ZA200904676B - Modulators of sclerostin binding partners for treating bonerelated disorders - Google Patents
Modulators of sclerostin binding partners for treating bonerelated disordersInfo
- Publication number
- ZA200904676B ZA200904676B ZA200904676A ZA200904676A ZA200904676B ZA 200904676 B ZA200904676 B ZA 200904676B ZA 200904676 A ZA200904676 A ZA 200904676A ZA 200904676 A ZA200904676 A ZA 200904676A ZA 200904676 B ZA200904676 B ZA 200904676B
- Authority
- ZA
- South Africa
- Prior art keywords
- bonerelated
- modulators
- disorders
- treating
- binding partners
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2310/14—Type of nucleic acid interfering N.A.
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88795607P | 2007-02-02 | 2007-02-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200904676B true ZA200904676B (en) | 2010-04-28 |
Family
ID=39298321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200904676A ZA200904676B (en) | 2007-02-02 | 2009-07-03 | Modulators of sclerostin binding partners for treating bonerelated disorders |
Country Status (16)
Country | Link |
---|---|
US (3) | US20100028335A1 (fr) |
EP (1) | EP2114435A1 (fr) |
JP (1) | JP2010526766A (fr) |
KR (1) | KR20090115133A (fr) |
CN (1) | CN101616684A (fr) |
AU (1) | AU2008209713B2 (fr) |
BR (1) | BRPI0807205A2 (fr) |
CA (1) | CA2675639A1 (fr) |
EA (1) | EA200901031A1 (fr) |
IL (1) | IL199834A0 (fr) |
MA (1) | MA31156B1 (fr) |
MX (1) | MX2009008096A (fr) |
NZ (1) | NZ578235A (fr) |
TN (1) | TN2009000323A1 (fr) |
WO (1) | WO2008092894A1 (fr) |
ZA (1) | ZA200904676B (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ512122A (en) | 1998-11-27 | 2003-12-19 | Darwin Discovery Ltd | Compositions and methods for increasing bone mineralization |
CA2529623A1 (fr) | 2003-06-16 | 2005-02-17 | Celltech R & D, Inc. | Anticorps specifiques de la sclerostine et methodes permettant d'accroitre la mineralisation osseuse |
US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
WO2007080129A1 (fr) * | 2006-01-13 | 2007-07-19 | A Chan Holding B.V. | Traitement et diagnostic de densité osseuse anormale |
AU2008287426B2 (en) * | 2007-08-10 | 2014-06-26 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
EP3211011A1 (fr) | 2007-11-16 | 2017-08-30 | Nuvelo, Inc. | Anticorps pour lrp6 |
AU2010207880B2 (en) * | 2009-01-29 | 2012-03-29 | Commonwealth Scientific Industrial Research Organisation | Measuring G protein coupled receptor activation |
SG185465A1 (en) | 2010-05-14 | 2012-12-28 | Amgen Inc | High concentration antibody formulations |
US8614190B2 (en) | 2010-06-30 | 2013-12-24 | Industrial Technology Research Institute | Thermal responsive composition for treating bone diseases |
EP2412724A1 (fr) * | 2010-07-29 | 2012-02-01 | Centre National de la Recherche Scientifique (C.N.R.S) | Régulation de l'activité 4 glypican pour moduler le sort de cellules souches et leurs utilisations |
KR20180019247A (ko) | 2010-11-05 | 2018-02-23 | 노파르티스 아게 | Il-17 길항제를 사용한 류마티스성 관절염의 치료 방법 |
EA201391248A1 (ru) | 2011-03-01 | 2014-05-30 | Эмджен Инк. | Биспецифические связывающие агенты |
CR20160147A (es) | 2011-03-25 | 2016-08-03 | Amgen Inc | Formulaciones de anticuerpos |
DK2699261T3 (en) | 2011-04-19 | 2018-09-17 | Amgen Inc | Method of treating osteoporosis |
US20140056912A1 (en) | 2011-04-29 | 2014-02-27 | Novartis Ag | Methods of treating squamous cell carcinoma |
EP2739311B9 (fr) | 2011-08-04 | 2018-09-19 | Amgen Inc. | Procédé de traitement de défauts d'espace osseux |
KR20200056473A (ko) | 2011-12-28 | 2020-05-22 | 암젠 인크 | 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법 |
WO2014006100A1 (fr) | 2012-07-05 | 2014-01-09 | Ucb Pharma S.A. | Traitement de maladies osseuses |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
WO2014118705A1 (fr) | 2013-01-31 | 2014-08-07 | Novartis Ag | Procédé de traitement des troubles minéraux et osseux de la maladie rénale chronique en utilisant des antagonistes de la sclérostine |
US9708375B2 (en) * | 2013-03-15 | 2017-07-18 | Amgen Inc. | Inhibitory polypeptides specific to WNT inhibitors |
WO2014155278A2 (fr) | 2013-03-26 | 2014-10-02 | Novartis Ag | Méthodes de traitement de maladies auto-immunes à l'aide d'antagonistes de l'il -17 |
WO2015034330A1 (fr) * | 2013-09-09 | 2015-03-12 | 가톨릭대학교 산학협력단 | Composition pour le traitement ou la prévention de maladies osseuses, comprenant de l'halofuginone comme principe actif |
US10077316B2 (en) | 2013-12-27 | 2018-09-18 | National University Corporation, Kochi University | Esophageal cancer marker and use thereof |
GB2526898A (en) * | 2014-01-13 | 2015-12-09 | Imp Innovations Ltd | Biological materials and therapeutic uses thereof |
EP3094976B1 (fr) * | 2014-01-17 | 2020-03-25 | Minomic International Ltd. | Antigène de surface cellulaire du cancer de la prostate destiné au diagnostic |
MA41142A (fr) | 2014-12-12 | 2017-10-17 | Amgen Inc | Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement |
AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
CA3012985A1 (fr) | 2015-01-27 | 2016-08-04 | Kardiatonos, Inc. | Biomarqueurs de maladies vasculaires |
WO2016208754A1 (fr) * | 2015-06-24 | 2016-12-29 | 学校法人慶應義塾 | Récepteur antigénique immunisant anti-glypicane-1 |
GB201604124D0 (en) | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
JP2019527710A (ja) | 2016-08-08 | 2019-10-03 | アムジエン・インコーポレーテツド | 抗スクレロスチン抗体を用いた結合組織付着の改善方法 |
CN108264568B (zh) * | 2016-12-30 | 2021-11-16 | 博晟生医股份有限公司 | 重组多肽、核酸分子及其组合物以及制造、使用其的方法 |
CA3093457A1 (fr) | 2018-03-30 | 2019-10-03 | Amgen Inc. | Variants d'anticorps anti-c-terminal |
CN110499283A (zh) * | 2018-05-17 | 2019-11-26 | 西安组织工程与再生医学研究所 | Wnt信号通路激活剂在制备改善低碱性磷酸酯酶症干细胞成骨分化能力异常产品中的应用 |
US11819536B2 (en) | 2018-06-22 | 2023-11-21 | The Trustees Of Columbia University In The City Of New York | Sustained release compositions and methods for treatment of temporomandibular joint degeneration |
US20210308265A1 (en) | 2018-08-10 | 2021-10-07 | Amgen Inc. | Method of preparing an antibody pharmaceutical formulation |
CN109734795B (zh) * | 2019-01-17 | 2022-07-12 | 武汉明德生物科技股份有限公司 | 人Lrp4抗原、人Lrp4抗体检测试剂盒及其制备方法与应用 |
EP3921335A4 (fr) * | 2019-02-08 | 2023-02-08 | The Regents Of The University Of California | Compositions et méthodes impliquant la layiline |
MX2022001805A (es) | 2019-08-12 | 2022-06-08 | Amgen Inc | Formulaciones de anticuerpos anti-esclerostina. |
CN112656806B (zh) * | 2020-12-24 | 2022-08-26 | 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) | 多配体蛋白聚糖4的siRNA序列在抑制犬瘟热病毒复制中的应用 |
CN113913463B (zh) * | 2021-09-19 | 2023-08-18 | 郭保生 | 抑制sost基因表达的重组质粒及其骨靶向重组腺相关病毒与应用 |
WO2023114930A1 (fr) * | 2021-12-15 | 2023-06-22 | The George Washington University | Compositions et procédés d'amélioration de l'évolution dirigée de biomolécules |
CN114984225B (zh) * | 2022-06-22 | 2024-02-02 | 中山大学附属第八医院(深圳福田) | hsa_circ_0005773在防治间充质干细胞衰老及骨关节炎中的应用 |
CN117169521A (zh) * | 2023-08-25 | 2023-12-05 | 暨南大学附属第一医院(广州华侨医院) | 一种种植体周围炎质谱负离子模式代谢组学生物标志物及其应用 |
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CA2008304C (fr) * | 1989-01-31 | 2001-03-27 | Craig S. Hill | Dosage de la phosphatase alcaline des os |
JP2003526370A (ja) * | 2000-03-16 | 2003-09-09 | アムジェン インコーポレーテッド | Il−17レセプター様分子およびその使用 |
CA2406192A1 (fr) * | 2000-04-13 | 2001-10-25 | Thomas N. Wight | Composes therapeutiques et procedes associes |
WO2002092020A2 (fr) * | 2001-03-23 | 2002-11-21 | The Burnham Institute | Compositions et procedes pour moduler le depot mineral osseux |
EP1575481A4 (fr) * | 2002-03-01 | 2010-01-06 | Celltech R & D Inc | Procedes destines a accroitre ou a reduire la densite osseuse |
US7169559B2 (en) * | 2002-05-13 | 2007-01-30 | Fonterra Corporate Research and Development Ltd. | LDL receptor-related proteins 1 and 2 and treatment of bone or cartilage conditions |
PT1608399E (pt) * | 2003-03-14 | 2012-04-13 | Ucb Mfg Inc | Complexo de esclerostina e noguina ou cordina, e agentes que modulam a formação do referido complexo |
EP1673470A2 (fr) * | 2003-09-18 | 2006-06-28 | Genmab A/S | Polypeptides specifiques de tumeur d'expression differentielle utilisables pour le diagnostic et le traitement du cancer |
US8461155B2 (en) * | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
US20080254033A1 (en) * | 2004-01-21 | 2008-10-16 | Kristen Pierce | Pharmaceutical Compositions Containing Antagonists to Lrp4, Lrp8 or Megalin for Treatment of Diseases |
CN101061217A (zh) * | 2004-02-27 | 2007-10-24 | 通用医疗公司 | 用于毛发生长的方法和组合物 |
AU2005264579B2 (en) * | 2004-07-22 | 2010-06-10 | Eisai R&D Management Co., Ltd. | Lrp4/Corin dopaminergic neuron progenitor cell markers |
WO2007021003A1 (fr) * | 2005-08-18 | 2007-02-22 | Eisai R & D Management Co., Ltd. | Nato3, MARQUEUR DE CELLULE PROGÉNITRICE DE CROISSANCE DE NEURONE PRODUCTEUR DE DOPAMINE |
WO2007080129A1 (fr) * | 2006-01-13 | 2007-07-19 | A Chan Holding B.V. | Traitement et diagnostic de densité osseuse anormale |
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2008
- 2008-01-30 US US12/525,631 patent/US20100028335A1/en not_active Abandoned
- 2008-01-30 CA CA002675639A patent/CA2675639A1/fr not_active Abandoned
- 2008-01-30 WO PCT/EP2008/051128 patent/WO2008092894A1/fr active Application Filing
- 2008-01-30 EP EP08708443A patent/EP2114435A1/fr not_active Withdrawn
- 2008-01-30 JP JP2009547684A patent/JP2010526766A/ja active Pending
- 2008-01-30 EA EA200901031A patent/EA200901031A1/ru unknown
- 2008-01-30 BR BRPI0807205-1A patent/BRPI0807205A2/pt not_active IP Right Cessation
- 2008-01-30 KR KR1020097016132A patent/KR20090115133A/ko not_active Application Discontinuation
- 2008-01-30 NZ NZ578235A patent/NZ578235A/en not_active IP Right Cessation
- 2008-01-30 CN CN200880003181A patent/CN101616684A/zh active Pending
- 2008-01-30 AU AU2008209713A patent/AU2008209713B2/en not_active Ceased
- 2008-01-30 MX MX2009008096A patent/MX2009008096A/es not_active Application Discontinuation
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2009
- 2009-07-03 ZA ZA200904676A patent/ZA200904676B/xx unknown
- 2009-07-13 IL IL199834A patent/IL199834A0/en unknown
- 2009-07-24 MA MA32118A patent/MA31156B1/fr unknown
- 2009-07-31 TN TNP2009000323A patent/TN2009000323A1/fr unknown
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2011
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2013
- 2013-02-27 US US13/779,102 patent/US20130164284A1/en not_active Abandoned
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IL199834A0 (en) | 2010-04-15 |
CN101616684A (zh) | 2009-12-30 |
EA200901031A1 (ru) | 2010-04-30 |
US20120003219A1 (en) | 2012-01-05 |
MA31156B1 (fr) | 2010-02-01 |
KR20090115133A (ko) | 2009-11-04 |
MX2009008096A (es) | 2009-08-07 |
TN2009000323A1 (en) | 2010-12-31 |
BRPI0807205A2 (pt) | 2014-07-22 |
CA2675639A1 (fr) | 2008-08-07 |
WO2008092894A1 (fr) | 2008-08-07 |
AU2008209713B2 (en) | 2012-01-19 |
AU2008209713A1 (en) | 2008-08-07 |
NZ578235A (en) | 2012-05-25 |
US20100028335A1 (en) | 2010-02-04 |
EP2114435A1 (fr) | 2009-11-11 |
JP2010526766A (ja) | 2010-08-05 |
US20130164284A1 (en) | 2013-06-27 |
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