ZA200903550B - Substituted isoquinoline and isoquinolinone derivatives as inhibitors of Rho-kinase - Google Patents

Substituted isoquinoline and isoquinolinone derivatives as inhibitors of Rho-kinase

Info

Publication number
ZA200903550B
ZA200903550B ZA200903550A ZA200903550A ZA200903550B ZA 200903550 B ZA200903550 B ZA 200903550B ZA 200903550 A ZA200903550 A ZA 200903550A ZA 200903550 A ZA200903550 A ZA 200903550A ZA 200903550 B ZA200903550 B ZA 200903550B
Authority
ZA
South Africa
Prior art keywords
rho
kinase
inhibitors
substituted isoquinoline
isoquinolinone derivatives
Prior art date
Application number
ZA200903550A
Other languages
English (en)
Inventor
Oliver Plettenburg
Armin Hofmeister
Joachim Brendel
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38191090&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200903550(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ZA200903550B publication Critical patent/ZA200903550B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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ZA200903550A 2006-12-27 2009-05-22 Substituted isoquinoline and isoquinolinone derivatives as inhibitors of Rho-kinase ZA200903550B (en)

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Application Number Priority Date Filing Date Title
EP06026898 2006-12-27

Publications (1)

Publication Number Publication Date
ZA200903550B true ZA200903550B (en) 2010-04-28

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ZA200903550A ZA200903550B (en) 2006-12-27 2009-05-22 Substituted isoquinoline and isoquinolinone derivatives as inhibitors of Rho-kinase

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US (2) US8278294B2 (cg-RX-API-DMAC7.html)
EP (1) EP2102187B1 (cg-RX-API-DMAC7.html)
JP (1) JP5421783B2 (cg-RX-API-DMAC7.html)
KR (1) KR101517154B1 (cg-RX-API-DMAC7.html)
CN (1) CN101616909B (cg-RX-API-DMAC7.html)
AR (1) AR064533A1 (cg-RX-API-DMAC7.html)
AU (1) AU2007338406B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0720862A2 (cg-RX-API-DMAC7.html)
CA (1) CA2673916C (cg-RX-API-DMAC7.html)
CL (1) CL2007003822A1 (cg-RX-API-DMAC7.html)
CO (1) CO6321138A2 (cg-RX-API-DMAC7.html)
CR (1) CR10812A (cg-RX-API-DMAC7.html)
DO (1) DOP2009000163A (cg-RX-API-DMAC7.html)
EC (1) ECSP099466A (cg-RX-API-DMAC7.html)
IL (1) IL199541A (cg-RX-API-DMAC7.html)
MA (1) MA31021B1 (cg-RX-API-DMAC7.html)
MX (1) MX2009005825A (cg-RX-API-DMAC7.html)
MY (1) MY150746A (cg-RX-API-DMAC7.html)
NI (1) NI200900107A (cg-RX-API-DMAC7.html)
NO (1) NO20092421L (cg-RX-API-DMAC7.html)
NZ (1) NZ577981A (cg-RX-API-DMAC7.html)
RU (1) RU2455302C2 (cg-RX-API-DMAC7.html)
TN (1) TN2009000270A1 (cg-RX-API-DMAC7.html)
TW (1) TWI435723B (cg-RX-API-DMAC7.html)
UY (1) UY30840A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008077550A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200903550B (cg-RX-API-DMAC7.html)

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