ZA201306719B - 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace) - Google Patents

3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace)

Info

Publication number
ZA201306719B
ZA201306719B ZA2013/06719A ZA201306719A ZA201306719B ZA 201306719 B ZA201306719 B ZA 201306719B ZA 2013/06719 A ZA2013/06719 A ZA 2013/06719A ZA 201306719 A ZA201306719 A ZA 201306719A ZA 201306719 B ZA201306719 B ZA 201306719B
Authority
ZA
South Africa
Prior art keywords
bace
secretase
pyrazin
pyrrolo
dihydro
Prior art date
Application number
ZA2013/06719A
Other languages
English (en)
Inventor
Andres Avelino Trabanco-Suarez
Francisca Delgado-Jimenez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA201306719B publication Critical patent/ZA201306719B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA2013/06719A 2011-03-09 2013-09-06 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace) ZA201306719B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11157418 2011-03-09
PCT/EP2012/053863 WO2012120023A1 (en) 2011-03-09 2012-03-07 3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

Publications (1)

Publication Number Publication Date
ZA201306719B true ZA201306719B (en) 2015-04-29

Family

ID=43833325

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2013/06719A ZA201306719B (en) 2011-03-09 2013-09-06 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace)

Country Status (20)

Country Link
US (1) US9845326B2 (enExample)
EP (1) EP2683721B1 (enExample)
JP (1) JP5853035B2 (enExample)
KR (1) KR102012675B1 (enExample)
CN (1) CN103415521B (enExample)
AU (1) AU2012224632B2 (enExample)
BR (1) BR112013022917A2 (enExample)
CA (1) CA2825620C (enExample)
CL (1) CL2013002511A1 (enExample)
CO (1) CO6751283A2 (enExample)
EA (1) EA023824B1 (enExample)
ES (1) ES2534973T3 (enExample)
IL (1) IL228239A (enExample)
MX (1) MX340031B (enExample)
MY (1) MY163346A (enExample)
PH (1) PH12013501805A1 (enExample)
SG (1) SG193342A1 (enExample)
UA (1) UA109687C2 (enExample)
WO (1) WO2012120023A1 (enExample)
ZA (1) ZA201306719B (enExample)

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KR102243135B1 (ko) * 2013-06-12 2021-04-22 얀센 파마슈티카 엔.브이. 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진-3(2h)-온 유도체
RU2572076C2 (ru) * 2014-03-26 2015-12-27 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" 1-арилпирроло[1,2-a]пиразин-3-карбоксамиды с нейропсихотропной активностью
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KR102243135B1 (ko) 2013-06-12 2021-04-22 얀센 파마슈티카 엔.브이. 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진-3(2h)-온 유도체
EP3233834B1 (en) 2014-12-18 2019-11-13 Janssen Pharmaceutica NV 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine derivatives useful as inhibitors of beta-secretase

Also Published As

Publication number Publication date
MY163346A (en) 2017-09-15
JP5853035B2 (ja) 2016-02-09
CA2825620A1 (en) 2012-09-13
JP2014507455A (ja) 2014-03-27
NZ615720A (en) 2014-08-29
AU2012224632B2 (en) 2016-06-16
EA023824B1 (ru) 2016-07-29
WO2012120023A1 (en) 2012-09-13
MX2013010280A (es) 2013-10-01
CA2825620C (en) 2019-04-23
KR102012675B1 (ko) 2019-08-21
PH12013501805A1 (en) 2013-11-18
BR112013022917A2 (pt) 2016-12-06
UA109687C2 (xx) 2015-09-25
IL228239A (en) 2016-06-30
CN103415521B (zh) 2016-01-06
IL228239A0 (en) 2013-11-25
SG193342A1 (en) 2013-10-30
MX340031B (es) 2016-06-21
KR20140019332A (ko) 2014-02-14
EP2683721B1 (en) 2015-01-28
US20130345228A1 (en) 2013-12-26
EA201391296A1 (ru) 2014-01-30
ES2534973T3 (es) 2015-04-30
HK1189223A1 (zh) 2014-05-30
US9845326B2 (en) 2017-12-19
CN103415521A (zh) 2013-11-27
EP2683721A1 (en) 2014-01-15
AU2012224632A1 (en) 2013-08-01
CL2013002511A1 (es) 2014-01-24
CO6751283A2 (es) 2013-09-16

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