ZA200809690B - Substituted in 5-phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxycyclohexane carboxylic acid as inhibitors of acetyl coenzyme a diacylglycerol acyltransferase - Google Patents
Substituted in 5-phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxycyclohexane carboxylic acid as inhibitors of acetyl coenzyme a diacylglycerol acyltransferaseInfo
- Publication number
- ZA200809690B ZA200809690B ZA200809690A ZA200809690A ZA200809690B ZA 200809690 B ZA200809690 B ZA 200809690B ZA 200809690 A ZA200809690 A ZA 200809690A ZA 200809690 A ZA200809690 A ZA 200809690A ZA 200809690 B ZA200809690 B ZA 200809690B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenoxycyclohexane
- ylcarbonylamino
- oxadiazol
- phenylamino
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80929806P | 2006-05-30 | 2006-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200809690B true ZA200809690B (en) | 2010-04-28 |
Family
ID=38255814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200809690A ZA200809690B (en) | 2006-05-30 | 2008-11-13 | Substituted in 5-phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxycyclohexane carboxylic acid as inhibitors of acetyl coenzyme a diacylglycerol acyltransferase |
Country Status (18)
Country | Link |
---|---|
US (1) | US8084478B2 (xx) |
EP (1) | EP2041100B1 (xx) |
JP (1) | JP2009538892A (xx) |
KR (1) | KR20090012349A (xx) |
CN (1) | CN101472905B (xx) |
AT (1) | ATE492541T1 (xx) |
AU (1) | AU2007266796B2 (xx) |
BR (1) | BRPI0712802A2 (xx) |
CA (1) | CA2651710A1 (xx) |
DE (1) | DE602007011446D1 (xx) |
ES (1) | ES2356097T3 (xx) |
HK (1) | HK1128687A1 (xx) |
IL (1) | IL195126A0 (xx) |
MX (1) | MX2008015228A (xx) |
NO (1) | NO20084732L (xx) |
NZ (1) | NZ572586A (xx) |
WO (1) | WO2007138311A1 (xx) |
ZA (1) | ZA200809690B (xx) |
Families Citing this family (20)
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KR20070087096A (ko) * | 2004-12-14 | 2007-08-27 | 아스트라제네카 아베 | Dgat 억제제로서의 옥사디아졸 유도체 |
EP1966221A1 (en) | 2005-12-22 | 2008-09-10 | AstraZeneca AB | Pyrimido- [4, 5-]-oxazines for use as dgat inhibitors |
ATE529405T1 (de) | 2006-03-31 | 2011-11-15 | Novartis Ag | (4-(4-ä6-(trifluoromethyl-pyridin-3-ylamino)-n- enthaltend-heteroarylü-phenyl)-cyclohexyl)- essigsäure-derivate und ihre pharmazeutische anwendungen |
WO2007138304A1 (en) * | 2006-05-30 | 2007-12-06 | Astrazeneca Ab | 1, 3, 4 -oxadiazole derivatives as dgat1 inhibitors |
ATE500251T1 (de) * | 2006-06-08 | 2011-03-15 | Astrazeneca Ab | Benzimidazole und ihre verwendung zur behandlung von diabetes |
CA2695434A1 (en) * | 2007-08-17 | 2009-02-26 | Astrazeneca Ab | Chemical compounds 979 |
AR066169A1 (es) | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
CA2707660A1 (en) | 2007-12-20 | 2009-07-02 | Astrazeneca Ab | Carbamoyl compounds as dgat1 inhibitors 190 |
WO2010023609A1 (en) * | 2008-08-25 | 2010-03-04 | Piramal Life Sciences Limited | Oxazole, oxadiazole and thiazole derivatives as diacylglycerol acyltranferase inhibitors |
EP2379516A1 (en) * | 2008-12-19 | 2011-10-26 | AstraZeneca AB | 1,3,4-oxadiazole derivatives and their uses to treat diabetes |
EP3366686B9 (en) | 2009-03-20 | 2021-08-04 | Metabasis Therapeutics, Inc. | Inhibitors of diacylglycerol o-acyltransferase 1 (dgat-1) and uses thereof |
MX2011011178A (es) | 2009-04-21 | 2011-12-06 | Astellas Pharma Inc | Compuesto de diaciletilendiamina. |
JP2012530122A (ja) * | 2009-06-19 | 2012-11-29 | アストラゼネカ アクチボラグ | Dgat1の阻害剤としてのピラジンカルボキシアミド |
FR2963005B1 (fr) * | 2010-07-23 | 2012-08-17 | Sanofi Aventis | Derives d'oxadiazoles et de pyridazines, leur preparation et leur application en therapeutique |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
JP6099753B2 (ja) * | 2012-10-03 | 2017-03-22 | アドビナス セラピューティクス リミテッド | スピロ環化合物、その組成物及びその医薬応用 |
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-
2007
- 2007-05-29 CA CA002651710A patent/CA2651710A1/en not_active Abandoned
- 2007-05-29 BR BRPI0712802-9A patent/BRPI0712802A2/pt not_active IP Right Cessation
- 2007-05-29 NZ NZ572586A patent/NZ572586A/en not_active IP Right Cessation
- 2007-05-29 ES ES07733006T patent/ES2356097T3/es active Active
- 2007-05-29 AU AU2007266796A patent/AU2007266796B2/en not_active Ceased
- 2007-05-29 DE DE602007011446T patent/DE602007011446D1/de active Active
- 2007-05-29 CN CN2007800203199A patent/CN101472905B/zh not_active Expired - Fee Related
- 2007-05-29 AT AT07733006T patent/ATE492541T1/de not_active IP Right Cessation
- 2007-05-29 EP EP07733006A patent/EP2041100B1/en active Active
- 2007-05-29 MX MX2008015228A patent/MX2008015228A/es active IP Right Grant
- 2007-05-29 JP JP2009512664A patent/JP2009538892A/ja active Pending
- 2007-05-29 US US12/302,185 patent/US8084478B2/en not_active Expired - Fee Related
- 2007-05-29 KR KR1020087029467A patent/KR20090012349A/ko not_active Application Discontinuation
- 2007-05-29 WO PCT/GB2007/001990 patent/WO2007138311A1/en active Application Filing
-
2008
- 2008-11-05 IL IL195126A patent/IL195126A0/en unknown
- 2008-11-10 NO NO20084732A patent/NO20084732L/no not_active Application Discontinuation
- 2008-11-13 ZA ZA200809690A patent/ZA200809690B/xx unknown
-
2009
- 2009-07-22 HK HK09106693.8A patent/HK1128687A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20090275620A1 (en) | 2009-11-05 |
BRPI0712802A2 (pt) | 2012-10-23 |
MX2008015228A (es) | 2008-12-12 |
EP2041100B1 (en) | 2010-12-22 |
AU2007266796A1 (en) | 2007-12-06 |
CN101472905B (zh) | 2011-12-14 |
CN101472905A (zh) | 2009-07-01 |
JP2009538892A (ja) | 2009-11-12 |
US8084478B2 (en) | 2011-12-27 |
ATE492541T1 (de) | 2011-01-15 |
NZ572586A (en) | 2011-03-31 |
ES2356097T3 (es) | 2011-04-04 |
IL195126A0 (en) | 2011-08-01 |
DE602007011446D1 (en) | 2011-02-03 |
NO20084732L (no) | 2008-12-12 |
KR20090012349A (ko) | 2009-02-03 |
EP2041100A1 (en) | 2009-04-01 |
WO2007138311A1 (en) | 2007-12-06 |
CA2651710A1 (en) | 2007-12-06 |
AU2007266796B2 (en) | 2011-02-10 |
HK1128687A1 (en) | 2009-11-06 |
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