CA2825620C - 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace) - Google Patents

3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace) Download PDF

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Publication number
CA2825620C
CA2825620C CA2825620A CA2825620A CA2825620C CA 2825620 C CA2825620 C CA 2825620C CA 2825620 A CA2825620 A CA 2825620A CA 2825620 A CA2825620 A CA 2825620A CA 2825620 C CA2825620 C CA 2825620C
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mmol
mixture
compound
yield
3alkyl
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French (fr)
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CA2825620A1 (en
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Andres Avelino Trabanco-Suarez
Francisca Delgado-Jimenez
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2825620A 2011-03-09 2012-03-07 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace) Active CA2825620C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11157418 2011-03-09
EP11157418.2 2011-03-09
PCT/EP2012/053863 WO2012120023A1 (en) 2011-03-09 2012-03-07 3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

Publications (2)

Publication Number Publication Date
CA2825620A1 CA2825620A1 (en) 2012-09-13
CA2825620C true CA2825620C (en) 2019-04-23

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CA2825620A Active CA2825620C (en) 2011-03-09 2012-03-07 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace)

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Country Link
US (1) US9845326B2 (enExample)
EP (1) EP2683721B1 (enExample)
JP (1) JP5853035B2 (enExample)
KR (1) KR102012675B1 (enExample)
CN (1) CN103415521B (enExample)
AU (1) AU2012224632B2 (enExample)
BR (1) BR112013022917A2 (enExample)
CA (1) CA2825620C (enExample)
CL (1) CL2013002511A1 (enExample)
CO (1) CO6751283A2 (enExample)
EA (1) EA023824B1 (enExample)
ES (1) ES2534973T3 (enExample)
IL (1) IL228239A (enExample)
MX (1) MX340031B (enExample)
MY (1) MY163346A (enExample)
PH (1) PH12013501805A1 (enExample)
SG (1) SG193342A1 (enExample)
UA (1) UA109687C2 (enExample)
WO (1) WO2012120023A1 (enExample)
ZA (1) ZA201306719B (enExample)

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AU2012224632B2 (en) 2016-06-16
WO2012120023A1 (en) 2012-09-13
IL228239A0 (en) 2013-11-25
HK1189223A1 (zh) 2014-05-30
CL2013002511A1 (es) 2014-01-24
EP2683721B1 (en) 2015-01-28
MY163346A (en) 2017-09-15
CN103415521B (zh) 2016-01-06
PH12013501805A1 (en) 2013-11-18
CN103415521A (zh) 2013-11-27
UA109687C2 (xx) 2015-09-25
CO6751283A2 (es) 2013-09-16
MX2013010280A (es) 2013-10-01
US20130345228A1 (en) 2013-12-26
IL228239A (en) 2016-06-30
SG193342A1 (en) 2013-10-30
KR102012675B1 (ko) 2019-08-21
AU2012224632A1 (en) 2013-08-01
JP5853035B2 (ja) 2016-02-09
ES2534973T3 (es) 2015-04-30
EA201391296A1 (ru) 2014-01-30
EP2683721A1 (en) 2014-01-15
NZ615720A (en) 2014-08-29
ZA201306719B (en) 2015-04-29
BR112013022917A2 (pt) 2016-12-06
JP2014507455A (ja) 2014-03-27
CA2825620A1 (en) 2012-09-13
US9845326B2 (en) 2017-12-19
KR20140019332A (ko) 2014-02-14
EA023824B1 (ru) 2016-07-29
MX340031B (es) 2016-06-21

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