ZA201404091B - Oral spray formulations and methods for administration of sildenafil - Google Patents
Oral spray formulations and methods for administration of sildenafilInfo
- Publication number
- ZA201404091B ZA201404091B ZA2014/04091A ZA201404091A ZA201404091B ZA 201404091 B ZA201404091 B ZA 201404091B ZA 2014/04091 A ZA2014/04091 A ZA 2014/04091A ZA 201404091 A ZA201404091 A ZA 201404091A ZA 201404091 B ZA201404091 B ZA 201404091B
- Authority
- ZA
- South Africa
- Prior art keywords
- sildenafil
- administration
- methods
- spray formulations
- oral spray
- Prior art date
Links
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 title 2
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229940041678 oral spray Drugs 0.000 title 1
- 239000000668 oral spray Substances 0.000 title 1
- 229960003310 sildenafil Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161566879P | 2011-12-05 | 2011-12-05 | |
| PCT/US2012/067763 WO2013085904A1 (en) | 2011-12-05 | 2012-12-04 | Oral spray formulations and methods for administration of sildenafil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201404091B true ZA201404091B (en) | 2017-11-29 |
Family
ID=47430090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2014/04091A ZA201404091B (en) | 2011-12-05 | 2014-06-05 | Oral spray formulations and methods for administration of sildenafil |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9186321B2 (enExample) |
| EP (1) | EP2787967B1 (enExample) |
| JP (1) | JP6047174B2 (enExample) |
| KR (1) | KR20140117360A (enExample) |
| CN (1) | CN104822368B (enExample) |
| AU (1) | AU2012347997B2 (enExample) |
| BR (1) | BR112014013650A2 (enExample) |
| CA (1) | CA2858364C (enExample) |
| IL (1) | IL232970A0 (enExample) |
| RU (1) | RU2611403C1 (enExample) |
| SG (1) | SG11201402938RA (enExample) |
| WO (1) | WO2013085904A1 (enExample) |
| ZA (1) | ZA201404091B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015070049A1 (en) * | 2013-11-08 | 2015-05-14 | Insys Pharma, Inc. | Sildenafil sublingual spray formulation |
| NO2723977T3 (enExample) * | 2014-03-19 | 2018-03-10 | ||
| US10111833B2 (en) | 2015-04-03 | 2018-10-30 | Insys Development Company, Inc. | Sildenafil sublingual spray formulations |
| CN108367010A (zh) * | 2015-04-03 | 2018-08-03 | 因塞斯发展股份有限公司 | 西地那非舌下喷雾制剂 |
| BR102015020720A2 (pt) * | 2015-08-27 | 2017-03-01 | Henrique Leonardo Pereira Luis | composição hidrofíilica atóxica, bioidêntica e biodegradável à base de partículas micronizadas de acido hialurônico, com propriedades mucoadesivas e carreadoras via transmucosa aglutinadas por bioengenharia a um ipde5, para tratamento de disfunção erétil, com aplicação em sistema de spray de aerossol sublingual |
| WO2018070971A1 (ru) * | 2016-10-10 | 2018-04-19 | Товарыство З Обмэжэною Видповидальнистю Науково-Выробныча Фирма "Микрохим" | Фармацевтическая композиция в форме оромукозного спрея для лечения эректильной дисфункции и легочной артериальной гипертензии |
| WO2018076074A1 (en) * | 2016-10-31 | 2018-05-03 | Suda Ltd | Mucosal active agent delivery |
| CN114641276A (zh) * | 2019-11-07 | 2022-06-17 | 诺和诺德股份有限公司 | 包含glp-1激动剂、sglt2抑制剂和n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐的固体组合物 |
| CN111110633B (zh) * | 2020-01-21 | 2022-12-02 | 合肥医工医药股份有限公司 | 一种他达拉非喷雾剂及其制备方法 |
| EP4255389A1 (en) * | 2020-12-04 | 2023-10-11 | Tygrus LLC | Therapeutic material with low ph and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030082107A1 (en) * | 1997-10-01 | 2003-05-01 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer |
| US20030077229A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
| DE19834506A1 (de) | 1998-07-31 | 2000-02-03 | Hexal Ag | Transmucosales therapeutisches System zur Anwendung von Sildenafil |
| JP2002533380A (ja) * | 1998-12-23 | 2002-10-08 | アルザ・コーポレーション | 多孔性粒子を含む剤形 |
| IL139454A0 (en) * | 1999-11-08 | 2001-11-25 | Pfizer | Compounds for the treatment of female sexual dysfunction |
| CA2391968A1 (en) * | 1999-11-18 | 2001-05-25 | Natco Pharma Limited | An improved pharmaceutical composition for treating male erectile dysfunction |
| CN1277021A (zh) * | 2000-06-20 | 2000-12-20 | 王建华 | 一种治疗阳痿病的喷雾剂药物及其制备方法 |
| DE10248601B4 (de) * | 2002-10-17 | 2006-05-24 | Goldstein, Naum, Dr.habil.nat. | Pharmazeutisches Mittel zur endonasalen Applikation bei der Behandlung von Krankheiten und Störungen des zentralen Nervensystems |
| US7554270B2 (en) * | 2003-05-28 | 2009-06-30 | Tokyo Ohka Kogyo Co., Ltd. | Composition for dielectric of plasma display panel, laminate for dielectric, and method for forming the dielectric |
| WO2005077374A1 (en) | 2004-02-06 | 2005-08-25 | Becton, Dickinson And Company | Formulations of phosphodiesterase 5 inhibitors and methods of use |
| JP2008510825A (ja) * | 2004-08-23 | 2008-04-10 | マンカインド コーポレイション | ホスホジエステラーゼ５型の阻害剤の肺送達 |
| JP2008546786A (ja) * | 2005-06-23 | 2008-12-25 | シェーリング コーポレイション | Ｐｄｅ５インヒビターの迅速吸収性経口処方物 |
| BRPI0706395A2 (pt) * | 2006-01-11 | 2011-03-22 | Astrazeneca Ab | composto, uso do mesmo, métodos para produzir um efeito anti-proliferativo em um animal de sangue quente e para tratar doença, composição farmacêutica, e, processo para preparar um composto |
| EP2046274A1 (en) * | 2006-08-02 | 2009-04-15 | Wm. Wrigley Jr. Company | Oral compositions effective for the treatment of oral cavity malodor associated with the consumption of odor-causing compounds |
| JP5686978B2 (ja) * | 2009-03-18 | 2015-03-18 | 第一三共ヘルスケア株式会社 | シルデナフィルクエン酸塩含有内服液剤及びその液剤含有容器 |
-
2012
- 2012-12-04 RU RU2014123435A patent/RU2611403C1/ru not_active IP Right Cessation
- 2012-12-04 SG SG11201402938RA patent/SG11201402938RA/en unknown
- 2012-12-04 EP EP12806256.9A patent/EP2787967B1/en active Active
- 2012-12-04 CA CA2858364A patent/CA2858364C/en not_active Expired - Fee Related
- 2012-12-04 WO PCT/US2012/067763 patent/WO2013085904A1/en not_active Ceased
- 2012-12-04 US US14/363,245 patent/US9186321B2/en not_active Expired - Fee Related
- 2012-12-04 KR KR1020147016435A patent/KR20140117360A/ko not_active Ceased
- 2012-12-04 AU AU2012347997A patent/AU2012347997B2/en not_active Ceased
- 2012-12-04 CN CN201280068898.5A patent/CN104822368B/zh not_active Expired - Fee Related
- 2012-12-04 JP JP2014545981A patent/JP6047174B2/ja not_active Expired - Fee Related
- 2012-12-04 BR BR112014013650A patent/BR112014013650A2/pt not_active Application Discontinuation
-
2014
- 2014-06-05 ZA ZA2014/04091A patent/ZA201404091B/en unknown
- 2014-06-05 IL IL232970A patent/IL232970A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2858364C (en) | 2018-07-24 |
| KR20140117360A (ko) | 2014-10-07 |
| CN104822368A (zh) | 2015-08-05 |
| SG11201402938RA (en) | 2014-07-30 |
| EP2787967A1 (en) | 2014-10-15 |
| CA2858364A1 (en) | 2013-06-13 |
| US20150051216A1 (en) | 2015-02-19 |
| RU2611403C1 (ru) | 2017-02-21 |
| US9186321B2 (en) | 2015-11-17 |
| CN104822368B (zh) | 2019-01-11 |
| EP2787967B1 (en) | 2018-10-31 |
| WO2013085904A1 (en) | 2013-06-13 |
| JP2015500285A (ja) | 2015-01-05 |
| JP6047174B2 (ja) | 2016-12-21 |
| AU2012347997A1 (en) | 2014-07-03 |
| HK1199843A1 (en) | 2015-07-24 |
| NZ625922A (en) | 2015-05-29 |
| AU2012347997B2 (en) | 2017-07-20 |
| IL232970A0 (en) | 2014-08-31 |
| BR112014013650A2 (pt) | 2017-07-04 |
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