ZA755699B - Tetracyclic compounds and processes for their preparation - Google Patents

Tetracyclic compounds and processes for their preparation

Info

Publication number
ZA755699B
ZA755699B ZA00755699A ZA755699A ZA755699B ZA 755699 B ZA755699 B ZA 755699B ZA 00755699 A ZA00755699 A ZA 00755699A ZA 755699 A ZA755699 A ZA 755699A ZA 755699 B ZA755699 B ZA 755699B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
tetracyclic compounds
tetracyclic
compounds
Prior art date
Application number
ZA00755699A
Other languages
English (en)
Inventor
H Wahlig
J Gante
R Steinigeweg
R Bergmann
J Seubert
R Gottschlich
W Rogalski
R Kirchlechner
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA755699B publication Critical patent/ZA755699B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/18Ring systems of four or more rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06Benzothiopyrans; Hydrogenated benzothiopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
ZA00755699A 1974-09-06 1975-09-05 Tetracyclic compounds and processes for their preparation ZA755699B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2442829A DE2442829A1 (de) 1974-09-06 1974-09-06 Tetracyclische verbindungen und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ZA755699B true ZA755699B (en) 1976-08-25

Family

ID=5925100

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00755699A ZA755699B (en) 1974-09-06 1975-09-05 Tetracyclic compounds and processes for their preparation

Country Status (21)

Country Link
US (1) US4024272A (cs)
JP (1) JPS5154564A (cs)
AT (1) AT344890B (cs)
BE (1) BE833048A (cs)
CA (1) CA1068285A (cs)
CS (1) CS191275B2 (cs)
DD (1) DD121637A5 (cs)
DE (1) DE2442829A1 (cs)
DK (1) DK397875A (cs)
ES (1) ES440765A1 (cs)
FR (1) FR2283690A1 (cs)
GB (1) GB1467206A (cs)
HU (2) HU173491B (cs)
IE (1) IE41675B1 (cs)
IL (1) IL48044A (cs)
IT (1) IT7948216A0 (cs)
LU (1) LU73332A1 (cs)
NL (1) NL7510505A (cs)
PL (1) PL96677B1 (cs)
SE (1) SE7509880L (cs)
ZA (1) ZA755699B (cs)

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US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
EP0416564A3 (en) * 1989-09-05 1992-03-11 Kao Corporation Novel aroyl ketone derivative, uv ray absorber comprising the same, and cosmetic composition containing the same
US6756365B2 (en) 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
FR2795722A1 (fr) * 1999-07-02 2001-01-05 Rhodia Chimie Sa Procede de preparation d'une arylhydrazine hydroxylee, produits intermediaires et leur procede d'obtention
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
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US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
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JP4963771B2 (ja) 2000-07-07 2012-06-27 トラスティーズ・オブ・タフツ・カレッジ 7、8および9−置換テトラサイクリン化合物
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
CZ303702B6 (cs) 2000-07-07 2013-03-20 Trustees Of Tufts College Minocyklinové slouceniny
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US6818635B2 (en) 2000-07-07 2004-11-16 Paratek Pharmaceuticals, Inc. 7-substituted tetracycline compounds
EP2204361B1 (en) 2000-07-07 2011-09-28 Trustees Of Tufts College 13-substituted methacycline compounds
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EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
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US6730697B2 (en) * 2002-02-07 2004-05-04 Aventis Pharma Deutschland Gmbh Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid
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WO2004038001A2 (en) 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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CA2553510C (en) * 2004-01-15 2012-09-25 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
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EP1805134B1 (en) * 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437487A1 (de) * 1974-08-03 1976-02-19 Merck Patent Gmbh 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
IE41675L (en) 1976-03-06
BE833048A (nl) 1976-03-03
NL7510505A (nl) 1976-03-09
IE41675B1 (en) 1980-02-27
CS191275B2 (en) 1979-06-29
ES440765A1 (es) 1977-06-16
GB1467206A (en) 1977-03-16
IL48044A0 (en) 1975-11-25
DK397875A (da) 1976-03-07
JPS5154564A (cs) 1976-05-13
IT7948216A0 (it) 1979-03-05
US4024272A (en) 1977-05-17
DE2442829A1 (de) 1976-03-18
SE7509880L (sv) 1976-03-08
HU176136B (en) 1980-12-28
LU73332A1 (cs) 1976-04-13
CA1068285A (en) 1979-12-18
HU173491B (hu) 1979-05-28
AU8459975A (en) 1977-03-10
PL96677B1 (pl) 1978-01-31
AT344890B (de) 1978-08-10
DD121637A5 (cs) 1976-08-12
FR2283690A1 (fr) 1976-04-02
ATA689275A (de) 1977-12-15
FR2283690B1 (cs) 1980-03-28
IL48044A (en) 1978-12-17

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