ES8102121A1 - Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico - Google Patents

Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico

Info

Publication number
ES8102121A1
ES8102121A1 ES486536A ES486536A ES8102121A1 ES 8102121 A1 ES8102121 A1 ES 8102121A1 ES 486536 A ES486536 A ES 486536A ES 486536 A ES486536 A ES 486536A ES 8102121 A1 ES8102121 A1 ES 8102121A1
Authority
ES
Spain
Prior art keywords
pyrimidine
amino
carbanilides
preparation
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES486536A
Other languages
English (en)
Other versions
ES486536A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES486536A0 publication Critical patent/ES486536A0/es
Publication of ES8102121A1 publication Critical patent/ES8102121A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE ANILIDAS DE ACIDOS 4-AMINO-2-AUREIDO-PIRIMIDIN-5-CARBOXILICOS Y DE SUS SALES. ESTOS COMPUESTOS TIENEN LA SIGUIENTE FORMULA GENERAL (I), DONDE R ELEVADO A 1, R ELEVADO A 4 Y R ELEVADO A 5 SON HIDROGENO; R ELEVADO A 6 Y R ELEVADO A 7 SON HIDROGENO, UN GRUPO ALCOHILO, UN GRUPO ALQUENILO, ETC.; R ELEVADO A 2 Y R ELEVADO A 3 SON UN RADICAL ALCOHILO O UN RADICAL FENILO, Y R ELEVADO A 8 ES FLUOR, CLORO, BROMO, METILO, ALCOXI O TRIFLUOROMETILO. EL PROCEDIMIENTO DE OBTENCION SE FUNDAMENTA EN LA REACCION DE COMPUESTOS DE FORMULA (II), DONDE R ELEVADOA 11 ES HIDROGENO, UN GRUPO ALCOHILO O FENILO, Y R ELEVADO A 12 Y R ELEVADO A 13 SON HIDROGENO, UN GRUPO ALCOHILO O SUS SALES POR ADICION DE ACIDOS; CON UN COMPUESTO DE FORMULA (III): DICHA REACCION PUEDE REALIZARSE EN PRESENCIA O AUSENCIA DE DISOLVENTE, O DE AGENTE DILUYENTE. LOS COMPUESTOS OBTENIDOS SON DE ESPECIAL INTERES EN EL TRATAMIENTO DE PERTURBACIONES DEL METABOLISMO DE LIPIDOS Y EN EL DE LA ADIPOSIDAD. *FORMULA*
ES486536A 1978-12-09 1979-12-03 Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico Expired ES8102121A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782853220 DE2853220A1 (de) 1978-12-09 1978-12-09 Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung

Publications (2)

Publication Number Publication Date
ES486536A0 ES486536A0 (es) 1980-12-16
ES8102121A1 true ES8102121A1 (es) 1980-12-16

Family

ID=6056720

Family Applications (3)

Application Number Title Priority Date Filing Date
ES486536A Expired ES8102121A1 (es) 1978-12-09 1979-12-03 Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico
ES491224A Granted ES491224A0 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de anilidas de acidos 4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilicos
ES491225A Expired ES8101069A1 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de 2,4-diamino-pirimidin-5-carbanilidas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES491224A Granted ES491224A0 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de anilidas de acidos 4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilicos
ES491225A Expired ES8101069A1 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de 2,4-diamino-pirimidin-5-carbanilidas

Country Status (9)

Country Link
US (1) US4285946A (es)
EP (1) EP0012361B1 (es)
JP (1) JPS5581863A (es)
AT (1) ATE1288T1 (es)
AU (1) AU529426B2 (es)
CA (1) CA1136623A (es)
DE (2) DE2853220A1 (es)
ES (3) ES8102121A1 (es)
ZA (1) ZA796651B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4436911A (en) * 1981-05-12 1984-03-13 William H. Rorer, Inc. Heterocyclic amidinoureas
GB2115419B (en) * 1981-08-24 1985-10-02 Rorer International Heterocyclic amidino substituted ureas and their pharmaceutical uses
DE3522940A1 (de) * 1985-06-27 1987-01-08 Hoechst Ag 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln
DE59307402D1 (de) * 1992-02-22 1997-10-30 Hoechst Ag Lösliche Salze von 4-Amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5 -carbonsäure- N-methyl-N-(3-trifluormethyl-phenyl)- amid, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel und Ausgangsprodukte
ES2098570T3 (es) * 1992-02-22 1997-05-01 Hoechst Ag Amidas de un acido 4-amino-2-ureido-pirimidina-5-carboxilico, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su utilizacion.
DE19625088A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19625089A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
AU7683500A (en) 1999-10-12 2001-04-23 Takeda Chemical Industries Ltd. Pyrimidine-5-carboxamide compounds, process for producing the same and use thereof
US7176310B1 (en) * 2002-04-09 2007-02-13 Ucb Sa Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
US8193206B2 (en) * 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
EP1890703B1 (en) * 2005-06-14 2016-05-11 Taigen Biotechnology Pyrimidine compounds as chemokine receptors inhibitors
WO2009117269A1 (en) 2008-03-18 2009-09-24 Merck & Co., Inc. Substituted 4-hydroxypyrimidine-5-carboxamides
JP5317263B2 (ja) * 2008-09-24 2013-10-16 株式会社ユニバーサルエンターテインメント 紙葉類処理装置
CN104125947A (zh) * 2011-12-21 2014-10-29 生物区欧洲有限公司 杂环脲化合物
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10738035B2 (en) * 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10179131B2 (en) 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
EP3426245B1 (en) 2016-03-07 2022-12-14 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
AU2017277664A1 (en) 2016-06-10 2019-01-24 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10952978B2 (en) 2017-08-28 2021-03-23 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
TW201936192A (zh) 2017-12-06 2019-09-16 美商因那塔製藥公司 B 型肝炎抗病毒試劑
TW201927789A (zh) 2017-12-06 2019-07-16 美商因那塔製藥公司 B型肝炎抗病毒試劑
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2019191166A1 (en) 2018-03-29 2019-10-03 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
KR20210065965A (ko) 2018-09-21 2021-06-04 이난타 파마슈티칼스, 인코포레이티드 항바이러스제로서 작용화된 헤테로사이클
EP3883570A4 (en) 2018-11-21 2022-07-13 Enanta Pharmaceuticals, Inc. FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
US11760755B2 (en) 2019-06-04 2023-09-19 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031265A (en) * 1963-11-12 1966-06-02 Geigy Co Ltd Tri-tertiary aminopyrimidines and their production
US3479357A (en) * 1967-10-20 1969-11-18 Searle & Co (6 - phenylpyrimidine)mono/bis(1h - 1,2,3-triazole- 4,5-dicarboxylic acid) lower alkyl esters

Also Published As

Publication number Publication date
ES486536A0 (es) 1980-12-16
AU529426B2 (en) 1983-06-09
ES8101068A1 (es) 1980-12-01
ES491225A0 (es) 1980-12-01
AU5357179A (en) 1980-06-12
ES491224A0 (es) 1980-12-01
ATE1288T1 (de) 1982-07-15
EP0012361A1 (de) 1980-06-25
ES8101069A1 (es) 1980-12-01
US4285946A (en) 1981-08-25
JPH0457675B2 (es) 1992-09-14
EP0012361B1 (de) 1982-06-30
ZA796651B (en) 1981-05-27
DE2963278D1 (en) 1982-08-19
DE2853220A1 (de) 1980-07-03
CA1136623A (en) 1982-11-30
JPS5581863A (en) 1980-06-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301