ZA202306507B - Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions - Google Patents

Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions

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Publication number
ZA202306507B
ZA202306507B ZA2023/06507A ZA202306507A ZA202306507B ZA 202306507 B ZA202306507 B ZA 202306507B ZA 2023/06507 A ZA2023/06507 A ZA 2023/06507A ZA 202306507 A ZA202306507 A ZA 202306507A ZA 202306507 B ZA202306507 B ZA 202306507B
Authority
ZA
South Africa
Prior art keywords
ttr
transthyretin
treating
associated diseases
methods
Prior art date
Application number
ZA2023/06507A
Other languages
English (en)
Inventor
Chan Amy
Vest John
Robbie Gabriel
Z Attarwala Husain
Goel Varun
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of ZA202306507B publication Critical patent/ZA202306507B/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA2023/06507A 2016-12-16 2023-06-23 Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions ZA202306507B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662435127P 2016-12-16 2016-12-16

Publications (1)

Publication Number Publication Date
ZA202306507B true ZA202306507B (en) 2025-04-30

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ZA2023/06507A ZA202306507B (en) 2016-12-16 2023-06-23 Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions

Country Status (9)

Country Link
US (2) US20190350962A1 (https=)
EP (1) EP3555292A1 (https=)
JP (4) JP7058656B2 (https=)
KR (2) KR20230166146A (https=)
AU (2) AU2017376950B2 (https=)
SG (1) SG10201913552UA (https=)
TW (2) TWI790217B (https=)
WO (1) WO2018112320A1 (https=)
ZA (1) ZA202306507B (https=)

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