NO20084732L - Substituerte 5-fenylamino- 1, 3, 4-oksadiazol-2-ylcarbonylamino-4-fenoksy-cycloheksane karboksylsyre som inhibitorer av acetyl koenzym A diacylglyserol acyltransferase - Google Patents

Substituerte 5-fenylamino- 1, 3, 4-oksadiazol-2-ylcarbonylamino-4-fenoksy-cycloheksane karboksylsyre som inhibitorer av acetyl koenzym A diacylglyserol acyltransferase

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Publication number
NO20084732L
NO20084732L NO20084732A NO20084732A NO20084732L NO 20084732 L NO20084732 L NO 20084732L NO 20084732 A NO20084732 A NO 20084732A NO 20084732 A NO20084732 A NO 20084732A NO 20084732 L NO20084732 L NO 20084732L
Authority
NO
Norway
Prior art keywords
ylcarbonylamino
oxadiazol
phenylamino
phenoxy
inhibitors
Prior art date
Application number
NO20084732A
Other languages
English (en)
Inventor
Roger John Butlin
Alleyn Plowright
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20084732L publication Critical patent/NO20084732L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

Abstract

Det tilveiebringes forbindelser med formel (I): eller salter derav, som hemmer acetyl-CoA (acetyl-koenzym A):diacylglycerol-acyltransferase- (DGAT1) aktivitet, hvor R1, R2 og R3 hver, uavhengig, er valgt fra hydrogen, fluor, klor, cyano, trifluormetyl, trifluormetoksy og difluormetoksy, sammen med fremgangsmåter for fremstilling av dem, farmasøytiske preparater inneholdende dem, og anvendelse av dem som medikamenter.
NO20084732A 2006-05-30 2008-11-10 Substituerte 5-fenylamino- 1, 3, 4-oksadiazol-2-ylcarbonylamino-4-fenoksy-cycloheksane karboksylsyre som inhibitorer av acetyl koenzym A diacylglyserol acyltransferase NO20084732L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80929806P 2006-05-30 2006-05-30
PCT/GB2007/001990 WO2007138311A1 (en) 2006-05-30 2007-05-29 Substituted 5- phenylamino- 1, 3, 4-oxadiaz0l-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme a diacylglycerol acyltransferase

Publications (1)

Publication Number Publication Date
NO20084732L true NO20084732L (no) 2008-12-12

Family

ID=38255814

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084732A NO20084732L (no) 2006-05-30 2008-11-10 Substituerte 5-fenylamino- 1, 3, 4-oksadiazol-2-ylcarbonylamino-4-fenoksy-cycloheksane karboksylsyre som inhibitorer av acetyl koenzym A diacylglyserol acyltransferase

Country Status (18)

Country Link
US (1) US8084478B2 (no)
EP (1) EP2041100B1 (no)
JP (1) JP2009538892A (no)
KR (1) KR20090012349A (no)
CN (1) CN101472905B (no)
AT (1) ATE492541T1 (no)
AU (1) AU2007266796B2 (no)
BR (1) BRPI0712802A2 (no)
CA (1) CA2651710A1 (no)
DE (1) DE602007011446D1 (no)
ES (1) ES2356097T3 (no)
HK (1) HK1128687A1 (no)
IL (1) IL195126A0 (no)
MX (1) MX2008015228A (no)
NO (1) NO20084732L (no)
NZ (1) NZ572586A (no)
WO (1) WO2007138311A1 (no)
ZA (1) ZA200809690B (no)

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MX2008015228A (es) 2008-12-12
EP2041100B1 (en) 2010-12-22
AU2007266796A1 (en) 2007-12-06
CN101472905B (zh) 2011-12-14
CN101472905A (zh) 2009-07-01
JP2009538892A (ja) 2009-11-12
US8084478B2 (en) 2011-12-27
ATE492541T1 (de) 2011-01-15
ZA200809690B (en) 2010-04-28
NZ572586A (en) 2011-03-31
ES2356097T3 (es) 2011-04-04
IL195126A0 (en) 2011-08-01
DE602007011446D1 (en) 2011-02-03
KR20090012349A (ko) 2009-02-03
EP2041100A1 (en) 2009-04-01
WO2007138311A1 (en) 2007-12-06
CA2651710A1 (en) 2007-12-06
AU2007266796B2 (en) 2011-02-10
HK1128687A1 (en) 2009-11-06

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