CO6331439A2 - 1-2 bicíclicos pirimidinona carboxamida como inhibidores de la integrasa del virus de inmunodeficiencia humana - Google Patents

1-2 bicíclicos pirimidinona carboxamida como inhibidores de la integrasa del virus de inmunodeficiencia humana

Info

Publication number
CO6331439A2
CO6331439A2 CO10115016A CO10115016A CO6331439A2 CO 6331439 A2 CO6331439 A2 CO 6331439A2 CO 10115016 A CO10115016 A CO 10115016A CO 10115016 A CO10115016 A CO 10115016A CO 6331439 A2 CO6331439 A2 CO 6331439A2
Authority
CO
Colombia
Prior art keywords
pirimidinona
integress
carboxamida
bicycles
inhibitors
Prior art date
Application number
CO10115016A
Other languages
English (en)
Inventor
Francis Beaulieu
Carl Ouellet
B Narasimhulu Naidu
Manoj Patel
Yasutsugu Ueda
Timothy P Connolly
Jonathan Weiss
Michael A Walker
Nicholas A Meanwell
Kevin Peese
Margaret E Sorenson
Li Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO6331439A2 publication Critical patent/CO6331439A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems

Abstract

La invención se refiere generalmente a los nuevos compuestos de la fórmula I,incluyendo sus sales, los cuales inhiben VIH integrasa e impiden la integración viral en ADN humano. Esta acción hace a los compuestos útiles para tratar infección por VIH y SIDA. La invención abarca también composiciones farmacéuticas y métodos para tratar a aquellos infectados con VIH.
CO10115016A 2008-03-19 2010-09-16 1-2 bicíclicos pirimidinona carboxamida como inhibidores de la integrasa del virus de inmunodeficiencia humana CO6331439A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3772908P 2008-03-19 2008-03-19
US12/406,268 US8129398B2 (en) 2008-03-19 2009-03-18 HIV integrase inhibitors

Publications (1)

Publication Number Publication Date
CO6331439A2 true CO6331439A2 (es) 2011-10-20

Family

ID=40863725

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10115016A CO6331439A2 (es) 2008-03-19 2010-09-16 1-2 bicíclicos pirimidinona carboxamida como inhibidores de la integrasa del virus de inmunodeficiencia humana

Country Status (15)

Country Link
US (1) US8129398B2 (es)
EP (1) EP2280981B8 (es)
JP (1) JP2011515412A (es)
KR (1) KR20100137522A (es)
CN (1) CN102036996A (es)
AU (1) AU2009225577A1 (es)
BR (1) BRPI0910307A2 (es)
CA (1) CA2718950A1 (es)
CO (1) CO6331439A2 (es)
EA (1) EA201001508A1 (es)
IL (1) IL208068A0 (es)
MX (1) MX2010009995A (es)
NZ (1) NZ588031A (es)
WO (1) WO2009117540A1 (es)
ZA (1) ZA201006589B (es)

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CN103601613B (zh) * 2013-11-19 2015-07-08 浙江林江化工股份有限公司 一种3,4,5-三氟溴苯的制备方法
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WO2015171398A1 (en) 2014-05-05 2015-11-12 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
JP6672176B2 (ja) 2014-05-19 2020-03-25 レンペックス・ファーマシューティカルズ・インコーポレイテッド ボロン酸誘導体およびその治療的使用
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
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Also Published As

Publication number Publication date
JP2011515412A (ja) 2011-05-19
EP2280981B8 (en) 2014-09-17
IL208068A0 (en) 2010-12-30
ZA201006589B (en) 2012-02-29
US20090253677A1 (en) 2009-10-08
EP2280981A1 (en) 2011-02-09
EP2280981B1 (en) 2014-04-23
CA2718950A1 (en) 2009-09-24
EA201001508A1 (ru) 2011-04-29
KR20100137522A (ko) 2010-12-30
BRPI0910307A2 (pt) 2019-09-24
AU2009225577A1 (en) 2009-09-24
MX2010009995A (es) 2010-09-30
WO2009117540A1 (en) 2009-09-24
CN102036996A (zh) 2011-04-27
US8129398B2 (en) 2012-03-06
NZ588031A (en) 2011-12-22

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