ZA817675B - New nor-tropane and granatane derivatives,the process for preparing the same and their application in therapeutics - Google Patents
New nor-tropane and granatane derivatives,the process for preparing the same and their application in therapeuticsInfo
- Publication number
- ZA817675B ZA817675B ZA817675A ZA817675A ZA817675B ZA 817675 B ZA817675 B ZA 817675B ZA 817675 A ZA817675 A ZA 817675A ZA 817675 A ZA817675 A ZA 817675A ZA 817675 B ZA817675 B ZA 817675B
- Authority
- ZA
- South Africa
- Prior art keywords
- granatane
- tropane
- therapeutics
- derivatives
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8023785A FR2493848B2 (fr) | 1980-11-07 | 1980-11-07 | Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA817675B true ZA817675B (en) | 1982-10-27 |
Family
ID=9247763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA817675A ZA817675B (en) | 1980-11-07 | 1981-11-06 | New nor-tropane and granatane derivatives,the process for preparing the same and their application in therapeutics |
Country Status (15)
Country | Link |
---|---|
US (1) | US4434170A (no) |
JP (1) | JPS57108090A (no) |
BE (1) | BE890962R (no) |
CA (1) | CA1209574A (no) |
CH (1) | CH651561A5 (no) |
DE (1) | DE3144183A1 (no) |
ES (1) | ES8301979A2 (no) |
FR (1) | FR2493848B2 (no) |
GB (1) | GB2088364B (no) |
GR (1) | GR75112B (no) |
IT (1) | IT1140040B (no) |
LU (1) | LU83737A7 (no) |
NL (1) | NL8105042A (no) |
SE (1) | SE448457B (no) |
ZA (1) | ZA817675B (no) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2440946A2 (fr) * | 1978-01-20 | 1980-06-06 | Ile De France | Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement |
DE3268378D1 (en) * | 1981-06-17 | 1986-02-20 | Beecham Group Plc | Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions |
GB2111479A (en) * | 1981-10-01 | 1983-07-06 | Beecham Group Plc | Benzamides |
EP0083737A1 (en) * | 1981-12-15 | 1983-07-20 | Beecham Group Plc | N-azabicycloalkane benzamides, process for their preparation and pharmaceutical compositions containing them |
FI74707C (fi) * | 1982-06-29 | 1988-03-10 | Sandoz Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror. |
CA1244028A (en) * | 1983-04-14 | 1988-11-01 | Hans Maag | Pyrimidine derivatives |
FR2546169B1 (fr) * | 1983-05-20 | 1986-03-21 | Delalande Sa | N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique |
FR2548666A1 (fr) * | 1983-07-08 | 1985-01-11 | Delalande Sa | Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique |
DE3429830A1 (de) * | 1983-08-26 | 1985-03-07 | Sandoz-Patent-GmbH, 7850 Lörrach | Automatische carbonsaeure- und sulfonsaeureester oder -amide |
DE3445377A1 (de) * | 1983-12-23 | 1985-07-04 | Sandoz-Patent-GmbH, 7850 Lörrach | Carbocylische und heterocyclische carbonsaeureester und -amide von ueberbrueckten und nicht ueberbrueckten cyclischen stickstoffhaltigen aminen oder alkoholen |
ATE86110T1 (de) * | 1984-12-20 | 1993-03-15 | Sandoz Ag | Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten. |
EP0201165B1 (en) * | 1985-03-14 | 1994-07-20 | Beecham Group Plc | Medicaments for the treatment of emesis |
GB8516371D0 (en) * | 1985-06-28 | 1985-07-31 | Beecham Group Plc | Compounds |
HU895334D0 (en) * | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
GB9027098D0 (en) * | 1990-12-13 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
ATE169015T1 (de) * | 1992-02-04 | 1998-08-15 | Eisai Co Ltd | Aminobenzoesäure derivate |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
BRPI0507734A (pt) * | 2004-02-18 | 2007-07-10 | Astrazeneca Ab | composto ou um sal, pró-droga ou solvato do mesmo, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto |
WO2005080359A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
WO2006040527A1 (en) | 2004-10-16 | 2006-04-20 | Astrazeneca Ab | Process for making phenoxy benzamide compounds |
GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
US20110059941A1 (en) * | 2005-05-24 | 2011-03-10 | Peter William Rodney Caulkett | 2-phenyl substituted imidazol [4,5b] pyridine/pyrazine and purine derivatives as glucokinase modulators |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
EP1910350A1 (en) * | 2005-07-09 | 2008-04-16 | AstraZeneca AB | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes |
NZ575514A (en) * | 2005-07-09 | 2009-11-27 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
US20080234273A1 (en) * | 2005-07-09 | 2008-09-25 | Mckerrecher Darren | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes |
US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
CL2007003061A1 (es) * | 2006-10-26 | 2008-08-01 | Astrazeneca Ab | Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2. |
TW200833339A (en) * | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Novel crystalline compound |
WO2010015849A2 (en) * | 2008-08-04 | 2010-02-11 | Astrazeneca Ab | Therapeutic agents 414 |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
AR076220A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivados de pirazol [4,5 - e] pirimidina |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3134782A (en) | 1964-05-26 | Chjxch- | ||
GB774858A (en) | 1954-10-20 | 1957-05-15 | Sandoz Ltd | Tropane and -Î-tropane derivatives and process for preparation thereof |
FR1162129A (fr) * | 1954-10-20 | 1958-09-09 | Sandoz Ag | Dérivés amidés du tropane et leur préparation |
CH374679A (de) | 1958-11-26 | 1964-01-31 | Sandoz Ag | Verfahren zur Herstellung von neuen Tropan-Derivaten |
US4179567A (en) | 1978-04-10 | 1979-12-18 | Sterling Drug Inc. | 2-Aryltropane compounds |
JPS5592384A (en) * | 1978-12-30 | 1980-07-12 | Beecham Group Ltd | Compound having pharmacological activity |
IL59004A0 (en) | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
FR2446823A1 (fr) * | 1979-01-16 | 1980-08-14 | Delalande Sa | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
FR2476088A2 (fr) * | 1979-01-16 | 1981-08-21 | Delalande Sa | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
-
1980
- 1980-11-07 FR FR8023785A patent/FR2493848B2/fr not_active Expired
-
1981
- 1981-10-23 CH CH6772/81A patent/CH651561A5/fr not_active IP Right Cessation
- 1981-10-29 GR GR66378A patent/GR75112B/el unknown
- 1981-10-30 SE SE8106425A patent/SE448457B/sv not_active IP Right Cessation
- 1981-11-03 BE BE0/206420A patent/BE890962R/fr not_active IP Right Cessation
- 1981-11-03 IT IT24835/81A patent/IT1140040B/it active
- 1981-11-04 US US06/318,244 patent/US4434170A/en not_active Expired - Lifetime
- 1981-11-04 GB GB8133254A patent/GB2088364B/en not_active Expired
- 1981-11-05 CA CA000389504A patent/CA1209574A/en not_active Expired
- 1981-11-05 LU LU83737A patent/LU83737A7/fr unknown
- 1981-11-05 ES ES507394A patent/ES8301979A2/es not_active Expired
- 1981-11-06 DE DE19813144183 patent/DE3144183A1/de active Granted
- 1981-11-06 ZA ZA817675A patent/ZA817675B/xx unknown
- 1981-11-07 JP JP56178920A patent/JPS57108090A/ja active Granted
- 1981-11-07 NL NL8105042A patent/NL8105042A/nl not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US4434170A (en) | 1984-02-28 |
CH651561A5 (fr) | 1985-09-30 |
IT8124835A0 (it) | 1981-11-03 |
NL8105042A (nl) | 1982-06-01 |
SE448457B (sv) | 1987-02-23 |
DE3144183A1 (de) | 1982-08-12 |
GB2088364B (en) | 1984-10-31 |
GB2088364A (en) | 1982-06-09 |
IT1140040B (it) | 1986-09-24 |
JPS6344753B2 (no) | 1988-09-06 |
GR75112B (no) | 1984-07-13 |
JPS57108090A (en) | 1982-07-05 |
BE890962R (fr) | 1982-05-03 |
DE3144183C2 (no) | 1992-01-23 |
CA1209574A (en) | 1986-08-12 |
SE8106425L (sv) | 1982-05-08 |
LU83737A7 (fr) | 1983-09-01 |
FR2493848B2 (fr) | 1986-05-16 |
ES507394A0 (es) | 1983-02-01 |
ES8301979A2 (es) | 1983-02-01 |
FR2493848A2 (fr) | 1982-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA817675B (en) | New nor-tropane and granatane derivatives,the process for preparing the same and their application in therapeutics | |
ZA834704B (en) | New 3-amino quinuclidine derivatives,the process for preparing same and the application thereof in therapeutics | |
ZA801081B (en) | Polyol derivatives,processes for preparing the same and their uses in therapeutics | |
ZA831134B (en) | New derivatives of piperazine,the method of preparing same and their application in therapeutics | |
IL73159A0 (en) | Carboxyalkenamidocephalosporines,process for the preparation thereof and methods for the use thereof | |
DE3171273D1 (en) | Immunoparticles and process for preparing the same | |
EP0029912A3 (en) | Mould-half, in particular laminating mould-half, and process for making it | |
PH17705A (en) | Triazoline derivatives,process for producing the same and use thereof | |
EG15890A (en) | Pyridoxine derivatives,process for preparing them and use in therapeutics | |
DE3262455D1 (en) | Diphenoxypropane derivatives, their production and use | |
ZA813567B (en) | Novel n-aryl azolone derivatives,the process for preparing the same and their application in therapeutics | |
DE3071484D1 (en) | Linear polychlorophosphazenes, process for their preparation and their use | |
DE3061468D1 (en) | 6-deoxyglucosamine-peptide derivatives, their production and use | |
DE3065163D1 (en) | New 4-fluoro-3-phenoxy-benzyl-ethers, process for their preparation and their use | |
GB2053196B (en) | Derivatives of 5h-furanone-2 and of 3h-dihydrofuranone-2,the process for preparing the same and their application in therapeutics | |
GB2087586B (en) | Sec-butylbiphenyl composition and process for preparing the same | |
YU215484A (en) | Process for preparing glyoxale, alkylglyoxales and their acethales | |
DE3162203D1 (en) | Isoindoline derivatives, process for their preparation and their use | |
DE3463041D1 (en) | Tributylphenolether-glycidyl-sulphonates, process for their preparation and their use | |
ZA802673B (en) | Novel derivatives of 5h-furanone-2 and of 3h-dihydrofuranone-2, the process for preparing the same and their application in therapeutics | |
IL51877A (en) | -nor-16-benzyl or phenoxy-13,14-dehydro-prostaglandins and process for their preparation | |
DE3168442D1 (en) | Tetrazolylcoumarin derivatives, process for preparing the same and composition containing the same | |
EP0033611A3 (en) | N-benzylphenylacetamide derivatives, their production and use | |
ZA80160B (en) | Novel nor-tropane derivatives,a process for preparing same and their application in therapeutics | |
DE3264284D1 (en) | Bisimidazolines, process for their preparation and their use |