ZA200806016B - Novel collection of HCDR3 regions and uses therefor - Google Patents

Novel collection of HCDR3 regions and uses therefor

Info

Publication number
ZA200806016B
ZA200806016B ZA200806016A ZA200806016A ZA200806016B ZA 200806016 B ZA200806016 B ZA 200806016B ZA 200806016 A ZA200806016 A ZA 200806016A ZA 200806016 A ZA200806016 A ZA 200806016A ZA 200806016 B ZA200806016 B ZA 200806016B
Authority
ZA
South Africa
Prior art keywords
uses therefor
novel collection
hcdr3 regions
hcdr3
regions
Prior art date
Application number
ZA200806016A
Other languages
English (en)
Inventor
Enzelberger Markus
Thiel Stefanie
Prassler Josef
Urlinger Stefanie
Rothe Christine
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of ZA200806016B publication Critical patent/ZA200806016B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA200806016A 2005-12-20 2008-07-10 Novel collection of HCDR3 regions and uses therefor ZA200806016B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75163305P 2005-12-20 2005-12-20

Publications (1)

Publication Number Publication Date
ZA200806016B true ZA200806016B (en) 2009-07-29

Family

ID=39273832

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200806016A ZA200806016B (en) 2005-12-20 2008-07-10 Novel collection of HCDR3 regions and uses therefor

Country Status (15)

Country Link
US (1) US8273688B2 (fr)
EP (1) EP1979378B1 (fr)
JP (1) JP5405831B2 (fr)
KR (1) KR20080080653A (fr)
CN (1) CN101389655B (fr)
AU (1) AU2006350452B2 (fr)
CA (1) CA2634387C (fr)
DK (1) DK1979378T3 (fr)
ES (1) ES2394722T3 (fr)
IL (1) IL192315A0 (fr)
MX (1) MX2008008220A (fr)
NO (1) NO20083171L (fr)
NZ (1) NZ569359A (fr)
WO (1) WO2008053275A2 (fr)
ZA (1) ZA200806016B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US20030133939A1 (en) * 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
EP2298815B1 (fr) * 2005-07-25 2015-03-11 Emergent Product Development Seattle, LLC Reduction de lymphocytes B au moyen de molecules de liaison specifique de CD37 et specifique de CD20
KR101571027B1 (ko) * 2006-06-12 2015-11-23 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 효과기 기능을 갖는 단일쇄 다가 결합 단백질
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8691730B2 (en) * 2007-09-14 2014-04-08 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP2098536A1 (fr) 2008-03-05 2009-09-09 4-Antibody AG Isolation et identification de protéines de liaison spécifiques à des antigènes ou à des ligands
US9873957B2 (en) * 2008-03-13 2018-01-23 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
WO2009126944A1 (fr) * 2008-04-11 2009-10-15 Trubion Pharmaceuticals, Inc. Produits d’immunothérapie de cd37 et combinaison avec un produit chimiothérapique bifonctionnel de celui-ci
CA2968164C (fr) 2008-04-24 2019-08-20 Dyax Corp. Bibliotheques de materiels genetiques comprenant de nouvelles conceptions cdr1, cdr2 et cdr3 hc et de nouvelles conceptions cdr1, cdr2 et cdr3 lc
DK2435568T3 (da) 2009-05-29 2014-09-08 Morphosys Ag Samling af syntetiske antistoffer til behandling af sygdom
US20110082054A1 (en) * 2009-09-14 2011-04-07 Dyax Corp. Libraries of genetic packages comprising novel hc cdr3 designs
EP2593594B1 (fr) 2010-07-16 2017-09-27 Adimab, LLC Banques d'anticorps
RU2603080C2 (ru) 2010-11-19 2016-11-20 МорфоСис АГ Коллекция и способы ее применения
SG10202002577XA (en) 2015-09-21 2020-04-29 Aptevo Res & Development Llc Cd3 binding polypeptides
CN105274630A (zh) * 2015-11-25 2016-01-27 苏州泓迅生物科技有限公司 基于组合合成技术合成可控的人源化抗体库的方法与应用
US11230706B2 (en) 2016-01-19 2022-01-25 Zumutor Biologics, Inc. Method of generating a synthetic antibody library, said library and application(s) thereof
EP3293293A1 (fr) * 2016-09-08 2018-03-14 Italfarmaco SpA Bibliothèques uniquement de hc-cdr3-avec redondance combinatoire réduite et distribution de longueur de boucle optimisée

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0859841T3 (da) 1995-08-18 2002-09-09 Morphosys Ag Protein/(poly)peptidbiblioteker
US6828422B1 (en) * 1995-08-18 2004-12-07 Morphosys Ag Protein/(poly)peptide libraries
PT1144607E (pt) 1999-07-20 2009-04-22 Morphosys Ag Novos métodos para apresentar (poli)peptídeos/ proteínas em partículas bacteriofágicas através de ligações dissulfureto
EP1360288B1 (fr) 2000-12-18 2011-02-16 Dyax Corp. Banques ciblees de capsides genetiques

Also Published As

Publication number Publication date
KR20080080653A (ko) 2008-09-04
ES2394722T3 (es) 2013-02-05
NZ569359A (en) 2011-11-25
US8273688B2 (en) 2012-09-25
DK1979378T3 (da) 2012-10-29
CN101389655B (zh) 2013-05-22
EP1979378A2 (fr) 2008-10-15
NO20083171L (no) 2008-08-27
MX2008008220A (es) 2009-03-04
JP5405831B2 (ja) 2014-02-05
WO2008053275A2 (fr) 2008-05-08
AU2006350452B2 (en) 2012-10-25
JP2009519727A (ja) 2009-05-21
IL192315A0 (en) 2008-12-29
CA2634387C (fr) 2015-11-24
CA2634387A1 (fr) 2008-05-08
AU2006350452A1 (en) 2008-05-08
CN101389655A (zh) 2009-03-18
WO2008053275A3 (fr) 2008-08-21
US20090088346A1 (en) 2009-04-02
EP1979378B1 (fr) 2012-07-25

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