ZA201006589B - Bridged heterocycles as hiv integrase inhibitors - Google Patents

Bridged heterocycles as hiv integrase inhibitors

Info

Publication number
ZA201006589B
ZA201006589B ZA2010/06589A ZA201006589A ZA201006589B ZA 201006589 B ZA201006589 B ZA 201006589B ZA 2010/06589 A ZA2010/06589 A ZA 2010/06589A ZA 201006589 A ZA201006589 A ZA 201006589A ZA 201006589 B ZA201006589 B ZA 201006589B
Authority
ZA
South Africa
Prior art keywords
hiv integrase
integrase inhibitors
bridged heterocycles
heterocycles
bridged
Prior art date
Application number
ZA2010/06589A
Other languages
English (en)
Inventor
Francis Beaulieu
Carl Ouellet
B Narasimhulu Naidu
Manoj Patel
Yasutsugu Ueda
Timothy P Connolly
Jonathan R Weiss
Michael A Walker
Nicholas A Meanwell
Kevin M Peese
Margaret E Sorenson
Chen Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA201006589B publication Critical patent/ZA201006589B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA2010/06589A 2008-03-19 2010-09-14 Bridged heterocycles as hiv integrase inhibitors ZA201006589B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3772908P 2008-03-19 2008-03-19
US12/406,268 US8129398B2 (en) 2008-03-19 2009-03-18 HIV integrase inhibitors
PCT/US2009/037596 WO2009117540A1 (en) 2008-03-19 2009-03-19 Bridged heterocycles as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
ZA201006589B true ZA201006589B (en) 2012-02-29

Family

ID=40863725

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2010/06589A ZA201006589B (en) 2008-03-19 2010-09-14 Bridged heterocycles as hiv integrase inhibitors

Country Status (15)

Country Link
US (1) US8129398B2 (https=)
EP (1) EP2280981B8 (https=)
JP (1) JP2011515412A (https=)
KR (1) KR20100137522A (https=)
CN (1) CN102036996A (https=)
AU (1) AU2009225577A1 (https=)
BR (1) BRPI0910307A2 (https=)
CA (1) CA2718950A1 (https=)
CO (1) CO6331439A2 (https=)
EA (1) EA201001508A1 (https=)
IL (1) IL208068A0 (https=)
MX (1) MX2010009995A (https=)
NZ (1) NZ588031A (https=)
WO (1) WO2009117540A1 (https=)
ZA (1) ZA201006589B (https=)

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US8383639B2 (en) 2009-10-15 2013-02-26 Bristol-Myers Squibb Company HIV integrase inhibitors
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US8846659B2 (en) 2010-12-10 2014-09-30 Bristol-Myers Squibb Company HIV integrase inhibitors
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US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
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US8906929B2 (en) * 2012-08-16 2014-12-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
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CN103601613B (zh) * 2013-11-19 2015-07-08 浙江林江化工股份有限公司 一种3,4,5-三氟溴苯的制备方法
WO2015096651A1 (en) 2013-12-23 2015-07-02 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
EP3139930B1 (en) 2014-05-05 2024-08-14 Melinta Therapeutics, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
ES2750805T3 (es) 2014-05-05 2020-03-27 Rempex Pharmaceuticals Inc Síntesis de sales de boronato y usos de las mismas
AU2015264418A1 (en) 2014-05-19 2016-11-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
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TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
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US10662205B2 (en) 2014-11-18 2020-05-26 Qpex Biopharma, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
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US10647727B2 (en) 2015-06-25 2020-05-12 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
WO2017000277A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
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IL295677B1 (en) 2020-02-24 2026-04-01 Gilead Sciences Inc Tetracyclic compounds for the treatment of HIV infection
AU2021266715A1 (en) 2020-05-05 2022-11-17 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof
CA3192145A1 (en) 2020-09-30 2022-04-07 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
FI4196479T3 (fi) 2021-01-19 2024-01-17 Gilead Sciences Inc Substituoituja pyridotriatsiiniyhdisteitä ja niiden käyttöjä
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Also Published As

Publication number Publication date
EP2280981B1 (en) 2014-04-23
EA201001508A1 (ru) 2011-04-29
MX2010009995A (es) 2010-09-30
EP2280981A1 (en) 2011-02-09
CN102036996A (zh) 2011-04-27
CO6331439A2 (es) 2011-10-20
NZ588031A (en) 2011-12-22
US20090253677A1 (en) 2009-10-08
AU2009225577A1 (en) 2009-09-24
KR20100137522A (ko) 2010-12-30
IL208068A0 (en) 2010-12-30
WO2009117540A1 (en) 2009-09-24
JP2011515412A (ja) 2011-05-19
CA2718950A1 (en) 2009-09-24
BRPI0910307A2 (pt) 2019-09-24
US8129398B2 (en) 2012-03-06
EP2280981B8 (en) 2014-09-17

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