ZA200901510B - Solid citrate and tartrate salts of DPP-IV inhibitors - Google Patents
Solid citrate and tartrate salts of DPP-IV inhibitorsInfo
- Publication number
- ZA200901510B ZA200901510B ZA200901510A ZA200901510A ZA200901510B ZA 200901510 B ZA200901510 B ZA 200901510B ZA 200901510 A ZA200901510 A ZA 200901510A ZA 200901510 A ZA200901510 A ZA 200901510A ZA 200901510 B ZA200901510 B ZA 200901510B
- Authority
- ZA
- South Africa
- Prior art keywords
- dpp
- inhibitors
- tartrate salts
- solid citrate
- citrate
- Prior art date
Links
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 title 1
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 title 1
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- 150000003892 tartrate salts Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84109706P | 2006-08-30 | 2006-08-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200901510B true ZA200901510B (en) | 2010-05-26 |
Family
ID=39136484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200901510A ZA200901510B (en) | 2006-08-30 | 2009-03-03 | Solid citrate and tartrate salts of DPP-IV inhibitors |
Country Status (18)
Country | Link |
---|---|
US (1) | US8299271B2 (zh) |
EP (1) | EP2061474A4 (zh) |
JP (1) | JP5264728B2 (zh) |
KR (1) | KR101504769B1 (zh) |
CN (1) | CN101522201B (zh) |
AR (2) | AR062590A1 (zh) |
AU (1) | AU2007290684B2 (zh) |
BR (1) | BRPI0715447B8 (zh) |
CA (1) | CA2661776C (zh) |
CL (1) | CL2007002499A1 (zh) |
EA (1) | EA017833B1 (zh) |
HK (1) | HK1134248A1 (zh) |
IL (2) | IL197225A (zh) |
MX (1) | MX2009002281A (zh) |
NO (1) | NO20091291L (zh) |
TW (1) | TW200817324A (zh) |
WO (1) | WO2008027273A2 (zh) |
ZA (1) | ZA200901510B (zh) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2007002499A1 (es) | 2006-08-30 | 2008-03-14 | Phenomix Corp | Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes. |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
GEP201706703B (en) | 2008-06-17 | 2017-07-25 | Millennium Pharmaceuticals Inc (A Delaware Corporation) | Boronate ester compounds and pharmaceutical compositions thereof |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
CA2735562C (en) | 2008-08-15 | 2017-10-17 | Boehringer Ingelheim International Gmbh | Dpp-4 inhibitors for wound healing |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
AR075204A1 (es) | 2009-01-29 | 2011-03-16 | Boehringer Ingelheim Int | Inhibidores de dpp-4 y composiciones farmaceuticas que los comprenden, utiles para tratar enfermedades metabolicas en pacientes pediatricos, particularmente diabetes mellitus tipo 2 |
NZ594044A (en) | 2009-02-13 | 2014-08-29 | Boehringer Ingelheim Int | Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics |
AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
JP2013512229A (ja) | 2009-11-27 | 2013-04-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 遺伝子型が同定された糖尿病患者のリナグリプチン等のddp−iv阻害薬による治療 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
CN102286011B (zh) * | 2010-03-16 | 2017-10-03 | 美德(江西)生物科技有限公司 | 吡咯烷硼酸酯二肽基肽酶抑制剂及其药物组合物 |
WO2011113947A1 (en) | 2010-03-18 | 2011-09-22 | Boehringer Ingelheim International Gmbh | Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions |
MX2012011631A (es) | 2010-04-06 | 2013-01-18 | Arena Pharm Inc | Moduladores del receptor gpr119 y el tratamiento de trastornos relacionados con el mismo. |
BR112012028136A2 (pt) | 2010-05-05 | 2016-08-09 | Boehringer Ingelheim Int | terapia de combinaçao |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
EP3725325B1 (en) | 2010-06-24 | 2023-05-31 | Boehringer Ingelheim International GmbH | Diabetes therapy |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
CN103003253A (zh) * | 2010-08-05 | 2013-03-27 | 贝林格尔.英格海姆国际有限公司 | 2-{2-[[(4-甲氧基-2,6-二甲基苯基)磺酰基]-(甲基)氨基]乙氧基}-n-甲基-n-[3-(4-甲基哌嗪-1-基)环己基]乙酰胺的酸加成盐及其作为缓激肽b1受体拮抗剂的用途 |
CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012135570A1 (en) | 2011-04-01 | 2012-10-04 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
US20140066369A1 (en) | 2011-04-19 | 2014-03-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
US20140038889A1 (en) | 2011-04-22 | 2014-02-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
CN103483363B (zh) * | 2012-06-13 | 2016-12-21 | 上海赛迦化工产品有限公司 | 多样性的手性氨基硼酸及其制备方法和应用 |
CN105142621A (zh) | 2012-10-24 | 2015-12-09 | 国家健康科学研究所 | 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂 |
WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
JP2014129255A (ja) * | 2012-12-28 | 2014-07-10 | Fujifilm Corp | 組成物およびフィルムならびにそれらの製造方法 |
MA39964A (fr) | 2014-05-20 | 2015-11-26 | Millennium Pharm Inc | Inhibiteurs du protéasome contenant du bore destinés à être utilisés après une thérapie contre le cancer primaire |
ES2805743T3 (es) | 2015-03-24 | 2021-02-15 | Inst Nat Sante Rech Med | Método y composición farmacéutica para uso en el tratamiento de la diabetes |
KR101978364B1 (ko) | 2017-06-15 | 2019-05-14 | 크리스탈지노믹스(주) | 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드 또는 그 유도체의 약학적으로 허용 가능한 염 및 그 제조방법 |
CN111533675B (zh) * | 2019-11-29 | 2021-09-28 | 杭州华东医药集团新药研究院有限公司 | 杂环硼酸化合物的杂质及其控制方法 |
CN111537622B (zh) * | 2019-11-29 | 2021-11-26 | 杭州华东医药集团新药研究院有限公司 | 一种度格列汀及其盐的杂质的检测方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2524916T3 (es) * | 2003-11-12 | 2014-12-15 | Sino-Med International Alliance, Inc. | Compuestos heterocíclicos de ácido borónico |
US7317109B2 (en) * | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
AU2006275697A1 (en) * | 2005-08-01 | 2007-02-08 | Phenomix Corporation | Methods of preparing hetercyclic boronic acids and derivatives thereof |
CL2007002499A1 (es) | 2006-08-30 | 2008-03-14 | Phenomix Corp | Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes. |
CA2661863A1 (en) | 2006-08-30 | 2008-03-06 | F. Hoffmann-La Roche Ag | Inhibitors for glyt-1 |
KR20090060314A (ko) | 2006-08-30 | 2009-06-11 | 셀진 코포레이션 | 5-치환 이소인돌린 화합물 |
PE20080668A1 (es) | 2006-08-30 | 2008-07-17 | Novartis Ag | Compuestos heterociclicos como inhibidores de la cinasa-2 de proteina activada por cinasa de proteina activada por mitogeno |
MX2009009575A (es) | 2007-03-08 | 2009-11-12 | Phenomix Corp | Metodos e intemediarios para la sintesis de inhibidores selectivos de dpp-iv. |
-
2007
- 2007-06-27 CL CL200702499A patent/CL2007002499A1/es unknown
- 2007-08-23 AU AU2007290684A patent/AU2007290684B2/en active Active
- 2007-08-23 CN CN200780036564.9A patent/CN101522201B/zh active Active
- 2007-08-23 KR KR1020097006270A patent/KR101504769B1/ko active IP Right Grant
- 2007-08-23 MX MX2009002281A patent/MX2009002281A/es active IP Right Grant
- 2007-08-23 EA EA200900375A patent/EA017833B1/ru unknown
- 2007-08-23 JP JP2009526645A patent/JP5264728B2/ja active Active
- 2007-08-23 EP EP07837254A patent/EP2061474A4/en not_active Withdrawn
- 2007-08-23 WO PCT/US2007/018629 patent/WO2008027273A2/en active Application Filing
- 2007-08-23 CA CA2661776A patent/CA2661776C/en active Active
- 2007-08-23 US US12/439,140 patent/US8299271B2/en active Active
- 2007-08-23 BR BRPI0715447A patent/BRPI0715447B8/pt active IP Right Grant
- 2007-08-29 AR ARP070103842A patent/AR062590A1/es unknown
- 2007-08-30 TW TW096132256A patent/TW200817324A/zh unknown
-
2009
- 2009-02-24 IL IL197225A patent/IL197225A/en active IP Right Grant
- 2009-03-03 ZA ZA200901510A patent/ZA200901510B/xx unknown
- 2009-03-27 NO NO20091291A patent/NO20091291L/no not_active Application Discontinuation
-
2010
- 2010-02-10 HK HK10101516.1A patent/HK1134248A1/zh unknown
-
2015
- 2015-10-26 IL IL242267A patent/IL242267A/en active IP Right Grant
-
2017
- 2017-07-21 AR ARP170102064A patent/AR109135A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2007002499A1 (es) | 2008-03-14 |
CA2661776A1 (en) | 2008-03-06 |
AU2007290684A1 (en) | 2008-03-06 |
AR062590A1 (es) | 2008-11-19 |
KR101504769B1 (ko) | 2015-03-20 |
AU2007290684B2 (en) | 2012-08-16 |
BRPI0715447A2 (pt) | 2014-05-06 |
JP2010502610A (ja) | 2010-01-28 |
EA200900375A1 (ru) | 2009-10-30 |
CN101522201B (zh) | 2015-08-19 |
EA017833B1 (ru) | 2013-03-29 |
US20100323988A1 (en) | 2010-12-23 |
IL197225A (en) | 2015-11-30 |
CA2661776C (en) | 2015-03-24 |
KR20090043601A (ko) | 2009-05-06 |
IL242267A (en) | 2017-12-31 |
TW200817324A (en) | 2008-04-16 |
EP2061474A4 (en) | 2011-06-15 |
HK1134248A1 (zh) | 2010-04-23 |
WO2008027273A2 (en) | 2008-03-06 |
IL197225A0 (en) | 2009-12-24 |
US8299271B2 (en) | 2012-10-30 |
WO2008027273A3 (en) | 2008-07-31 |
NO20091291L (no) | 2009-03-27 |
MX2009002281A (es) | 2009-05-20 |
IL242267A0 (en) | 2015-11-30 |
BRPI0715447B8 (pt) | 2021-05-25 |
CN101522201A (zh) | 2009-09-02 |
BRPI0715447B1 (pt) | 2020-09-15 |
JP5264728B2 (ja) | 2013-08-14 |
AR109135A2 (es) | 2018-10-31 |
EP2061474A2 (en) | 2009-05-27 |
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