ZA733218B - Compounds of the pregnene series having anaesthetic activity - Google Patents

Compounds of the pregnene series having anaesthetic activity

Info

Publication number
ZA733218B
ZA733218B ZA733218A ZA733218A ZA733218B ZA 733218 B ZA733218 B ZA 733218B ZA 733218 A ZA733218 A ZA 733218A ZA 733218 A ZA733218 A ZA 733218A ZA 733218 B ZA733218 B ZA 733218B
Authority
ZA
South Africa
Prior art keywords
compounds
anaesthetic activity
pregnene series
pregnene
series
Prior art date
Application number
ZA733218A
Other languages
English (en)
Inventor
G Phillipps
R Lawrence
L Stephenson
B Ayres
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of ZA733218B publication Critical patent/ZA733218B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA733218A 1972-05-12 1973-05-11 Compounds of the pregnene series having anaesthetic activity ZA733218B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2248972A GB1436324A (en) 1972-05-12 1972-05-12 Anaesthetic 3alpha-hydroxy pregnanes

Publications (1)

Publication Number Publication Date
ZA733218B true ZA733218B (en) 1974-05-29

Family

ID=10180241

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA733218A ZA733218B (en) 1972-05-12 1973-05-11 Compounds of the pregnene series having anaesthetic activity

Country Status (13)

Country Link
US (1) US3998829A (de)
JP (1) JPS4948652A (de)
AU (1) AU474687B2 (de)
BE (1) BE799433A (de)
CA (1) CA1014947A (de)
DE (1) DE2323950A1 (de)
DK (1) DK135775B (de)
FR (1) FR2184711B1 (de)
GB (1) GB1436324A (de)
IE (1) IE38863B1 (de)
LU (1) LU67585A1 (de)
NL (1) NL7306606A (de)
ZA (1) ZA733218B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613463A (en) * 1984-11-01 1986-09-23 The Upjohn Company Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid
USRE35053E (en) * 1985-09-12 1995-10-10 The Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5506354A (en) * 1985-09-12 1996-04-09 The Upjohn Company Imidazolylpiperazinyl steroids
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
JPH072555Y2 (ja) * 1991-06-03 1995-01-25 日野自動車工業株式会社 車輛の前後方向兼用ウインチ
US6780853B1 (en) 1995-06-06 2004-08-24 Euro-Celtique S.A. Neuroactive steroids of the androstane and pregnane series
DE69634039T2 (de) * 1995-06-06 2005-12-08 Euro-Celtique S.A. Steroidderivate der Androstan- und der Pregnanreihe
US6143737A (en) * 1995-06-23 2000-11-07 Georgetown University Progesterone analogs to reverse multidrug resistance
CA2372342A1 (en) * 1999-04-29 2000-11-09 Derk J. Hogenkamp 3.alpha.-hydroxy-3.beta. methoxymethyl-21-heterocycle substituted steroids with anesthetic activity
US20050101581A1 (en) * 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
EP3572417A3 (de) 2011-10-14 2020-03-25 Sage Therapeutics, Inc. 3,3-disubstituierte 19-nor-pregnan verbindungen, zusammensetzungen damit und verwendungen davon
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
RU2700264C2 (ru) 2013-04-17 2019-09-16 Сейдж Терапьютикс, Инк. 19-нор нейроактивные стероиды и способы их применения
KR102239541B1 (ko) 2013-04-17 2021-04-14 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
EP3868382A1 (de) 2013-07-19 2021-08-25 Sage Therapeutics, Inc. Neuroaktive steroide, zusammensetzungen und verwendungen davon
LT3488852T (lt) 2013-08-23 2021-02-25 Sage Therapeutics, Inc. Neuroaktyvūs steroidai, kompozicijos, ir jų naudojimas
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
LT3206493T (lt) 2014-10-16 2020-08-25 Sage Therapeutics, Inc. Kompozicijos ir būdai, skirti cns sutrikimams gydyti
BR112017007902B1 (pt) * 2014-10-16 2023-12-05 Sage Therapeutics, Inc Composto e seu sal, composição farmacêutica e uso do referido composto e seu sal na fabricação de um medicamento para o tratamento de distúrbios do sistema nervoso central
SI3224269T1 (sl) * 2014-11-27 2020-10-30 Sage Therapeutics, Inc. Sestavki in metode za zdravljenje CNS motenj
ES2857082T3 (es) 2015-01-26 2021-09-28 Sage Therapeutics Inc Composiciones y métodos para el tratamiento de trastornos del SNC
JP6875996B2 (ja) 2015-02-20 2021-05-26 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド、組成物、およびその使用
DK3481844T3 (da) 2016-07-11 2024-07-22 Sage Therapeutics Inc C7, C12 og C16 substituerede neuroaktive steroider og disses fremgangsmåder til anvendelse
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
WO2020243488A1 (en) 2019-05-31 2020-12-03 Sage Therapeutics, Inc. Neuroactive steroids and compositions thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1107662B (de) * 1959-07-04 1961-05-31 Merck Ag E Verfahren zur Herstellung von Mannichbasen von Steroiden bzw. von deren Saeureadditionssalzen
US3042691A (en) * 1960-05-11 1962-07-03 Pfizer & Co C 5alpha,21-dibromo-6beta-fluoro-21-methyl-pregnanes and process for making same
FR1764M (fr) * 1962-02-20 1963-04-08 Roussel Uclaf Nouveau médicament notamment pour le traitement des spasmes d'origine coronarienne ou viscérale.
US3201425A (en) * 1963-12-10 1965-08-17 American Cyanamid Co 20-alkoxy-delta20-21-carboxaldehydes of the pregnane series and method of preparing the same
GB1089945A (en) * 1965-09-23 1967-11-08 British Drug Houses Ltd Steroidal-6-spirocyclopropyl-4-en-3-ones
GB1317184A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Steroid-containing pharmaceutical preparations
DE1941226A1 (de) * 1969-08-13 1971-02-18 Degussa Basisch substituierte Ketosteroide
US3661940A (en) * 1970-04-13 1972-05-09 Sandoz Ag Derivatives of 21-methyl-19-norpregnanes
GB1377609A (en) * 1970-12-17 1974-12-18 Glaxo Lab Ltd 3alpha-hydroxy-5alpha-pregnane compounds
GB1416427A (en) * 1972-01-12 1975-12-03 Akzo Nv Alkylated pregnanes and process for obtaining same

Also Published As

Publication number Publication date
DK135775C (de) 1977-11-21
AU474687B2 (en) 1976-07-29
IE38863B1 (en) 1978-06-21
FR2184711A1 (de) 1973-12-28
DE2323950A1 (de) 1973-12-13
BE799433A (fr) 1973-11-12
FR2184711B1 (de) 1977-01-07
US3998829A (en) 1976-12-21
DK135775B (da) 1977-06-20
IE38863L (en) 1973-11-12
AU5561673A (en) 1974-11-14
JPS4948652A (de) 1974-05-11
NL7306606A (de) 1973-11-14
LU67585A1 (de) 1973-07-24
CA1014947A (en) 1977-08-02
GB1436324A (en) 1976-05-19

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