ZA201701132B - Novel 2,5-substituted pyrimidines as pde inhibitors - Google Patents

Novel 2,5-substituted pyrimidines as pde inhibitors

Info

Publication number
ZA201701132B
ZA201701132B ZA2017/01132A ZA201701132A ZA201701132B ZA 201701132 B ZA201701132 B ZA 201701132B ZA 2017/01132 A ZA2017/01132 A ZA 2017/01132A ZA 201701132 A ZA201701132 A ZA 201701132A ZA 201701132 B ZA201701132 B ZA 201701132B
Authority
ZA
South Africa
Prior art keywords
novel
substituted pyrimidines
pde inhibitors
pde
inhibitors
Prior art date
Application number
ZA2017/01132A
Other languages
English (en)
Inventor
Ingo Konetzki
Tobias Craan
Florian Jakob
Antonio Nardi
Christian Hesslinger
Andre Welbers
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of ZA201701132B publication Critical patent/ZA201701132B/en

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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ZA2017/01132A 2014-07-16 2017-02-15 Novel 2,5-substituted pyrimidines as pde inhibitors ZA201701132B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14002451 2014-07-16
PCT/EP2015/001475 WO2016008592A1 (en) 2014-07-16 2015-07-16 Novel 2,5-substituted pyrimidines as pde inhibitors

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ZA201701132B true ZA201701132B (en) 2019-07-31

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