ZA200908342B - Methods and compositions for the specific inhibition of gene expression by double-stranded RNA - Google Patents
Methods and compositions for the specific inhibition of gene expression by double-stranded RNAInfo
- Publication number
- ZA200908342B ZA200908342B ZA200908342A ZA200908342A ZA200908342B ZA 200908342 B ZA200908342 B ZA 200908342B ZA 200908342 A ZA200908342 A ZA 200908342A ZA 200908342 A ZA200908342 A ZA 200908342A ZA 200908342 B ZA200908342 B ZA 200908342B
- Authority
- ZA
- South Africa
- Prior art keywords
- compositions
- double
- methods
- gene expression
- stranded rna
- Prior art date
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 title 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/33—Chemical structure of the base
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/53—Physical structure partially self-complementary or closed
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- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
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- C12N2320/00—Applications; Uses
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/797,216 US20070265220A1 (en) | 2004-03-15 | 2007-05-01 | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200908342B true ZA200908342B (en) | 2010-08-25 |
Family
ID=39944357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200908342A ZA200908342B (en) | 2007-05-01 | 2009-11-25 | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
Country Status (9)
| Country | Link |
|---|---|
| US (11) | US20070265220A1 (OSRAM) |
| EP (1) | EP2155772A4 (OSRAM) |
| JP (1) | JP2010525813A (OSRAM) |
| CN (1) | CN101848923A (OSRAM) |
| AU (1) | AU2008246307A1 (OSRAM) |
| BR (1) | BRPI0811475A2 (OSRAM) |
| CA (1) | CA2685453A1 (OSRAM) |
| WO (1) | WO2008136902A1 (OSRAM) |
| ZA (1) | ZA200908342B (OSRAM) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL166546A0 (en) | 2002-08-05 | 2006-01-15 | Atugen Ag | Further novel forms of interfering ran molecules |
| US7892793B2 (en) * | 2002-11-04 | 2011-02-22 | University Of Massachusetts | Allele-specific RNA interference |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| CA2528012C (en) | 2003-06-02 | 2015-11-24 | University Of Massachusetts | Methods and compositions for controlling efficacy of rna silencing |
| US8309704B2 (en) * | 2003-06-02 | 2012-11-13 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNAi |
| US8680063B2 (en) * | 2003-09-12 | 2014-03-25 | University Of Massachusetts | RNA interference for the treatment of gain-of-function disorders |
| EP1670518B1 (en) * | 2003-09-12 | 2014-05-21 | University of Massachusetts | Rna interference for the treatment of gain-of-function disorders |
| US20060134787A1 (en) * | 2004-12-22 | 2006-06-22 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| WO2005089287A2 (en) | 2004-03-15 | 2005-09-29 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
| EP2239328A3 (en) * | 2005-08-18 | 2011-01-05 | Alnylam Pharmaceuticals Inc. | Methods and compositions for treating neurological disease |
| AU2007283022B2 (en) | 2006-08-08 | 2011-07-28 | Rheinische Friedrich-Wilhelms-Universitat Bonn | Structure and use of 5' phosphate oligonucleotides |
| WO2008143774A2 (en) * | 2007-05-01 | 2008-11-27 | University Of Massachusetts | Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy |
| WO2009141146A1 (en) | 2008-05-21 | 2009-11-26 | Gunther Hartmann | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| TWI455944B (zh) * | 2008-07-01 | 2014-10-11 | Daiichi Sankyo Co Ltd | 雙股多核苷酸 |
| EP2323695B1 (en) | 2008-08-19 | 2018-12-05 | Nektar Therapeutics | Complexes of small-interfering nucleic acids |
| US8225729B2 (en) * | 2008-12-16 | 2012-07-24 | Kimberly-Clark Worldwide, Inc. | Three-dimensional wiping substrate and method therefor |
| US11408003B2 (en) | 2008-12-18 | 2022-08-09 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| WO2010080129A2 (en) * | 2008-12-18 | 2010-07-15 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| WO2010093788A2 (en) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Multiplex dicer substrate rna interference molecules having joining sequences |
| US20120022142A1 (en) * | 2009-03-27 | 2012-01-26 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| CA2757613C (en) * | 2009-04-03 | 2023-10-17 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of kras by asymmetric double-stranded rna |
| EP2756845B1 (en) * | 2009-04-03 | 2017-03-15 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA |
| US20120114710A1 (en) * | 2009-05-18 | 2012-05-10 | Lynn Kirkpatrick | Carbon nanotubes complexed with multiple bioactive agents and methods related thereto |
| WO2010141933A1 (en) * | 2009-06-05 | 2010-12-09 | Dicerna Pharmaceuticals, Inc. | Specific inhibition of gene expression by nucleic acid containing a dicer substrate |
| EP2440666B1 (en) | 2009-06-10 | 2017-03-01 | Temasek Life Sciences Laboratory Limited | Virus induced gene silencing (vigs) for functional analysis of genes in cotton |
| CA2767127A1 (en) | 2009-07-01 | 2011-01-06 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for delivery of therapeutic agents to solid tumors |
| US8716464B2 (en) | 2009-07-20 | 2014-05-06 | Thomas W. Geisbert | Compositions and methods for silencing Ebola virus gene expression |
| WO2011035065A1 (en) | 2009-09-17 | 2011-03-24 | Nektar Therapeutics | Monoconjugated chitosans as delivery agents for small interfering nucleic acids |
| CA2775092A1 (en) | 2009-09-23 | 2011-03-31 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing genes expressed in cancer |
| WO2011072082A2 (en) | 2009-12-09 | 2011-06-16 | Nitto Denko Corporation | Modulation of hsp47 expression |
| WO2011072292A2 (en) * | 2009-12-11 | 2011-06-16 | Dicerna Pharmaceuticals, Inc. | Phase changing formulations of rna and rna derivatives |
| JP5257796B2 (ja) * | 2009-12-28 | 2013-08-07 | 株式会社村田製作所 | 固体電解コンデンサ素子及びその製造方法 |
| PT3587579T (pt) | 2010-07-06 | 2021-05-24 | Dicerna Pharmaceuticals Inc | Métodos e composições para a inibição específica de beta-catenina por rna de filamento duplo |
| WO2012006241A2 (en) | 2010-07-06 | 2012-01-12 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna |
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| EP2622064B1 (en) | 2010-10-01 | 2019-05-29 | Modernatx, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| US20140134231A1 (en) | 2010-10-11 | 2014-05-15 | Sanford-Burnham Medical Research Institute | Mir-211 expression and related pathways in human melanoma |
| WO2012056440A1 (en) * | 2010-10-28 | 2012-05-03 | Nanodoc Ltd. | COMPOSITIONS AND METHODS FOR ACTIVATING EXPRESSION BY A SPECIFIC ENDOGENOUS miRNA |
| KR101937498B1 (ko) | 2011-03-03 | 2019-04-10 | 쿠아크 파마수티칼스 인코퍼레이티드 | 폐 질환 및 손상을 치료하기 위한 조성물 및 방법 |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| US8710200B2 (en) | 2011-03-31 | 2014-04-29 | Moderna Therapeutics, Inc. | Engineered nucleic acids encoding a modified erythropoietin and their expression |
| SG195304A1 (en) | 2011-06-10 | 2013-12-30 | Temasek Life Sciences Lab Ltd | Genetic manipulation and expression systems for pucciniomycotina and ustilaginomycotina subphyla |
| WO2012173994A2 (en) * | 2011-06-15 | 2012-12-20 | Dicerna Pharmaceuticals, Inc. | Phase changing formulations of nucleic acid payloads |
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| EP3492109B1 (en) | 2011-10-03 | 2020-03-04 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| CN103987847B (zh) | 2011-10-18 | 2017-06-16 | 迪克纳制药公司 | 胺阳离子脂质及其用途 |
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