ZA201202418B - Antibodies specific for claudin 6 (cldn6) - Google Patents

Antibodies specific for claudin 6 (cldn6)

Info

Publication number
ZA201202418B
ZA201202418B ZA2012/02418A ZA201202418A ZA201202418B ZA 201202418 B ZA201202418 B ZA 201202418B ZA 2012/02418 A ZA2012/02418 A ZA 2012/02418A ZA 201202418 A ZA201202418 A ZA 201202418A ZA 201202418 B ZA201202418 B ZA 201202418B
Authority
ZA
South Africa
Prior art keywords
cldn6
claudin
antibodies specific
antibodies
specific
Prior art date
Application number
ZA2012/02418A
Other languages
English (en)
Inventor
Ugur Sahin
Ozlem Tureci
Michael Koslowski
Korden Walter
Stefan Woll
Maria Kreuzberg
Bernd Hubner
Michael Erdeljan
Original Assignee
Ganymed Pharmaceuticals Ag
Johannes Gutenberg-Universitat Mainz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09014136A external-priority patent/EP2322555A1/en
Application filed by Ganymed Pharmaceuticals Ag, Johannes Gutenberg-Universitat Mainz filed Critical Ganymed Pharmaceuticals Ag
Publication of ZA201202418B publication Critical patent/ZA201202418B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/02—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from eggs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
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ZA2012/02418A 2009-11-11 2012-04-03 Antibodies specific for claudin 6 (cldn6) ZA201202418B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26020209P 2009-11-11 2009-11-11
EP09014136A EP2322555A1 (en) 2009-11-11 2009-11-11 Antibodies specific for claudin 6 (CLDN6)
US36161810P 2010-07-06 2010-07-06
EP10006956 2010-07-06
PCT/EP2010/006888 WO2011057788A1 (en) 2009-11-11 2010-11-11 Antibodies specific for claudin 6 (cldn6)

Publications (1)

Publication Number Publication Date
ZA201202418B true ZA201202418B (en) 2013-06-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2012/02418A ZA201202418B (en) 2009-11-11 2012-04-03 Antibodies specific for claudin 6 (cldn6)

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Country Link
US (5) US9487584B2 (https=)
EP (4) EP3689911B1 (https=)
JP (3) JP5889196B2 (https=)
KR (4) KR101960509B1 (https=)
CN (4) CN106432500B (https=)
AU (3) AU2010318316B2 (https=)
BR (1) BR112012011143B1 (https=)
CA (2) CA3050655C (https=)
CY (2) CY1120300T1 (https=)
DK (2) DK3305813T3 (https=)
ES (3) ES2784483T3 (https=)
HR (2) HRP20171749T1 (https=)
HU (2) HUE035516T2 (https=)
IL (2) IL218628B (https=)
LT (2) LT3305813T (https=)
ME (1) ME02943B (https=)
MX (3) MX385874B (https=)
NO (1) NO2499161T3 (https=)
NZ (2) NZ734307A (https=)
PL (3) PL3305813T3 (https=)
PT (2) PT2499161T (https=)
RS (2) RS60168B1 (https=)
RU (1) RU2675997C2 (https=)
SG (2) SG10201500975YA (https=)
SI (2) SI3305813T1 (https=)
SM (1) SMT201700566T1 (https=)
UA (2) UA128302C2 (https=)
WO (1) WO2011057788A1 (https=)
ZA (1) ZA201202418B (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6358588A (ja) * 1986-08-29 1988-03-14 Toshiba Corp バ−コ−ドèȘ­ć–èŁ…çœź
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
US12492253B1 (en) * 2008-02-25 2025-12-09 Xencor, Inc. Anti-human C5 antibodies
SMT202300421T1 (it) 2009-02-20 2024-01-10 Astellas Pharma Inc Metodi e composizioni per la diagnosi e il trattamento del cancro
DK3305813T3 (da) 2009-11-11 2020-04-20 Astellas Pharma Inc Antistoffer, der er specifikke for claudin 6 (cldn6)
EP2404936A1 (en) 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
PT3434767T (pt) 2010-11-30 2026-01-23 Chugai Pharmaceutical Co Ltd Agente terapĂȘutico indutor de citotoxicidade
SG10201911551RA (en) * 2011-05-13 2020-02-27 Ganymed Pharmaceuticals Gmbh Antibodies for treatment of cancer expressing claudin 6
ES2989943T3 (es) * 2011-05-13 2024-11-28 Astellas Pharma Inc Anticuerpos para el tratamiento de un cĂĄncer que expresa la Claudina 6
CN103320381B (zh) * 2012-03-23 2015-04-15 äžŠæ”·ćž‚ć„żç«„ćŒ»é™ą äž€ç§ć€šèƒœćčČç»†èƒžèĄšéąæ ‡ćż—ç‰©ćŠć…¶ç”šé€”
ES2702315T3 (es) 2012-08-24 2019-02-28 Univ California Anticuerpos y vacunas para su uso en tratar cĂĄnceres ROR1 e inhibir metĂĄstasis
JP6499079B2 (ja) * 2012-11-13 2019-04-10 ăƒă‚€ă‚Șスヌテック ă‚ąăƒŒă‚ČăƒŒïŒąïœ‰ïœïŒźïŒŽïœ…ïœƒïœˆ ïŒĄïŒ§ ă‚Żăƒ­ăƒŒăƒ‡ă‚Łăƒłă‚’ç™șçŸă™ă‚‹ă‚Źăƒłç–Ÿæ‚Łă‚’ć‡Šçœźă™ă‚‹ăŸă‚ăźć‰€
EP3766903A3 (en) * 2012-11-13 2021-02-17 BioNTech SE Bispecific anti claudin xcd3 antibodies for treatment of claudin expressing cancer diseases
EP3738611B1 (en) * 2013-07-31 2025-09-03 BioNTech SE Diagnosis and therapy of cancer involving cancer stem cells
WO2015014376A1 (en) * 2013-07-31 2015-02-05 Biontech Ag Diagnosis and therapy of cancer involving cancer stem cells
RU2016122041A (ru) * 2013-11-06 2017-12-11 ЭББВИ СбЕМСЕНбРКС ЭлЭлХО ĐĐŸĐČŃ‹Đ” Đ°ĐœŃ‚Đž-ĐșĐ»Đ°ŃƒĐŽĐžĐœ Đ°ĐœŃ‚ĐžŃ‚Đ”Đ»Đ° Đž ŃĐżĐŸŃĐŸĐ±Ń‹ ох ĐżŃ€ĐžĐŒĐ”ĐœĐ”ĐœĐžŃ
KR102813659B1 (ko) 2013-11-11 2025-05-28 추가읎 ì„žìŽì•Œìż  가부시킀가읎샀 ê°œëł€ëœ 항ìČŽ ê°€ëł€ì˜ì—­ì„ 포핹하는 항원 êČ°í•© 분자
PT3514172T (pt) * 2014-04-01 2020-04-21 Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh Imunorrecetores específicos de claudina-6 e epítopos de células t
MA40921A (fr) * 2014-11-05 2017-09-12 Abbvie Stemcentrx Llc Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation
TWI831044B (zh) 2014-11-11 2024-02-01 æ—„ć•†äž­ć€–èŁœè—„è‚Ąä»œæœ‰é™ć…Źćž æŠ—ćŽŸç”ćˆćˆ†ć­ă€ćŒ…ć«æŠ—ćŽŸç”ćˆćˆ†ć­çš„é†«è—„ç”„ćˆç‰©ä»„ćŠèŁœé€ ćŠéžæ“‡æŠ—ćŽŸç”ćˆćˆ†ć­äč‹æ–čæł•
TWI767915B (zh) 2016-06-27 2022-06-21 ćŠ ć·žć€§ć­žè‘Łäș‹æœƒ Ror-1與btkæ‹źæŠ—ćŠ‘çš„ç”„ćˆ
WO2018105560A1 (ja) * 2016-12-07 2018-06-14 ć›œç«‹ć€§ć­Šæł•äșș性é˜Ș性歊 ïŒŁïœŒïœïœ•ïœ„ïœ‰ïœŽ ïŒ•æŠ—äœ“ă€ćŠăłăăźæŠ—äœ“ă‚’ć«æœ‰ă™ă‚‹ćŒ»è–Ź
US11053313B2 (en) 2017-05-08 2021-07-06 Osaka University Anti-CLDN-5 antibody, and drug containing said antibody
WO2019048040A1 (en) 2017-09-06 2019-03-14 Ganymed Pharmaceuticals Gmbh ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER
NZ762505A (en) 2017-09-29 2026-03-27 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
TW201938194A (zh) 2017-12-05 2019-10-01 æ—„ć•†äž­ć€–èŁœè—„è‚Ąä»œæœ‰é™ć…Źćž ćŒ…ć«ç”ćˆcd3揊cd137的æ”čèźŠçš„æŠ—é«”ćŻèźŠć€äč‹æŠ—ćŽŸç”ćˆćˆ†ć­
US20210054076A1 (en) * 2018-01-05 2021-02-25 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
JP7374499B2 (ja) * 2018-10-09 2023-11-07 ć…Źç«‹ć€§ć­Šæł•äșșçŠćł¶çœŒç«‹ćŒ»ç§‘ć€§ć­Š ć­ćźźäœ“ç™Œæ‚Łè€…ăźäșˆćŸŒäșˆæžŹăƒă‚€ă‚ȘăƒžăƒŒă‚«ăƒŒ
MA54955A (fr) 2019-02-15 2021-12-22 Integral Molecular Inc Anticorps anti-claudine 6 et leurs utilisations
DK3941946T3 (da) 2019-03-20 2025-03-24 Univ California Claudin-6-antistoffer og lĂŠgemiddelkonjugater
CN113631229B (zh) 2019-03-25 2025-09-23 珏䞀䞉慱æ ȘćŒäŒšç€Ÿ æŠ—äœ“ïŒćĄć’Żćč¶è‹Żćč¶äșŒæ°źæ‚ć“èĄç”Ÿç‰©ć¶è”ç‰©
MX2022000111A (es) 2019-07-10 2022-02-10 Chugai Pharmaceutical Co Ltd Moleculas de union a claudina-6 y usos de las mismas.
CN111087465B (zh) * 2019-12-24 2020-12-08 ćčżć·žćŒ»ç§‘性歊 侀种针ćŻčćŻ†è›‹ç™œ6çš„æŠ—äœ“ć¶è”èŻç‰©ćŠćș”甚
CA3174094A1 (en) 2020-03-31 2021-10-07 Shinya Ishii Claudin-6 targeting multispecific antigen-binding molecules and uses thereof
KR20230154317A (ko) * 2021-03-05 2023-11-07 상하읎 ì  ëČ ìŽìŠ€ ë°”ìŽì˜€í…ŒíŹë†€ëĄœì§€ 씚였., 엘티디. 항-cldn6 항ìČŽ 및 읎의 용도
US11739144B2 (en) 2021-03-09 2023-08-29 Xencor, Inc. Heterodimeric antibodies that bind CD3 and CLDN6
WO2023053282A1 (ja) 2021-09-29 2023-04-06 äž­ć€–èŁœè–Źæ ȘćŒäŒšç€Ÿ がんぼæČ»ç™‚ă«ç”šă„ă‚‹ăŸă‚ăźçŽ°èƒžć‚·ćźłèȘ˜ć°ŽæȻ療所
US20260027209A1 (en) * 2022-07-29 2026-01-29 Legend Biotech Ireland Limited Claudin-6 binding moieties and uses thereof
AU2023373601A1 (en) 2022-10-31 2025-04-03 Astellas Pharma Inc. Antibody-drug conjugate containing a toll-like receptor 7/8 dual agonist compound
TW202430574A (zh) 2022-11-30 2024-08-01 çŸŽć•†ç©ćˆ†ćˆ†ć­è‚Ąä»œæœ‰é™ć…Źćž é‡ć°ćŻ†é€Łè›‹ç™œïŒ–äč‹æŠ—é«”ïŒŒćŒ…æ‹Źć…¶é›™ç‰čç•°æ€§æ ŒćŒ
CN116064622B (zh) * 2023-02-13 2023-10-13 äŒ˜çżè”›æ€(歊汉)ç”Ÿç‰©ç§‘æŠ€æœ‰é™ć…Źćž Claudin6-mCherryæŠ„ć‘ŠćŸș曠CHO-K1çšłèœŹç»†èƒžæ Șćˆ¶ć€‡ćŠćș”甚
WO2024235175A1 (zh) * 2023-05-12 2024-11-21 æ™șæłœç«„ćș·(ćčżć·ž)ç”Ÿç‰©ç§‘æŠ€æœ‰é™ć…Źćž 抗cldn6æŠ—äœ“ćŠć…¶ç”šé€”
IL324834A (en) 2023-05-25 2026-01-01 Univ California Dosage of claudin-6 conjugates for cancer treatment
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
CN119371534B (zh) * 2024-08-21 2025-05-27 ç™Ÿć‰ç”Ÿç‰©ćŒ»èŻ(ćčżć·ž)è‚Ąä»œæœ‰é™ć…Źćž äž€ç§çŽ§ćŻ†èżžæŽ„è›‹ç™œæŠ—äœ“e02ćŠć…¶ćș”甚
CN118754987B (zh) * 2024-08-21 2025-02-11 ćčżć·žç™Ÿć‰ç”Ÿç‰©ćˆ¶èŻæœ‰é™ć…Źćž äž€ç§çŽ§ćŻ†èżžæŽ„è›‹ç™œæŠ—äœ“h04ćŠć…¶ćș”甚
CN119320451B (zh) * 2024-08-21 2025-05-16 ç™Ÿć‰ç”Ÿç‰©ćŒ»èŻ(ćčżć·ž)è‚Ąä»œæœ‰é™ć…Źćž äž€ç§çŽ§ćŻ†èżžæŽ„è›‹ç™œæŠ—äœ“d03ćŠć…¶ćș”甚
WO2026084392A1 (ko) * 2024-10-14 2026-04-23 에읎ëč„엘바읎였 ìŁŒì‹íšŒì‚Ź 항-큎띌우딘6 항ìČŽ 및 읎의 용도

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
JP3101690B2 (ja) 1987-03-18 2000-10-23 スă‚čăƒ»ăƒ“ă‚Łăƒ»ïŒ’ăƒ»ă‚€ăƒłă‚łăƒŒăƒăƒŹă‚€ăƒ†ăƒƒăƒ‰ ć€‰æ€§æŠ—äœ“ăźă€ăŸăŸăŻć€‰æ€§æŠ—äœ“ă«é–ąă™ă‚‹æ”čè‰Ż
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
GB9019812D0 (en) 1990-09-11 1990-10-24 Scotgen Ltd Novel antibodies for treatment and prevention of infection in animals and man
US5830755A (en) 1995-03-27 1998-11-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services T-cell receptors and their use in therapeutic and diagnostic methods
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5677139A (en) 1995-04-21 1997-10-14 President And Fellows Of Harvard College In vitro differentiation of CD34+ progenitor cells into T lymphocytes
UA56132C2 (uk) 1995-04-25 2003-05-15 ĐĄĐŒŃ–Ń‚ĐșлаĐčĐœ Đ‘Ń–Ń‡Đ”ĐŒ БаĐčĐŸĐ»ĐŸĐŽĐ¶Ń–Đșалс ĐĄ.А. ĐšĐŸĐŒĐżĐŸĐ·ĐžŃ†Ń–Ń ĐČĐ°ĐșŃ†ĐžĐœĐž (ĐČĐ°Ń€Ń–Đ°ĐœŃ‚Đž), ŃĐżĐŸŃŃ–Đ± стабілізації qs21 ĐČŃ–ĐŽĐœĐŸŃĐœĐŸ ĐłŃ–ĐŽŃ€ĐŸĐ»Ń–Đ·Ńƒ (ĐČĐ°Ń€Ń–Đ°ĐœŃ‚Đž), ŃĐżĐŸŃŃ–Đ± ĐżŃ€ĐžĐłĐŸŃ‚ŃƒĐČĐ°ĐœĐœŃ ĐșĐŸĐŒĐżĐŸĐ·ĐžŃ†Ń–Ń— ĐČĐ°ĐșŃ†ĐžĐœĐž
WO2002000690A2 (en) 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
WO2000073348A2 (en) 1999-06-02 2000-12-07 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
WO2002008284A2 (en) 2000-07-20 2002-01-31 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
WO2000078961A1 (en) 1999-06-23 2000-12-28 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US5928631A (en) 1997-06-09 1999-07-27 The Procter & Gamble Company Methods for controlling environmental odors on the body using compositions comprising uncomplexed cyclodextrins
US20020127584A1 (en) 1997-09-18 2002-09-12 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US5932445A (en) 1997-11-07 1999-08-03 Incyte Pharmaceuticals, Inc. Signal peptide-containing proteins
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
NZ531664A (en) 1998-09-01 2005-07-29 Genentech Inc Pro1317 polypeptides and sequences thereof with homology to the semaphorin B glycoprotein family
AU773028B2 (en) * 1998-11-03 2004-05-13 Adherex Technologies Inc. Compounds and methods for modulating claudin-mediated functions
AU3124000A (en) 1998-12-17 2000-07-03 Human Genome Sciences, Inc. 47 human secreted proteins
JP2002536995A (ja) 1999-02-22 2002-11-05 ă‚€ăƒłă‚”ă‚€ăƒˆăƒ»ăƒ•ă‚ĄăƒŒăƒžă‚čăƒŒăƒ†ă‚Łă‚«ăƒ«ă‚șăƒ»ă‚€ăƒłă‚łăƒŒăƒăƒŹă‚€ăƒ†ăƒƒăƒ‰ ç”è…žăźç–Ÿæ‚Łă«é–ąé€Łă™ă‚‹éșäŒć­
EP1514933A1 (en) 1999-07-08 2005-03-16 Research Association for Biotechnology Secretory protein or membrane protein
KR20020027490A (ko) * 1999-07-12 2002-04-13 ì œë„ší…ŒíŹ, ìžíŹ. ïŒŁïœ„20에 êČ°í•©í•˜ëŠ” Ꞟ항제넌 ì‚Źìš©í•œ 왞래 항원에 대한멎역 반응 ì°šë‹š ë°©ëȕ
CA2402563A1 (en) 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
AU2001236470A1 (en) 2000-01-14 2001-07-24 Corixa Corporation Ovarian tumor-associated sequences
ES2336887T5 (es) 2000-03-30 2019-03-06 Whitehead Inst Biomedical Res Mediadores de interferencia por ARN especĂ­ficos de secuencias de ARN
AU6531101A (en) 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU2001273150A1 (en) 2000-07-20 2002-02-05 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EA013564B1 (ru) 2000-08-03 2010-06-30 ĐąĐ”Ń€Đ°ĐżĐ”ŃƒŃ‚ĐžĐș Đ„ŃŒŃŽĐŒĐ°Đœ ĐŸĐŸĐ»ĐžĐșĐ»ĐŸĐœĐ°Đ»Đ· Đ˜ĐœĐș. Đ“ŃƒĐŒĐ°ĐœĐžĐ·ĐžŃ€ĐŸĐČĐ°ĐœĐœŃ‹Đč ĐžĐŒĐŒŃƒĐœĐŸĐłĐ»ĐŸĐ±ŃƒĐ»ĐžĐœ Đž ŃĐŸĐŽĐ”Ń€Đ¶Đ°Ń‰Đ°Ń Đ”ĐłĐŸ Ń„Đ°Ń€ĐŒĐ°Ń†Đ”ĐČтОчДсĐșая ĐșĐŸĐŒĐżĐŸĐ·ĐžŃ†ĐžŃ
CA2430013C (en) 2000-11-30 2011-11-22 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
PT2000545E (pt) 2001-06-20 2011-12-21 Genentech Inc ComposiçÔes e métodos para o diagnóstico e tratamento do tumor pulmonar
CA2450793A1 (en) * 2001-06-20 2002-12-27 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
CA2379661A1 (en) * 2002-03-28 2003-09-28 Kursad Turksen Paracellular drug delivery system
JP2005536190A (ja) 2002-04-16 2005-12-02 ă‚žă‚§ăƒăƒłăƒ†ăƒƒă‚Żăƒ»ă‚€ăƒłă‚łăƒŒăƒăƒŹăƒŒăƒ†ăƒƒăƒ‰ è…«ç˜ăźèšșæ–­ăšæČ»ç™‚ăźăŸă‚ăźç”„æˆç‰©ăšæ–čæł•
AU2003295328A1 (en) 2002-10-02 2004-04-23 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
BRPI0315295C1 (pt) 2002-10-17 2021-05-25 Genmab As anticorpo monoclonal humano isolado, cĂ©lula hospedeira procariĂłtica, composição farmacĂȘutica, molĂ©cula biespecĂ­fica, usos de um anticorpo, mĂ©todos in vitro de detectar a presença de antĂ­geno de cd20 ou uma cĂ©lula que expressa cd20 em uma amostra, kit, e, vetor de expressĂŁo
AU2003303144A1 (en) 2002-10-18 2004-07-29 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
AT500651B9 (de) 2003-05-27 2010-04-15 Altropus Gmbh Aktiv immunisierender antikörper
US20060019256A1 (en) 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
WO2006033664A1 (en) 2004-03-08 2006-03-30 Avalon Pharmaceuticals Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
ITRM20050297A1 (it) * 2005-06-08 2006-12-09 Univ Siena Anticorpi diretti contro la proteina basica della mielina che riconoscono un epitopo del cd64 e uso di essi come immunodepressivi.
NZ612578A (en) 2005-08-19 2014-11-28 Abbvie Inc Dual variable domain immunoglobin and uses thereof
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
MX2009003306A (es) * 2006-10-02 2009-04-23 Medarex Inc Anticuerpos humanos que se unen a cxcr4 y sus usos.
WO2008058379A1 (en) * 2006-11-13 2008-05-22 Arius Research Inc. Cancerous disease modifying antibodies
JPWO2008114733A1 (ja) 2007-03-16 2010-07-01 捔撌ç™ș酔キăƒȘンæ ȘćŒäŒšç€Ÿ æŠ—ïŒŁïœŒïœïœ•ïœ„ïœ‰ïœŽâˆ’ïŒ”æŠ—äœ“
EP1997832A1 (en) 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Monoclonal antibodies against Claudin-18 for treatment of cancer
WO2009025759A1 (en) * 2007-08-17 2009-02-26 Progenics Pharmaceuticals (Nevada), Inc. Tight junction proteins associated with infection and entry of hepatitis c virus (hcv), methods and uses thereof
WO2009028663A1 (ja) 2007-08-30 2009-03-05 Kyowa Hakko Kirin Co., Ltd. 抗Claudin-3抗䜓
EP2060583A1 (en) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identification of tumor-associated markers for diagnosis and therapy
EP2241578B1 (en) * 2008-01-11 2016-04-20 The University of Tokyo Anti-cldn6 antibody
AU2009234259A1 (en) 2008-04-11 2009-10-15 Bionovo, Inc. Anticancer methods employing extracts of Gleditsia sinensis Lam
US9005963B2 (en) 2008-10-14 2015-04-14 Ablynx N.V. Amino acid sequences directed against cellular receptors for viruses and bacteria
DE102009026966A1 (de) 2008-12-18 2010-07-01 Robert Bosch Gmbh Betrieb eines BremskraftverstÀrkers als Pedalsimulator
SMT202300421T1 (it) 2009-02-20 2024-01-10 Astellas Pharma Inc Metodi e composizioni per la diagnosi e il trattamento del cancro
EP2221063A1 (en) 2009-02-20 2010-08-25 Ganymed Pharmaceuticals AG Methods and compositions for diagnosis and treatment of cancer
DK3305813T3 (da) 2009-11-11 2020-04-20 Astellas Pharma Inc Antistoffer, der er specifikke for claudin 6 (cldn6)
EP2322555A1 (en) 2009-11-11 2011-05-18 Ganymed Pharmaceuticals AG Antibodies specific for claudin 6 (CLDN6)
EP2404936A1 (en) 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
ES2989943T3 (es) 2011-05-13 2024-11-28 Astellas Pharma Inc Anticuerpos para el tratamiento de un cĂĄncer que expresa la Claudina 6
EP2605017A1 (de) 2011-12-16 2013-06-19 Protagen AG Markersequenzen fĂŒr gynĂ€kologisches Malignom und deren Verwendung
EP2875046B2 (en) 2012-07-19 2025-04-30 Amgen Inc. Human btnl3 proteins, nucleic acids, and antibodies and uses thereof
JP6499079B2 (ja) * 2012-11-13 2019-04-10 ăƒă‚€ă‚Șスヌテック ă‚ąăƒŒă‚ČăƒŒïŒąïœ‰ïœïŒźïŒŽïœ…ïœƒïœˆ ïŒĄïŒ§ ă‚Żăƒ­ăƒŒăƒ‡ă‚Łăƒłă‚’ç™șçŸă™ă‚‹ă‚Źăƒłç–Ÿæ‚Łă‚’ć‡Šçœźă™ă‚‹ăŸă‚ăźć‰€
PT3514172T (pt) * 2014-04-01 2020-04-21 Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh Imunorrecetores específicos de claudina-6 e epítopos de células t

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