ZA695769B - New aryloxy compounds and methods for their production - Google Patents

New aryloxy compounds and methods for their production

Info

Publication number
ZA695769B
ZA695769B ZA695769A ZA695769A ZA695769B ZA 695769 B ZA695769 B ZA 695769B ZA 695769 A ZA695769 A ZA 695769A ZA 695769 A ZA695769 A ZA 695769A ZA 695769 B ZA695769 B ZA 695769B
Authority
ZA
South Africa
Prior art keywords
production
methods
aryloxy compounds
new aryloxy
new
Prior art date
Application number
ZA695769A
Other languages
English (en)
Inventor
P Creger
Original Assignee
Parke Davis & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US819126A priority Critical patent/US3674836A/en
Priority to DE19691925423 priority patent/DE1925423A1/de
Priority to GB2576069A priority patent/GB1225575A/en
Priority to FR6916281A priority patent/FR2008997A1/fr
Application filed by Parke Davis & Co filed Critical Parke Davis & Co
Priority to ZA695769A priority patent/ZA695769B/xx
Priority to AT782869A priority patent/AT291228B/de
Priority to NL696912790A priority patent/NL148872B/xx
Priority to BR211856/69A priority patent/BR6911856D0/pt
Publication of ZA695769B publication Critical patent/ZA695769B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA695769A 1968-05-21 1969-08-12 New aryloxy compounds and methods for their production ZA695769B (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US819126A US3674836A (en) 1968-05-21 1969-04-24 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
DE19691925423 DE1925423A1 (de) 1968-05-21 1969-05-19 2,2-Dimethyl-omega-aryloxyalkansaeuren und ihre Salze und Ester
GB2576069A GB1225575A (xx) 1968-05-21 1969-05-20
FR6916281A FR2008997A1 (xx) 1968-05-21 1969-05-20
ZA695769A ZA695769B (en) 1968-05-21 1969-08-12 New aryloxy compounds and methods for their production
AT782869A AT291228B (de) 1968-05-21 1969-08-14 Verfahren zur Herstellung neuer α,α-Dimethyl-ω-phenoxyalkansäuren, ihrer Salze oder Alkylester
NL696912790A NL148872B (nl) 1968-05-21 1969-08-21 Werkwijze ter bereiding van farmacologisch werkzame omega-aryloxyalkaancarbonzuurderivaten; werkwijze ter bereiding van farmaceutische preparaten en de aldus verkregen gevormde voortbrengselen.
BR211856/69A BR6911856D0 (pt) 1968-05-21 1969-08-26 Processo para a producao de novos compostos ariloxi

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US73094668A 1968-05-21 1968-05-21
US819126A US3674836A (en) 1968-05-21 1969-04-24 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
ZA695769A ZA695769B (en) 1968-05-21 1969-08-12 New aryloxy compounds and methods for their production
AT782869A AT291228B (de) 1968-05-21 1969-08-14 Verfahren zur Herstellung neuer α,α-Dimethyl-ω-phenoxyalkansäuren, ihrer Salze oder Alkylester
NL696912790A NL148872B (nl) 1968-05-21 1969-08-21 Werkwijze ter bereiding van farmacologisch werkzame omega-aryloxyalkaancarbonzuurderivaten; werkwijze ter bereiding van farmaceutische preparaten en de aldus verkregen gevormde voortbrengselen.
BR211856/69A BR6911856D0 (pt) 1968-05-21 1969-08-26 Processo para a producao de novos compostos ariloxi

Publications (1)

Publication Number Publication Date
ZA695769B true ZA695769B (en) 1971-03-31

Family

ID=36691343

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA695769A ZA695769B (en) 1968-05-21 1969-08-12 New aryloxy compounds and methods for their production

Country Status (8)

Country Link
US (1) US3674836A (xx)
AT (1) AT291228B (xx)
BR (1) BR6911856D0 (xx)
DE (1) DE1925423A1 (xx)
FR (1) FR2008997A1 (xx)
GB (1) GB1225575A (xx)
NL (1) NL148872B (xx)
ZA (1) ZA695769B (xx)

Families Citing this family (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971816A (en) * 1973-11-26 1976-07-27 Ceskoslovenska Akademie Ved Esters of carboxylic acids formally substituted by sodium or potassium in the alpha-position and the method for their preparation
US4012523A (en) * 1974-01-24 1977-03-15 The Dow Chemical Company Hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-(thio or sulfonyl) alkanoic acids and derivatives
US4067998A (en) * 1974-02-11 1978-01-10 The Dow Chemical Company 2-((3,5-Di-tert-butylphenyl)thio) alkanoic acids and derivatives
US4020177A (en) * 1974-08-30 1977-04-26 Merck & Co., Inc. Substituted phenoxy-tridecanoic acids
US4024182A (en) * 1975-08-15 1977-05-17 Sandoz, Inc. Preparation of aryl-butadienoic acids
US4126637A (en) * 1977-06-17 1978-11-21 Warner-Lambert Company Process for the production of 2,2-dimethyl-5-(2,5-xylyloxy)valeric acid
GB2025942A (en) * 1978-05-31 1980-01-30 Sori Soc Rech Ind Phenoxyalkylcarboxylic acids
US4285951A (en) * 1979-09-07 1981-08-25 Warner-Lambert Company 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentyl ester of 3-pyridine carboxylic acid and use as an anti-atherosclerotic agent
US4351950A (en) * 1980-01-02 1982-09-28 Warner-Lambert Company Anti-arteriosclerotic agents
US4477556A (en) * 1982-08-18 1984-10-16 E. I. Du Pont De Nemours And Company Acidic o-nitroaromatics as photoinhibitors of polymerization in positive working films
US4665226A (en) * 1985-12-09 1987-05-12 Warner-Lambert Company Process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
US4714762A (en) * 1986-10-31 1987-12-22 Warner-Lambert Company Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
EP0276807A3 (en) * 1987-01-27 1988-10-12 Warner-Lambert Company Lipid regulating compositions
US4973731A (en) * 1987-04-23 1990-11-27 Riker Laboratories, Inc. Di-t-butylphenyl alkyl and benzyl ether nitriles
US4859703A (en) * 1987-06-15 1989-08-22 Warner-Lambert Company Lipid regulating compositions
US4968710A (en) * 1987-11-13 1990-11-06 Riker Laboratories, Inc. Substituted di-t-butylphenols and anti-allergic use thereof
US5066822A (en) * 1987-11-13 1991-11-19 Riker Laboratories, Inc Di-t-butylphenols substituted by an alkoxy or benzyloxy group or a benzylthio group
US5260305A (en) * 1988-12-12 1993-11-09 E. R. Squibb & Sons, Inc. Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination
HU205891B (en) * 1990-05-11 1992-07-28 Gyogyszerkutato Intezet Process for producing 2,2-dimethyl-5-/2,5-dimethyl-phenoxy/-pentanoic acid
US5235097A (en) * 1990-05-11 1993-08-10 Egis Gyogyszergyar Process for the preparation of 2,2-dimethyl-5-(2,5-dimethyl-phenoxy)-pentanoic acid, intermediates for preparing this compound and process for preparing the intermediates
US5041640A (en) * 1990-09-20 1991-08-20 Warner-Lambert Company Process for mono-, di-, trisubstituted acetic acids
HU212428B (en) * 1994-05-13 1996-06-28 Egyt Gyogyszervegyeszeti Gyar Process to prepare pharmaceutical compositions containing gemfibrozyl
US5412112A (en) * 1994-06-14 1995-05-02 Industrial Technology Research Institute Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids
US5530145A (en) * 1994-06-14 1996-06-25 Syn-Tech Chem & Pharm Co., Ltd. Anticholesteremic compounds
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
IT1274355B (it) * 1994-12-21 1997-07-17 Alfa Wassermann Spa Lattoni ad attivita' antiossidante ed ipolipidemica utili nella terapia dell'aterosclerosi
DE4446387A1 (de) * 1994-12-23 1996-06-27 Basf Ag Verfahren zur Herstellung fester, freifließender wasserlöslicher Salze von Aryloxi-C¶1¶-C¶4¶-alkancarbonsäuren
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
US6713043B2 (en) * 1996-02-29 2004-03-30 The Trustees Of Columbia University In The City Of New York Antimicrobial activity of gemfibrozil
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
JP2001508795A (ja) * 1997-01-17 2001-07-03 ブリストル−マイヤーズ・スクイブ・カンパニー Ｍｔｐインヒビター単独またはこれと他のコレステロール降下薬を組合せて用いる心臓血管疾患の発病の危険を予防または軽減する方法
CA2286341A1 (en) * 1997-05-01 1998-11-12 John R. Ii Wetterau Mtp inhibitors and fat soluble vitamin therapeutic combinations to lower serum lipid levels
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
US6469035B1 (en) * 1997-07-31 2002-10-22 Eugenio A. Cefali Methods of pretreating hyperlipidemic individuals with a flush inhibiting agent prior to the start of single daily dose nicotinic acid therapy to reduce flushing provoked by nicotinic acid
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US6264960B1 (en) 1998-11-10 2001-07-24 Sander J. Robins Treatment of vascular events using lipid-modifying compositions
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
PL348609A1 (en) 1998-12-23 2002-06-03 Searle Llc Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications
CA2356515A1 (en) * 1998-12-23 2000-07-06 G.D. Searle Llc Combinations for cardiovascular indications
HUP0400886A2 (hu) * 1998-12-23 2004-07-28 G.D. Searle Llc Koleszteril-észter transzfer protein inhibitorok és fibrinsav-származékok kombinációi szív-érrendszeri indikációkhoz
ATE242008T1 (de) 1998-12-23 2003-06-15 Searle Llc Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
EP1140189B1 (en) 1998-12-23 2003-05-14 G.D. Searle LLC. Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
PL348508A1 (en) 1998-12-23 2002-05-20 Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
ES2201822T3 (es) * 1998-12-23 2004-03-16 G.D. Searle Llc Combinaciones de inhibididores de la proteina de transferencia de ester de colesterilo y de derivados de acido nicotinico para indicaciones cardiovasculares.
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
EP1286984A2 (en) 2000-03-10 2003-03-05 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
US20020061888A1 (en) * 2000-03-10 2002-05-23 Keller Bradley T. Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US6395767B2 (en) 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
JP2004536047A (ja) 2001-04-11 2004-12-02 ブリストル−マイヤーズ　スクイブ　カンパニー 糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
US7238671B2 (en) * 2001-10-18 2007-07-03 Bristol-Myers Squibb Company Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
GEP20063908B (en) * 2001-10-18 2006-08-25 Bristol Myers Squibb Co Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
US6806381B2 (en) * 2001-11-02 2004-10-19 Bristol-Myers Squibb Company Process for the preparation of aniline-derived thyroid receptor ligands
CA2464685A1 (en) * 2001-11-02 2003-05-15 G.D. Searle Llc Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
WO2003043624A1 (en) * 2001-11-16 2003-05-30 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US6852753B2 (en) 2002-01-17 2005-02-08 Pharmacia Corporation Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
CA2479338A1 (en) * 2002-03-20 2003-10-02 Metabolex, Inc. Substituted phenylacetic acids
US20040005358A1 (en) * 2002-04-23 2004-01-08 Slugg Peter H. Modified-release vasopeptidase inhibitor formulation, combinations and method
WO2003096548A2 (de) * 2002-05-14 2003-11-20 Siemens Aktiengesellschaft Verfahren zum erzeugen eines sendesignals
US7057046B2 (en) * 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
WO2004037181A2 (en) * 2002-10-23 2004-05-06 Bristol-Myers Squibb Company Glycinenitrile-based inhibitors of dipeptidyl peptidase iv and methods
US7098235B2 (en) * 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
RS20050890A (xx) * 2003-05-30 2007-12-31 Ranbaxy Laboratories Limited, Supstituisani pirol derivati
WO2004108126A1 (en) * 2003-06-06 2004-12-16 Snowden Pharmaceuticals, Llc Fibric acid derivatives for the treatment of irritable bowel syndrome
US7459474B2 (en) * 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
US6995183B2 (en) * 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
US7371759B2 (en) * 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
WO2005046662A2 (en) * 2003-11-07 2005-05-26 Jj Pharma, Inc. Hdl-boosting combination therapy complexes
EP1743676A1 (en) * 2003-11-12 2007-01-17 Phenomix Corporation Heterocyclic boronic acid derivatives, dipeptidyl peptidase IV inhibitors
US7317109B2 (en) * 2003-11-12 2008-01-08 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7576121B2 (en) * 2003-11-12 2009-08-18 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7767828B2 (en) * 2003-11-12 2010-08-03 Phenomix Corporation Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7420059B2 (en) * 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
RU2006145872A (ru) * 2004-05-25 2008-06-27 Метаболекс, Инк. (Us) Замещенные триазолы в качестве модуляторов ppar и способы их получения
EP1749000A4 (en) * 2004-05-25 2009-12-30 Metabolex Inc BICYCLIC SUBSTITUTED TRIAZOLE AS PPAR MODULATORS AND METHOD FOR THE PRODUCTION THEREOF
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
TW200611704A (en) * 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US7145040B2 (en) * 2004-07-02 2006-12-05 Bristol-Myers Squibb Co. Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
AR051446A1 (es) * 2004-09-23 2007-01-17 Bristol Myers Squibb Co Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
US7517991B2 (en) * 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
US7635699B2 (en) * 2004-12-29 2009-12-22 Bristol-Myers Squibb Company Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7589088B2 (en) * 2004-12-29 2009-09-15 Bristol-Myers Squibb Company Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
WO2006076597A1 (en) * 2005-01-12 2006-07-20 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
US7220859B2 (en) 2005-01-12 2007-05-22 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
WO2006076598A2 (en) * 2005-01-12 2006-07-20 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
US20060160850A1 (en) * 2005-01-18 2006-07-20 Chongqing Sun Bicyclic heterocycles as cannabinoid receptor modulators
EP1846410B1 (en) * 2005-02-10 2009-01-21 Bristol-Myers Squibb Company Dihydroquinazolinones as 5ht modulators
US20060235028A1 (en) 2005-04-14 2006-10-19 Li James J Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
US7521557B2 (en) 2005-05-20 2009-04-21 Bristol-Myers Squibb Company Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
US7825139B2 (en) * 2005-05-25 2010-11-02 Forest Laboratories Holdings Limited (BM) Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
AU2006249869A1 (en) * 2005-05-26 2006-11-30 Bristol-Myers Squibb Company N-terminally modified GLP-1 receptor modulators
US7632837B2 (en) * 2005-06-17 2009-12-15 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid-1 receptor modulators
US20060287342A1 (en) * 2005-06-17 2006-12-21 Mikkilineni Amarendra B Triazolopyrimidine heterocycles as cannabinoid receptor modulators
US7572808B2 (en) * 2005-06-17 2009-08-11 Bristol-Myers Squibb Company Triazolopyridine cannabinoid receptor 1 antagonists
US7629342B2 (en) * 2005-06-17 2009-12-08 Bristol-Myers Squibb Company Azabicyclic heterocycles as cannabinoid receptor modulators
US7317012B2 (en) * 2005-06-17 2008-01-08 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoind-1 receptor modulators
US7452892B2 (en) * 2005-06-17 2008-11-18 Bristol-Myers Squibb Company Triazolopyrimidine cannabinoid receptor 1 antagonists
CA2617102A1 (en) * 2005-07-28 2007-02-08 Bristol-Myers Squibb Company Substituted tetrahydro-1h-pyrido[4,3,b]indoles as serotonin receptor agonists and antagonists
US7795436B2 (en) * 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
AR056155A1 (es) * 2005-10-26 2007-09-19 Bristol Myers Squibb Co Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica
US7488725B2 (en) 2005-10-31 2009-02-10 Bristol-Myers Squibb Co. Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods
KR101329112B1 (ko) * 2005-11-08 2013-11-14 랜박시 래보러터리스 리미티드 (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2007082264A2 (en) * 2006-01-11 2007-07-19 Bristol-Myers Squibb Company Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US7553836B2 (en) * 2006-02-06 2009-06-30 Bristol-Myers Squibb Company Melanin concentrating hormone receptor-1 antagonists
CA2569776A1 (en) * 2006-02-17 2007-08-17 Kos Life Sciences, Inc. Low flush niacin formulation
WO2008020314A2 (en) * 2006-03-14 2008-02-21 Ranbaxy Laboratories Limited Statin stabilizing dosage formulations
US20070238770A1 (en) * 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
WO2007139589A1 (en) * 2006-05-26 2007-12-06 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
US20080044326A1 (en) * 2006-07-04 2008-02-21 Esencia Co., Ltd. Sterilizer for baby products
AU2007274724B2 (en) * 2006-07-14 2012-07-26 Ranbaxy Laboratories Limited Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
US20100210633A1 (en) * 2006-10-12 2010-08-19 Epix Delaware, Inc. Carboxamide compounds and their use
WO2008057862A2 (en) 2006-11-01 2008-05-15 Bristol-Myers Squibb Company MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
EP2114151A4 (en) * 2007-03-01 2010-03-17 Concourse Health Sciences Llc INOSITOL NIACINATE ISOMERS AND USES THEREOF
TW200901959A (en) 2007-03-09 2009-01-16 Indigene Pharmaceuticals Inc Combination of metformin R-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
PE20090185A1 (es) 2007-03-22 2009-02-28 Bristol Myers Squibb Co Formulaciones farmaceuticas que contienen un inhibidor sglt2
EP2142551B1 (en) 2007-04-17 2015-10-14 Bristol-Myers Squibb Company Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors
PE20090696A1 (es) 2007-04-20 2009-06-20 Bristol Myers Squibb Co Formas cristalinas de saxagliptina y procesos para preparar las mismas
CN101754972A (zh) * 2007-05-18 2010-06-23 百时美施贵宝公司 Sglt2抑制剂的晶体结构及其制备方法
US20090011994A1 (en) * 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
EP2173717B9 (en) * 2007-07-27 2013-06-26 Bristol-Myers Squibb Company Novel glucokinase activators and methods of using same
KR100836960B1 (ko) * 2007-09-07 2008-06-10 주식회사 서울제약 새로운 나이아신 제어방출형 제제
WO2009076404A1 (en) * 2007-12-10 2009-06-18 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
CA2708364A1 (en) 2007-12-11 2009-06-18 Efrat Ben-Zeev Carboxamide compounds and their use as chemokine receptor agonists
PE20091928A1 (es) * 2008-05-29 2009-12-31 Bristol Myers Squibb Co Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos
US20100256153A1 (en) 2009-03-27 2010-10-07 Bristol-Myers Squibb Company Methods for preventing or reducing risk of mortality
EP2498757A1 (en) 2009-11-13 2012-09-19 Bristol-Myers Squibb Company Reduced mass metformin formulations
RU2583920C2 (ru) 2009-11-13 2016-05-10 Астразенека Аб Композиция двухслойной таблетки
CA2780941C (en) 2009-11-13 2018-06-12 Bristol-Myers Squibb Company Immediate release tablet formulations
TWI562775B (en) 2010-03-02 2016-12-21 Lexicon Pharmaceuticals Inc Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
WO2011130459A1 (en) 2010-04-14 2011-10-20 Bristol-Myers Squibb Company Novel glucokinase activators and methods of using same
JP6042330B2 (ja) 2010-07-09 2016-12-14 ビーエイチヴィ ファーマ、インコーポレイテッド レモグリフロジンを含めた半減期が短い医薬品のための組合せ即時／遅延放出送達システム
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
TWI631963B (zh) 2011-01-05 2018-08-11 雷西肯製藥股份有限公司 包含鈉－葡萄糖共同輸送體１與２之抑制劑的組合物與應用方法
WO2014039411A1 (en) 2012-09-05 2014-03-13 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormore receptor-1 antagonists
WO2014039412A1 (en) 2012-09-05 2014-03-13 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
PT2925735T (pt) 2012-11-20 2019-06-04 Lexicon Pharmaceuticals Inc Inibidores do cotransportador de sódio e glucose 1
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
WO2015027021A1 (en) 2013-08-22 2015-02-26 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
WO2016038520A1 (en) * 2014-09-08 2016-03-17 Sun Pharmaceutical Industries Limited Processes for the preparation of ticagrelor and its intermediates
AU2016215179B2 (en) 2015-02-06 2021-02-25 Intercept Pharmaceuticals, Inc. Pharmaceutical compositions for combination therapy
SG11201708323SA (en) 2015-04-30 2017-11-29 Harvard College Anti-ap2 antibodies and antigen binding agents to treat metabolic disorders
JP2021530517A (ja) 2018-07-19 2021-11-11 アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag ダパグリフロジンを使用してＨＦｐＥＦを処置する方法、及びダパグリフロジンを含む組成物
CN110857268B (zh) * 2018-08-23 2022-10-04 青岛睿森生物科技有限公司 苯氧酸类化合物及其医药用途
MX2021003545A (es) 2018-09-26 2021-05-27 Lexicon Pharmaceuticals Inc Formas solidas cristalinas de n-(1-((2-(dimetilamino)etil)amino)-2 -metil-1-oxopropan-2-il)-4-(4-(2-metil-5-((2s,3r,4r,5s,6r)-3,4,5- trihidroxi-6-(metiltio)tetrahidro-2h-piran-2-il)bencil)fenil)buta namida y metodos para su sintesis.
EP3976049A1 (en) 2019-05-30 2022-04-06 Intercept Pharmaceuticals, Inc. Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6679625D0 (pt) * 1965-05-27 1973-10-23 Merck & Co Inc Processo para preparar acidos carboxilicos
FR1498459A (xx) * 1965-07-30 1968-01-08

Also Published As

Publication number Publication date
NL148872B (nl) 1976-03-15
AT291228B (de) 1971-07-12
DE1925423A1 (de) 1969-11-27
NL6912790A (en) 1971-02-23
US3674836A (en) 1972-07-04
GB1225575A (xx) 1971-03-17
FR2008997A1 (xx) 1970-01-30
BR6911856D0 (pt) 1973-02-13

Similar Documents

Publication Publication Date Title
ZA695769B (en) New aryloxy compounds and methods for their production
IL32288A0 (en) New penicillins and their production
ZA737696B (en) New pyrazolodiazepine compounds and methods for their production
MY7300458A (en) 1-hydroxy-2-pyridones and process for their manufacture
PH9299A (en) Synthetic gas process
IE33126B1 (en) New pyrazolodiazepinone compounds and methods for their production
IL33026A0 (en) Process for the production of 2-acyloxy-thionobenzamides,and new 2-acyloxy-thionobenzamides
IL31463A0 (en) 1-formyl-3-nitro-azacycloalkan-2-ones and process for their production
IL33146A0 (en) Perchlorination process
IL33467A0 (en) Cardio-active oxido-cardadienolides or oxido-bufatrienolides and process for their manufacture
IL37210A (en) Amino-s-triazolylbenzene-sulfonamide derivatives and methods for their production
ZA713541B (en) Tropan-3-ol-derivatives and processes for their production
MY7600086A (en) Novel 1-polyfluoroalkyl-benzodiazepines and methods for their production
IL35891A (en) New thienobenzothiepinopyrrole derivatives and their production
ZA694415B (en) Separation process
IL31669A0 (en) Thiopyranothienopyrimidines and process for their manufacture
IL34893A0 (en) N-fluorosulphonyl compounds and their production
ZA697042B (en) New esters and their production
PH10699A (en) 2-iminobenzodiazepine derivatives and process for their production
IL31754A0 (en) Threo-phenylalkanolamines and processes for the production thereof
ZA696156B (en) Spray-cooking process
IE33715B1 (en) New tetrahydrobenzothienodiazepinone compounds and methods for their production
IL31786A (en) Process for the production of (-)-norsco-polamine
IL31462A0 (en) 1-formyl-2-halogeno-azacyclo-alkenes and process for their production
CA775568A (en) Benzanilide compounds and methods for their production