja) * 1984-01-30 1985-08-19 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
NO175158C (no) * 1984-10-01 1994-09-07 Genzyme Corp Fremstilling av human livmorsvevplasminogenaktivator med rekombinant-DNA
EP0199801B1 (en) * 1984-10-29 1993-08-25 MICROGENICS CORPORATION (a Delaware corporation) Methods for protein binding enzyme complementation assays
IL78571A (en) * 1985-04-22 1991-06-30 Genentech Inc Human tissue plasminogen activator mutants resistant to enzymatic cleavage resulting in two-chain form
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
AU593264B2 (en) 1985-07-10 1990-02-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
NL8503097A (nl) * 1985-11-11 1987-06-01 Leuven Res & Dev Vzw Geneesmiddel met thrombolytische werking.
AU6733287A (en) * 1985-11-13 1987-06-02 Murphy, J.R. Cys codon-modified dna
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
JP2837348B2 (ja) * 1985-11-27 1998-12-16 三井化学株式会社 ヒト正常細胞由来のヒト組織プラスミノーゲン活性化因子の製造方法
AU605124B2 (en) * 1985-12-23 1991-01-10 Behringwerke Aktiengesellschaft Novel peptide plasminogen activators
JPS62269697A (ja) * 1986-05-19 1987-11-24 Snow Brand Milk Prod Co Ltd エリスロポエチンの製造方法
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
JPH01500322A (ja) * 1986-03-28 1989-02-09 クリエイティブ　バイオモレクレス，インコーポレーテッド 組織プラスミノーゲンアクテイベーター類縁蛋白質
JPS63196268A (ja) * 1987-02-10 1988-08-15 Kanegafuchi Chem Ind Co Ltd 無血清培地で継代増殖可能な形質転換細胞、その育種方法およびその細胞による蛋白質の生産方法
JPH084502B2 (ja) * 1987-03-20 1996-01-24 エーザイ株式会社 複合変異ｔＰＡ
DE3853479T2 (de) * 1987-06-24 1995-09-28 Genentech Inc Ausgeglichenes, konstitutives, induzierbares transkriptionssystem.
CN1026994C (zh) * 1987-07-28 1994-12-14 吉斯特布罗卡德斯股份有限公司 在克鲁维酵母宿主生产所需肽的方法
JP2576200B2 (ja) * 1988-03-09 1997-01-29 味の素株式会社 生理活性タンパク質の製造法
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL43343A (en) * 1972-10-24 1976-03-31 Lilly Co Eli Production of plasminogen activator
US3904480A (en) * 1972-10-24 1975-09-09 Lilly Co Eli Enhanced production of plasminogen activator
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (ja) * 1973-12-03 1977-11-04 Fabre Sa Pierre
FR2310133A2 (fr) * 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne
US4245051A (en) * 1978-03-30 1981-01-13 Rockefeller University Human serum plasminogen activator
US4190708A (en) * 1978-05-24 1980-02-26 Monsanto Company Production of urokinase
CH643297A5 (de) * 1978-06-30 1984-05-30 Alpha Patent Ltd Verfahren zur reindarstellung von urokinase.
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
ES494343A0 (es) * 1979-07-27 1981-10-01 Procedimiento de obtencion de un activador del plasminogeno
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS57106640A (en) * 1980-12-25 1982-07-02 Idemitsu Kosan Co Ltd Preparation of carboxylates
US4853330A (en) * 1983-04-07 1989-08-01 Genentech, Inc. Human tissue plasminogen activator
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
US5011795A (en) * 1983-01-19 1991-04-30 Genentech, Inc. Human tPA production using vectors coding for DHFR protein
EP0174835A1 (en) * 1984-09-11 1986-03-19 The Upjohn Company Human tissue plasminogen activator and recombinant DNA compounds
NL8601354A (nl) * 1985-05-28 1986-12-16 Wellcome Found Nieuwe samenstelling.
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants

Also Published As

Publication number Publication date
GT198302091A (es) 1984-10-25
JPS5942321A (ja) 1984-03-08
JPS6291187A (ja) 1987-04-25
HU200615B (en) 1990-07-28
MX197183A (es) 1994-02-28
US5763253A (en) 1998-06-09
KR840004781A (ko) 1984-10-24
JPS6216931B2 (ja) 1987-04-15
SU1662352A3 (ru) 1991-07-07
JPH0134596B2 (ja) 1989-07-20

Similar Documents

Publication Publication Date Title
ZW10483A1 (en) Human tissue plasminogen activator
ZA833174B (en) Human tissue plasminogen activator
DE3377263D1 (en) Skin treatment composition
IL68193A0 (en) Dermatomes for cutting skin
GB2137932B (en) Absorbent tissue
GB8424685D0 (en) Absorbent surgical dressing
EP0112122A3 (en) Plasminogen activator
GB8414992D0 (en) Plasminogen activator
GB2121689B (en) Surgical sponge
HRP950158B1 (en) Human tissue plasminogen activator
AU563031C (en) Human Tissue Plasminogen Activator
GB8901422D0 (en) New tissue plasminogen activator
IE861388L (en) Tissue plasminogen activator
GB8726683D0 (en) Tissue plasminogen activator
GB8725052D0 (en) Tissue plasminogen activator
GB8718298D0 (en) Tissue plasminogen activator
GB8815245D0 (en) New tissue plasminogen activator
ZA862976B (en) Human tissue plasminogen activator mutants
IE870208L (en) Modified tissue plasminogen activator
GB9000629D0 (en) Tissue plasminogen activator
GB8826692D0 (en) Tissue plasminogen activator
GB8302019D0 (en) Human kallikrein
GB8815247D0 (en) New tissue plasminogen activator
GB8815246D0 (en) New tissue plasminogen activator
GB8302474D0 (en) Medical treatment