ZA201501795B - Method of synthesizing thyroid hormone analogs and polymorphs thereof - Google Patents

Method of synthesizing thyroid hormone analogs and polymorphs thereof

Info

Publication number
ZA201501795B
ZA201501795B ZA2015/01795A ZA201501795A ZA201501795B ZA 201501795 B ZA201501795 B ZA 201501795B ZA 2015/01795 A ZA2015/01795 A ZA 2015/01795A ZA 201501795 A ZA201501795 A ZA 201501795A ZA 201501795 B ZA201501795 B ZA 201501795B
Authority
ZA
South Africa
Prior art keywords
polymorphs
thyroid hormone
hormone analogs
synthesizing
synthesizing thyroid
Prior art date
Application number
ZA2015/01795A
Other languages
English (en)
Inventor
D Keith Hester
Martha Kelly
Gang Dong
Rebecca Taub
Duk Soon Choi
Ping Wang
Robert J Duguid
Anna Chasnoff
Edwin L Crow
Charles H Reynolds
Lianhe Shu
Original Assignee
Madrigal Pharmaceuticals Inc
F Hoffmann La Roche Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madrigal Pharmaceuticals Inc, F Hoffmann La Roche Ltd filed Critical Madrigal Pharmaceuticals Inc
Publication of ZA201501795B publication Critical patent/ZA201501795B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
ZA2015/01795A 2012-09-17 2015-03-16 Method of synthesizing thyroid hormone analogs and polymorphs thereof ZA201501795B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261702137P 2012-09-17 2012-09-17
US201361790432P 2013-03-15 2013-03-15
PCT/US2013/060177 WO2014043706A1 (en) 2012-09-17 2013-09-17 Method of synthesizing thyroid hormone analogs and polymorphs thereof

Publications (1)

Publication Number Publication Date
ZA201501795B true ZA201501795B (en) 2021-10-27

Family

ID=50278769

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2015/01795A ZA201501795B (en) 2012-09-17 2015-03-16 Method of synthesizing thyroid hormone analogs and polymorphs thereof

Country Status (21)

Country Link
US (8) US9266861B2 (en:Method)
EP (4) EP2895466B1 (en:Method)
JP (7) JP6616688B2 (en:Method)
KR (4) KR20200023528A (en:Method)
CN (2) CN108101851A (en:Method)
AR (1) AR092872A1 (en:Method)
AU (1) AU2013315017C1 (en:Method)
BR (2) BR112015005891A2 (en:Method)
CA (3) CA2884481C (en:Method)
DK (2) DK2895466T3 (en:Method)
ES (2) ES2795450T3 (en:Method)
IL (7) IL288133B2 (en:Method)
IN (1) IN2015DN03133A (en:Method)
MX (2) MX395148B (en:Method)
MY (1) MY170520A (en:Method)
NZ (2) NZ739645A (en:Method)
RU (2) RU2668960C2 (en:Method)
SG (3) SG11201501907YA (en:Method)
TW (4) TWI804870B (en:Method)
WO (1) WO2014043706A1 (en:Method)
ZA (1) ZA201501795B (en:Method)

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AU2013315017B2 (en) 2017-07-27
KR102138750B1 (ko) 2020-07-29
IL275393A (en) 2020-07-30
US11986481B2 (en) 2024-05-21
JP2020015739A (ja) 2020-01-30
CA3111317C (en) 2023-08-29
IL275393B (en) 2022-01-01
IL314360A (en) 2024-09-01
US10376517B2 (en) 2019-08-13
EP4406594A3 (en) 2024-11-06
CN108101851A (zh) 2018-06-01
AU2013315017C1 (en) 2017-11-23
US20240148742A1 (en) 2024-05-09
RU2015114327A (ru) 2016-11-10
IL314360B2 (en) 2025-09-01
EP2895466B1 (en) 2020-03-25
RU2668960C2 (ru) 2018-10-05
ES2907926T3 (es) 2022-04-27
CN105008335B (zh) 2018-12-21
US20190381053A1 (en) 2019-12-19
TW201425300A (zh) 2014-07-01
DK3689853T3 (da) 2022-03-07
IL288133A (en) 2022-01-01
JP6532931B2 (ja) 2019-06-19
SG10201705984XA (en) 2017-08-30
JP6899413B2 (ja) 2021-07-07
IL237628A0 (en) 2015-04-30
EP2895466A4 (en) 2016-08-10
SG11201501907YA (en) 2015-04-29
JP6765408B2 (ja) 2020-10-07
EP4406594A2 (en) 2024-07-31
US11564926B2 (en) 2023-01-31
KR102363776B1 (ko) 2022-02-15
KR20210083381A (ko) 2021-07-06
MY170520A (en) 2019-08-08
RU2018128393A3 (en:Method) 2019-04-16
TWI755628B (zh) 2022-02-21
US9968612B2 (en) 2018-05-15
EP4023641B1 (en) 2024-05-01
US20150203473A1 (en) 2015-07-23
IL288133B1 (en) 2024-08-01
MX2018014924A (es) 2020-09-02
EP3689853B1 (en) 2021-11-24
EP3689853A1 (en) 2020-08-05
EP2895466A1 (en) 2015-07-22
US20240122936A1 (en) 2024-04-18
US20180228807A1 (en) 2018-08-16
SG10202006058QA (en) 2020-08-28
WO2014043706A8 (en) 2017-10-19
IL320269A (en) 2025-06-01
NZ705827A (en) 2018-07-27
EP4023641A2 (en) 2022-07-06
TW201946917A (zh) 2019-12-16
MX395148B (es) 2025-03-24
JP6616688B2 (ja) 2019-12-04
TW202134217A (zh) 2021-09-16
US10894050B2 (en) 2021-01-19
JP2019048856A (ja) 2019-03-28
JP2022078218A (ja) 2022-05-24
ES2795450T3 (es) 2020-11-23
AR092872A1 (es) 2015-05-06
US9266861B2 (en) 2016-02-23
BR112015005891A2 (pt) 2017-08-08
IL259610B (en) 2020-06-30
JP2020109090A (ja) 2020-07-16
KR20180131647A (ko) 2018-12-10
CN105008335A (zh) 2015-10-28
TWI652260B (zh) 2019-03-01
TWI804870B (zh) 2023-06-11
IL314360B1 (en) 2025-05-01
KR20200023528A (ko) 2020-03-04
MX364661B (es) 2019-05-03
MX2015003418A (es) 2016-04-04
KR20150056630A (ko) 2015-05-26
CA3090070A1 (en) 2014-03-20
JP2024056793A (ja) 2024-04-23
CA2884481C (en) 2021-04-27
JP2015535817A (ja) 2015-12-17
JP2018080188A (ja) 2018-05-24
AU2013315017A1 (en) 2015-04-02
CA3111317A1 (en) 2014-03-20
BR122021024202B1 (pt) 2022-05-17
HK1212682A1 (en) 2016-06-17
EP4023641A3 (en) 2022-09-14
KR101966490B1 (ko) 2019-08-14
IL237628B (en) 2019-07-31
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