ZA796651B - New amino-pyrimidine-carbanilides, processes for their preparation, medicaments containing these compounds and their use and also diamino-pyrimidinecarbanilides and processes for their preparation - Google Patents
New amino-pyrimidine-carbanilides, processes for their preparation, medicaments containing these compounds and their use and also diamino-pyrimidinecarbanilides and processes for their preparationInfo
- Publication number
- ZA796651B ZA796651B ZA00796651A ZA796651A ZA796651B ZA 796651 B ZA796651 B ZA 796651B ZA 00796651 A ZA00796651 A ZA 00796651A ZA 796651 A ZA796651 A ZA 796651A ZA 796651 B ZA796651 B ZA 796651B
- Authority
- ZA
- South Africa
- Prior art keywords
- processes
- preparation
- compounds
- pyrimidine
- pyrimidinecarbanilides
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- UHTQCIIJINIRDT-UHFFFAOYSA-N 4-amino-n-phenylpyrimidine-2-carboxamide Chemical class NC1=CC=NC(C(=O)NC=2C=CC=CC=2)=N1 UHTQCIIJINIRDT-UHFFFAOYSA-N 0.000 title 1
- -1 diamino-pyrimidinecarbanilides Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- 229940051881 anilide analgesics and antipyretics Drugs 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782853220 DE2853220A1 (de) | 1978-12-09 | 1978-12-09 | Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA796651B true ZA796651B (en) | 1981-05-27 |
Family
ID=6056720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00796651A ZA796651B (en) | 1978-12-09 | 1979-12-07 | New amino-pyrimidine-carbanilides, processes for their preparation, medicaments containing these compounds and their use and also diamino-pyrimidinecarbanilides and processes for their preparation |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4285946A (enExample) |
| EP (1) | EP0012361B1 (enExample) |
| JP (1) | JPS5581863A (enExample) |
| AT (1) | ATE1288T1 (enExample) |
| AU (1) | AU529426B2 (enExample) |
| CA (1) | CA1136623A (enExample) |
| DE (2) | DE2853220A1 (enExample) |
| ES (3) | ES8102121A1 (enExample) |
| ZA (1) | ZA796651B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4436911A (en) * | 1981-05-12 | 1984-03-13 | William H. Rorer, Inc. | Heterocyclic amidinoureas |
| JPS58501468A (ja) * | 1981-08-24 | 1983-09-01 | ロウラ− インタ−ナシヨナル （オ−バ−シ−ズ） インコ−ポレ−テツド | 複素環アミジノ置換尿素およびそれらの薬剤利用 |
| DE3522940A1 (de) * | 1985-06-27 | 1987-01-08 | Hoechst Ag | 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln |
| ES2098570T3 (es) * | 1992-02-22 | 1997-05-01 | Hoechst Ag | Amidas de un acido 4-amino-2-ureido-pirimidina-5-carboxilico, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su utilizacion. |
| ATE158581T1 (de) * | 1992-02-22 | 1997-10-15 | Hoechst Ag | Lösliche salze von 4-amino-2-(4,4-dimethyl- imidazolidin-2-on-1-yl)-pyrimidin-5 -carbonsäure- n-methyl-n-(3-trifluormethyl-phenyl)- amid, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und ausgangsprodukte |
| DE19625088A1 (de) * | 1996-06-24 | 1998-01-02 | Hoechst Ag | 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19625089A1 (de) * | 1996-06-24 | 1998-01-02 | Hoechst Ag | 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| ATE314362T1 (de) * | 1999-10-12 | 2006-01-15 | Takeda Pharmaceutical | Pyrimidin-5-carboximidverbindungen, verfahren zur herstellung derselben und deren verwendung |
| US7176310B1 (en) * | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
| US8193206B2 (en) * | 2005-06-14 | 2012-06-05 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
| EA015890B1 (ru) * | 2005-06-14 | 2011-12-30 | Тайджен Байотекнолоджи Ко. Лтд. | Производные пиримидина |
| AU2009225869B2 (en) | 2008-03-18 | 2014-01-23 | Merck Sharp & Dohme Llc | Substituted 4-hydroxypyrimidine-5-carboxamides |
| JP5317263B2 (ja) * | 2008-09-24 | 2013-10-16 | 株式会社ユニバーサルエンターテインメント | 紙葉類処理装置 |
| CN104125947A (zh) * | 2011-12-21 | 2014-10-29 | 生物区欧洲有限公司 | 杂环脲化合物 |
| WO2016161268A1 (en) | 2015-04-01 | 2016-10-06 | Enanta Pharmaceuticals, Inc. | Hepatitis b antviral agents |
| US10738035B2 (en) * | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| KR102398439B1 (ko) | 2016-03-07 | 2022-05-16 | 이난타 파마슈티칼스, 인코포레이티드 | B형 간염 항바이러스제 |
| EP3468561A4 (en) | 2016-06-10 | 2019-12-04 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| SG11202001685TA (en) | 2017-08-28 | 2020-03-30 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| US10723733B2 (en) | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2019113173A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US10729688B2 (en) | 2018-03-29 | 2020-08-04 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| TW202024093A (zh) | 2018-09-21 | 2020-07-01 | 美商安塔製藥公司 | 作為抗病毒劑之官能化雜環 |
| EP3883570A4 (en) | 2018-11-21 | 2022-07-13 | Enanta Pharmaceuticals, Inc. | FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1031265A (en) * | 1963-11-12 | 1966-06-02 | Geigy Co Ltd | Tri-tertiary aminopyrimidines and their production |
| US3479357A (en) * | 1967-10-20 | 1969-11-18 | Searle & Co | (6 - phenylpyrimidine)mono/bis(1h - 1,2,3-triazole- 4,5-dicarboxylic acid) lower alkyl esters |
-
1978
- 1978-12-09 DE DE19782853220 patent/DE2853220A1/de not_active Withdrawn
-
1979
- 1979-12-03 ES ES486536A patent/ES8102121A1/es not_active Expired
- 1979-12-05 AT AT79104950T patent/ATE1288T1/de active
- 1979-12-05 EP EP79104950A patent/EP0012361B1/de not_active Expired
- 1979-12-05 DE DE7979104950T patent/DE2963278D1/de not_active Expired
- 1979-12-07 US US06/101,160 patent/US4285946A/en not_active Expired - Lifetime
- 1979-12-07 CA CA000341493A patent/CA1136623A/en not_active Expired
- 1979-12-07 AU AU53571/79A patent/AU529426B2/en not_active Ceased
- 1979-12-07 ZA ZA00796651A patent/ZA796651B/xx unknown
- 1979-12-07 JP JP15827579A patent/JPS5581863A/ja active Granted
-
1980
- 1980-05-07 ES ES491225A patent/ES8101069A1/es not_active Expired
- 1980-05-07 ES ES491224A patent/ES491224A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ES8101068A1 (es) | 1980-12-01 |
| ES491224A0 (es) | 1980-12-01 |
| JPS5581863A (en) | 1980-06-20 |
| US4285946A (en) | 1981-08-25 |
| JPH0457675B2 (enExample) | 1992-09-14 |
| EP0012361A1 (de) | 1980-06-25 |
| EP0012361B1 (de) | 1982-06-30 |
| ES491225A0 (es) | 1980-12-01 |
| CA1136623A (en) | 1982-11-30 |
| ATE1288T1 (de) | 1982-07-15 |
| ES486536A0 (es) | 1980-12-16 |
| DE2963278D1 (en) | 1982-08-19 |
| DE2853220A1 (de) | 1980-07-03 |
| AU5357179A (en) | 1980-06-12 |
| ES8101069A1 (es) | 1980-12-01 |
| ES8102121A1 (es) | 1980-12-16 |
| AU529426B2 (en) | 1983-06-09 |
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