ZA794923B - New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents - Google Patents
New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agentsInfo
- Publication number
- ZA794923B ZA794923B ZA00794923A ZA794923A ZA794923B ZA 794923 B ZA794923 B ZA 794923B ZA 00794923 A ZA00794923 A ZA 00794923A ZA 794923 A ZA794923 A ZA 794923A ZA 794923 B ZA794923 B ZA 794923B
- Authority
- ZA
- South Africa
- Prior art keywords
- formula
- lower alkyl
- new
- hydrogen
- pyrrolyl
- Prior art date
Links
- 229940030600 antihypertensive agent Drugs 0.000 title abstract 2
- 239000002220 antihypertensive agent Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
- FNDJBMQTFVHDPR-UHFFFAOYSA-N 1-[4-[(2,5-dimethylpyrrol-1-yl)amino]phthalazin-1-yl]piperidin-4-ol Chemical compound CC1=CC=C(C)N1NC(C1=CC=CC=C11)=NN=C1N1CCC(O)CC1 FNDJBMQTFVHDPR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 dicarbonyl compound Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- PXYUEEJAXOCGBZ-UHFFFAOYSA-N n-(1h-pyrrol-2-yl)pyridazin-3-amine Chemical class C=1C=CN=NC=1NC1=CC=CN1 PXYUEEJAXOCGBZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7838898 | 1978-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA794923B true ZA794923B (en) | 1980-09-24 |
Family
ID=10500040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00794923A ZA794923B (en) | 1978-10-02 | 1979-09-17 | New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0009655B1 (en, 2012) |
| JP (1) | JPS5569577A (en, 2012) |
| AT (1) | ATE3294T1 (en, 2012) |
| AU (1) | AU529482B2 (en, 2012) |
| CA (1) | CA1144165A (en, 2012) |
| DE (1) | DE2965377D1 (en, 2012) |
| DK (1) | DK151803C (en, 2012) |
| ES (1) | ES484616A1 (en, 2012) |
| FI (1) | FI65998C (en, 2012) |
| GR (1) | GR69856B (en, 2012) |
| IE (1) | IE49017B1 (en, 2012) |
| IL (1) | IL58256A (en, 2012) |
| NO (1) | NO151620C (en, 2012) |
| YU (1) | YU41886B (en, 2012) |
| ZA (1) | ZA794923B (en, 2012) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1150070B (it) * | 1980-12-22 | 1986-12-10 | Lepetit Spa | Procedimento per preparare derivati n-pirrolipiridazinamminici |
| US5254622A (en) * | 1988-12-09 | 1993-10-19 | Asahi Kasei Kogyo Kabushiki Kaisha | ABS resin compositions and molded articles thereof having improved coating performances |
| JP4831577B2 (ja) * | 2003-07-30 | 2011-12-07 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ピリダジン誘導体および治療剤としての用途 |
| AU2005286731A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| JP5094398B2 (ja) | 2004-09-20 | 2012-12-12 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環式誘導体およびステアロイル−ＣｏＡデサチュラーゼのメディエータとしてのそれらの使用 |
| EP1804799B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| AU2005286793A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
| AR051202A1 (es) | 2004-09-20 | 2006-12-27 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| AR051092A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| USD916552S1 (en) * | 2019-07-26 | 2021-04-20 | Spectrum Diversified Designs, Llc | Trivet |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1168334A (en) * | 1967-01-25 | 1969-10-22 | Lepetit Spa | New Pharmacologically Active Pyridazines |
| GB1378102A (en) * | 1972-03-14 | 1974-12-18 | Lepetit Spa | Antihypertensive compositions |
| GB1408362A (en) * | 1973-05-25 | 1975-10-01 | Lepetit Spa | 2-pyrrol-1-yl amino 4,5-dihydro-1-h-imidazole derivatives |
| AU477837B2 (en) * | 1973-05-30 | 1974-12-05 | I. S. F. Sp. A | New anti-hypertensive compounds having a high therapeutic index and a long-term hypotensive effect |
| ES431009A1 (es) * | 1974-05-09 | 1976-10-16 | Isf Spa | Procedimiento para la preparacion de derivados de 3-benci- lidenhidracino-6-aminopiridacina. |
-
1979
- 1979-09-07 AT AT79103326T patent/ATE3294T1/de active
- 1979-09-07 DE DE7979103326T patent/DE2965377D1/de not_active Expired
- 1979-09-07 EP EP79103326A patent/EP0009655B1/en not_active Expired
- 1979-09-12 FI FI792832A patent/FI65998C/fi not_active IP Right Cessation
- 1979-09-14 AU AU50866/79A patent/AU529482B2/en not_active Ceased
- 1979-09-17 IL IL58256A patent/IL58256A/xx unknown
- 1979-09-17 ZA ZA00794923A patent/ZA794923B/xx unknown
- 1979-09-24 GR GR60097A patent/GR69856B/el unknown
- 1979-09-25 DK DK400679A patent/DK151803C/da not_active IP Right Cessation
- 1979-09-28 YU YU2374/79A patent/YU41886B/xx unknown
- 1979-10-01 NO NO793151A patent/NO151620C/no unknown
- 1979-10-01 IE IE1866/79A patent/IE49017B1/en not_active IP Right Cessation
- 1979-10-01 ES ES484616A patent/ES484616A1/es not_active Expired
- 1979-10-02 CA CA000336843A patent/CA1144165A/en not_active Expired
- 1979-10-02 JP JP12647779A patent/JPS5569577A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ES484616A1 (es) | 1980-05-16 |
| DK400679A (da) | 1980-04-03 |
| DE2965377D1 (en) | 1983-06-16 |
| IE49017B1 (en) | 1985-07-10 |
| FI792832A7 (fi) | 1980-04-03 |
| EP0009655A1 (en) | 1980-04-16 |
| GR69856B (en, 2012) | 1982-07-19 |
| CA1144165A (en) | 1983-04-05 |
| IL58256A (en) | 1984-02-29 |
| NO793151L (no) | 1980-04-08 |
| ATE3294T1 (de) | 1983-05-15 |
| FI65998B (fi) | 1984-04-30 |
| AU5086679A (en) | 1980-04-17 |
| FI65998C (fi) | 1984-08-10 |
| NO151620C (no) | 1985-05-08 |
| DK151803C (da) | 1988-06-13 |
| IL58256A0 (en) | 1979-12-30 |
| EP0009655B1 (en) | 1983-05-11 |
| IE791866L (en) | 1980-04-02 |
| JPS5569577A (en) | 1980-05-26 |
| JPH0321553B2 (en, 2012) | 1991-03-22 |
| YU237479A (en) | 1983-02-28 |
| NO151620B (no) | 1985-01-28 |
| AU529482B2 (en) | 1983-06-09 |
| DK151803B (da) | 1988-01-04 |
| YU41886B (en) | 1988-02-29 |
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