ZA828549B - 2-(4-(4,4-dialkyl-2,6-piperidinedion-1-yl)butyl)-1-piperazinyl)pyrimidines - Google Patents
2-(4-(4,4-dialkyl-2,6-piperidinedion-1-yl)butyl)-1-piperazinyl)pyrimidinesInfo
- Publication number
- ZA828549B ZA828549B ZA828549A ZA828549A ZA828549B ZA 828549 B ZA828549 B ZA 828549B ZA 828549 A ZA828549 A ZA 828549A ZA 828549 A ZA828549 A ZA 828549A ZA 828549 B ZA828549 B ZA 828549B
- Authority
- ZA
- South Africa
- Prior art keywords
- piperidinedion
- pyrimidines
- piperazinyl
- dialkyl
- butyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/334,688 US4423049A (en) | 1981-12-28 | 1981-12-28 | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA828549B true ZA828549B (en) | 1983-09-28 |
Family
ID=23308351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA828549A ZA828549B (en) | 1981-12-28 | 1982-11-19 | 2-(4-(4,4-dialkyl-2,6-piperidinedion-1-yl)butyl)-1-piperazinyl)pyrimidines |
Country Status (26)
Country | Link |
---|---|
US (1) | US4423049A (xx) |
JP (2) | JPS58118582A (xx) |
KR (1) | KR870001045B1 (xx) |
AT (1) | AT382373B (xx) |
AU (1) | AU555797B2 (xx) |
BE (1) | BE895504A (xx) |
CA (1) | CA1244426A (xx) |
CH (1) | CH656383A5 (xx) |
CY (1) | CY1379A (xx) |
DE (1) | DE3248160C2 (xx) |
DK (1) | DK162389C (xx) |
ES (2) | ES518510A0 (xx) |
FI (1) | FI70891C (xx) |
FR (1) | FR2518993B1 (xx) |
GB (1) | GB2114122B (xx) |
GR (1) | GR77045B (xx) |
HK (1) | HK5288A (xx) |
IE (1) | IE54619B1 (xx) |
IT (1) | IT1158039B (xx) |
KE (1) | KE3709A (xx) |
LU (1) | LU84561A1 (xx) |
NL (1) | NL193283C (xx) |
PT (1) | PT76036B (xx) |
SE (1) | SE453088B (xx) |
SG (1) | SG29787G (xx) |
ZA (1) | ZA828549B (xx) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4423049A (en) * | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
US4581357A (en) * | 1983-02-07 | 1986-04-08 | Mead Johnson & Company | Antipsychotic 5-fluoro-pyrimidin-2-yl piperazine compound |
US5187276A (en) * | 1983-06-18 | 1993-02-16 | Troponwerke Gmbh & Co. Kg. | 2-pyrimidinyl-1-piperazine derivatives |
DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
CA1250291A (en) * | 1984-07-23 | 1989-02-21 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)-piperazinyl derivatives of 1-pyrrolidin-2-ones |
NL8601494A (nl) * | 1985-06-22 | 1987-01-16 | Sandoz Ag | Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten. |
NZ216720A (en) * | 1985-07-08 | 1990-09-26 | Bristol Myers Co | Diazinylpiperidine derivatives and pharmaceutical compositions |
US4826843A (en) * | 1985-07-08 | 1989-05-02 | Bristol-Myers | Cerebral function enhancing diazinylpiperidine derivatives |
US4777254A (en) * | 1986-12-02 | 1988-10-11 | American Home Products Corp. | Cyclic imides as H1 -antagonists |
US4771053A (en) * | 1987-03-02 | 1988-09-13 | Bristol-Myers Company | Method for alleviation of primary depressive disorders |
US4782060A (en) * | 1987-07-29 | 1988-11-01 | Bristol-Myers Company | Gepirone for alleviation of panic disorders |
US4880930A (en) * | 1987-11-30 | 1989-11-14 | New James S | Psychotropic acyclic amide derivatives |
US5116970A (en) * | 1988-02-18 | 1992-05-26 | New James S | Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones |
US5001130A (en) * | 1988-02-18 | 1991-03-19 | Bristol-Myers Company | Psychotropic heterobicycloalkylpiperazine derivatives |
US4780466A (en) * | 1988-03-17 | 1988-10-25 | Hoechst-Roussel Pharmaceuticals, Inc. | Arylpiperazinylalkoxy derivatives of cyclic imides |
US5242911A (en) * | 1988-06-17 | 1993-09-07 | Pfizer Inc. | Bridged bicyclic imides as anxiolytics and antidepressants |
WO1990002552A1 (en) * | 1988-09-16 | 1990-03-22 | Pfizer Inc. | Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides |
FR2654934B1 (fr) * | 1989-11-29 | 1994-09-30 | Midy Spa | Utilisation de derive [4-(2-pyrimidinyl)-1-piperazinyl] butyliques pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale. |
US5098904A (en) * | 1990-06-27 | 1992-03-24 | Bristol-Myers Squibb Company | Cerebral function enhancing pyrimidinyl derivatives |
AU9164591A (en) * | 1990-12-14 | 1992-07-08 | New York University | Functional interactions between glial s-100b and central nervous system serotonergic neurons |
DE4135551A1 (de) * | 1991-08-31 | 1993-03-04 | Schering Ag | Verwendung von antagonisten oder partiellen agonisten am 5-ht1a-rezeptor zur behandlung und praevention von kognitiven stoerungen |
US5824680A (en) * | 1991-08-31 | 1998-10-20 | Bayer Aktiengesellschaft | Ipsapirone for the treatment of alzheimer's disease by improving memory |
GB9223153D0 (en) * | 1992-11-05 | 1992-12-16 | Wyeth John & Brother Ltd | Piperazine derivatives |
FR2701260B1 (fr) * | 1993-02-05 | 1995-05-05 | Esteve Labor Dr | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
US5338738A (en) * | 1993-04-19 | 1994-08-16 | Bristol-Myers Squibb Company | Cerebral function enhancers: acyclic amide derivatives of pyrimidinylpiperidines |
FR2705098B1 (fr) * | 1993-05-10 | 1995-08-04 | Esteve Labor Dr | Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) . |
US5538985A (en) * | 1994-01-27 | 1996-07-23 | Mitsui Toatsu Chemicals, Inc. | Pyrrolidinone derivatives |
US5521313A (en) * | 1994-05-05 | 1996-05-28 | Bristol-Myers Squibb Company | Process for preparing certain azapirones |
CA2146593A1 (en) * | 1994-05-05 | 1995-11-06 | Jack Melton | Large-scale process for azapirone synthesis |
US5478572A (en) * | 1994-09-06 | 1995-12-26 | Bristol-Myers Squibb Co. | Gepirone dosage form |
US6312717B1 (en) | 1998-07-07 | 2001-11-06 | Bristol-Myers Squibb Company | Method for treatment of anxiety and depression |
WO2000006163A1 (en) * | 1998-07-30 | 2000-02-10 | Bristol-Myers Squibb Company | Improved method for treatment of sleep-related respiratory disorders |
US6566361B2 (en) | 1999-06-30 | 2003-05-20 | Laboratories, Upsa | Azapirone pain treatment |
CN100367965C (zh) * | 1999-12-20 | 2008-02-13 | 法布瑞-克雷默制药有限公司 | 吉吡隆代谢物在制备改善哺乳动物不良心理状态的组合物上的应用 |
US6534507B1 (en) * | 1999-12-20 | 2003-03-18 | Fabre-Kramer Pharmaceuticals, Inc. | Methods for treating psychological disorders using bioactive metabolites of gepirone |
AU780817B2 (en) * | 2000-01-19 | 2005-04-21 | Akzo Nobel N.V. | Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone |
WO2002016347A1 (en) * | 2000-08-22 | 2002-02-28 | Akzo Nobel N.V. | Active metabolite of gepirone |
US6864262B2 (en) * | 2000-11-29 | 2005-03-08 | Eli Lilly And Company | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine and pharmaceutically acceptable salts and solvents thereof |
US20040002500A1 (en) * | 2002-06-28 | 2004-01-01 | Fabre Kramer Pharmaceutical, Inc. | Methods for treating attention deficit disorder |
US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
SG145701A1 (en) * | 2003-07-30 | 2008-09-29 | Xenon Pharmaceuticals Inc | Piperazine derivatives and their use as therapeutic agents |
ATE473967T1 (de) * | 2003-11-26 | 2010-07-15 | Pfizer Prod Inc | Aminopyrazolderivate als gsk-3-inhibitoren |
EP1809255A4 (en) * | 2004-11-05 | 2011-08-03 | Fabre Kramer Holdings Inc | HIGH DOSAGE FORMULATION OF GEPIRON WITH EXTENDED RELEASE |
US20060099267A1 (en) * | 2004-11-05 | 2006-05-11 | Fabre-Kramer Pharmaceuticals, Inc. | High-dosage extended-release formulation of gepirone |
PT2159226T (pt) * | 2007-03-29 | 2016-12-16 | Joint-Stock Company Obninsk Chemical Pharmaceutical Company | Agente anti-histamínico e antialérgico e um método para a produção do mesmo |
WO2011030139A1 (en) * | 2009-09-11 | 2011-03-17 | Astrazeneca Ab | 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators |
IT201900000657A1 (it) | 2019-01-16 | 2020-07-16 | Procos Spa | Processo per la sintesi di gepirone |
GB202014736D0 (en) * | 2020-09-18 | 2020-11-04 | Imperial College Innovations Ltd | Novel compounds and their use in therapy |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3398151A (en) * | 1966-02-01 | 1968-08-20 | Mead Johnson & Co | Azaspirodecanediones and azaspiroundecanediones |
BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
US3976776A (en) * | 1972-12-06 | 1976-08-24 | Mead Johnson & Company | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones |
US4182763A (en) * | 1978-05-22 | 1980-01-08 | Mead Johnson & Company | Buspirone anti-anxiety method |
DK251079A (da) | 1978-06-20 | 1979-12-21 | Synthelabo | Fremgangsmaade til fremstilling af phenylpiperazinderivater |
US4423049A (en) * | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
-
1981
- 1981-12-28 US US06/334,688 patent/US4423049A/en not_active Expired - Lifetime
-
1982
- 1982-11-19 ZA ZA828549A patent/ZA828549B/xx unknown
- 1982-11-22 CA CA000416088A patent/CA1244426A/en not_active Expired
- 1982-12-02 AU AU91083/82A patent/AU555797B2/en not_active Expired
- 1982-12-08 KR KR8205503A patent/KR870001045B1/ko active
- 1982-12-08 GR GR70021A patent/GR77045B/el unknown
- 1982-12-22 IT IT49719/82A patent/IT1158039B/it active
- 1982-12-23 GB GB08236593A patent/GB2114122B/en not_active Expired
- 1982-12-23 NL NL8204970A patent/NL193283C/nl not_active IP Right Cessation
- 1982-12-23 DK DK573182A patent/DK162389C/da not_active IP Right Cessation
- 1982-12-23 JP JP57225098A patent/JPS58118582A/ja active Granted
- 1982-12-23 ES ES518510A patent/ES518510A0/es active Granted
- 1982-12-23 FI FI824442A patent/FI70891C/fi not_active IP Right Cessation
- 1982-12-23 IE IE3067/82A patent/IE54619B1/en not_active IP Right Cessation
- 1982-12-23 CY CY137982A patent/CY1379A/xx unknown
- 1982-12-24 FR FR8221750A patent/FR2518993B1/fr not_active Expired
- 1982-12-27 SE SE8207425A patent/SE453088B/sv not_active IP Right Cessation
- 1982-12-27 PT PT76036A patent/PT76036B/pt unknown
- 1982-12-27 DE DE3248160A patent/DE3248160C2/de not_active Expired - Lifetime
- 1982-12-28 AT AT0469882A patent/AT382373B/de not_active IP Right Cessation
- 1982-12-28 BE BE0/209826A patent/BE895504A/fr not_active IP Right Cessation
- 1982-12-28 CH CH7594/82A patent/CH656383A5/de not_active IP Right Cessation
- 1982-12-29 LU LU84561A patent/LU84561A1/fr unknown
-
1983
- 1983-08-12 ES ES524945A patent/ES524945A0/es active Granted
-
1987
- 1987-03-27 SG SG297/87A patent/SG29787G/en unknown
- 1987-03-31 KE KE3709A patent/KE3709A/xx unknown
-
1988
- 1988-01-21 HK HK52/88A patent/HK5288A/xx not_active IP Right Cessation
-
1991
- 1991-03-29 JP JP3216768A patent/JPH06293753A/ja active Pending
Also Published As
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