ZA200805341B - Bi-platinum complexes with antitumor activity - Google Patents
Bi-platinum complexes with antitumor activityInfo
- Publication number
- ZA200805341B ZA200805341B ZA200805341A ZA200805341A ZA200805341B ZA 200805341 B ZA200805341 B ZA 200805341B ZA 200805341 A ZA200805341 A ZA 200805341A ZA 200805341 A ZA200805341 A ZA 200805341A ZA 200805341 B ZA200805341 B ZA 200805341B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- sulphate
- hydrogen
- antitumor activity
- platinum complexes
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- 229910002651 NO3 Inorganic materials 0.000 abstract 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 abstract 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 abstract 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 abstract 2
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002449A ITMI20052449A1 (it) | 2005-12-22 | 2005-12-22 | Nuovi bis-platino complessi ad attivita' antitumorale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200805341B true ZA200805341B (en) | 2009-10-28 |
Family
ID=37907243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200805341A ZA200805341B (en) | 2005-12-22 | 2006-12-21 | Bi-platinum complexes with antitumor activity |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8426625B2 (ko) |
| EP (1) | EP1968991B9 (ko) |
| JP (1) | JP5436862B2 (ko) |
| KR (1) | KR101415094B1 (ko) |
| CN (1) | CN101341161A (ko) |
| AT (1) | ATE541851T1 (ko) |
| AU (1) | AU2006328970B2 (ko) |
| BR (1) | BRPI0620065A2 (ko) |
| CA (1) | CA2634355C (ko) |
| EA (1) | EA015619B1 (ko) |
| ES (1) | ES2383432T3 (ko) |
| IL (1) | IL192295A0 (ko) |
| IT (1) | ITMI20052449A1 (ko) |
| MX (1) | MX2008007932A (ko) |
| NO (1) | NO20082722L (ko) |
| NZ (1) | NZ569258A (ko) |
| WO (1) | WO2007071415A1 (ko) |
| ZA (1) | ZA200805341B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20052449A1 (it) | 2005-12-22 | 2007-06-23 | Cell Therapeutics Europe Srl | Nuovi bis-platino complessi ad attivita' antitumorale |
| ITMI20081660A1 (it) * | 2008-09-18 | 2010-03-19 | Cell Therapeutics Inc Sede Secon Daria | Complesso di platino ad attivita' antitumorale |
| GB201313423D0 (en) * | 2013-07-26 | 2013-09-11 | Innospec Ltd | Compositions and methods |
| EP3119859A1 (en) * | 2014-03-18 | 2017-01-25 | Council Of Scientific & Industrial Research | Halogen free ionic liquids as lubricant or lubricant additives and a process for the preparation thereof |
| GB201413355D0 (en) * | 2014-07-28 | 2014-09-10 | Innospec Ltd | Compositons and methods |
| CN110075120B (zh) * | 2018-10-11 | 2022-03-11 | 广东众尔健生物科技有限公司 | 一种组合物及其在抗肿瘤药物中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6296A (ja) | 1985-03-06 | 1987-01-06 | Sumitomo Pharmaceut Co Ltd | 脂溶性白金（２）錯体 |
| IT1200467B (it) | 1985-05-06 | 1989-01-18 | Boehringer Biochemia Srl | Formulazione farmaceutica |
| US5117022A (en) | 1985-10-18 | 1992-05-26 | The Board Of Regents, The University Of Texas System | Hydrophobic cis-platinum complexes efficiently incorporated into liposomes |
| JPS63501568A (ja) * | 1985-10-18 | 1988-06-16 | ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム | リポソ−ムに有効に組み込まれた疎水性シス−プラチナ複合体 |
| US4797393A (en) | 1986-07-25 | 1989-01-10 | University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
| US5107007A (en) | 1989-09-01 | 1992-04-21 | The University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
| ES2036553T3 (es) | 1986-10-07 | 1993-06-01 | Boehringer Mannheim Italia S.P.A. | Composiciones farmaceuticas que tienen actividad antineoplastica. |
| ZA976421B (en) | 1996-07-22 | 1998-01-22 | Boehringer Mannheim Italia | New bis-platinum complexes with polyamine ligands as antitumor agents. |
| ZA976422B (en) * | 1996-07-22 | 1998-01-22 | Boehringer Mannheim Italia | New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity. |
| ITMI991508A1 (it) * | 1999-07-09 | 2001-01-09 | Novuspharma Spa | Nitrati di bis-platino complessi con ligandi poliamminici |
| IT1313594B1 (it) * | 1999-08-03 | 2002-09-09 | Novuspharma Spa | Bisplatino complessi attivi per via orale. |
| JP2005501123A (ja) | 2001-08-22 | 2005-01-13 | ヴァージニア コモンウェルス ユニバーシティ | プロドラッグとしての標的ビス白金ポリアミド：白金の選択的放出 |
| EP1734937A1 (en) * | 2004-03-26 | 2006-12-27 | Cell Therapeutics Europe S.R.L. | Nanoparticle formulations of platinum compounds |
| ITMI20052449A1 (it) | 2005-12-22 | 2007-06-23 | Cell Therapeutics Europe Srl | Nuovi bis-platino complessi ad attivita' antitumorale |
-
2005
- 2005-12-22 IT IT002449A patent/ITMI20052449A1/it unknown
-
2006
- 2006-12-21 JP JP2008546261A patent/JP5436862B2/ja not_active Expired - Fee Related
- 2006-12-21 EA EA200801355A patent/EA015619B1/ru not_active IP Right Cessation
- 2006-12-21 CN CNA2006800478888A patent/CN101341161A/zh active Pending
- 2006-12-21 EP EP06829802A patent/EP1968991B9/en not_active Not-in-force
- 2006-12-21 WO PCT/EP2006/012366 patent/WO2007071415A1/en active Application Filing
- 2006-12-21 BR BRPI0620065-6A patent/BRPI0620065A2/pt not_active IP Right Cessation
- 2006-12-21 AT AT06829802T patent/ATE541851T1/de active
- 2006-12-21 ZA ZA200805341A patent/ZA200805341B/xx unknown
- 2006-12-21 US US12/086,547 patent/US8426625B2/en not_active Expired - Fee Related
- 2006-12-21 ES ES06829802T patent/ES2383432T3/es active Active
- 2006-12-21 KR KR1020087014856A patent/KR101415094B1/ko not_active IP Right Cessation
- 2006-12-21 CA CA2634355A patent/CA2634355C/en not_active Expired - Fee Related
- 2006-12-21 MX MX2008007932A patent/MX2008007932A/es active IP Right Grant
- 2006-12-21 NZ NZ569258A patent/NZ569258A/en not_active IP Right Cessation
- 2006-12-21 AU AU2006328970A patent/AU2006328970B2/en not_active Ceased
-
2008
- 2008-06-19 IL IL192295A patent/IL192295A0/en not_active IP Right Cessation
- 2008-06-19 NO NO20082722A patent/NO20082722L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0620065A2 (pt) | 2011-11-01 |
| ATE541851T1 (de) | 2012-02-15 |
| JP5436862B2 (ja) | 2014-03-05 |
| US20100292322A1 (en) | 2010-11-18 |
| CA2634355C (en) | 2015-03-31 |
| ES2383432T3 (es) | 2012-06-21 |
| WO2007071415A1 (en) | 2007-06-28 |
| US8426625B2 (en) | 2013-04-23 |
| AU2006328970A1 (en) | 2007-06-28 |
| EA200801355A1 (ru) | 2008-12-30 |
| EP1968991A1 (en) | 2008-09-17 |
| EP1968991B1 (en) | 2012-01-18 |
| EA015619B1 (ru) | 2011-10-31 |
| MX2008007932A (es) | 2008-09-11 |
| NZ569258A (en) | 2011-08-26 |
| ES2383432T9 (es) | 2012-11-06 |
| AU2006328970B2 (en) | 2012-11-29 |
| NO20082722L (no) | 2008-09-17 |
| KR101415094B1 (ko) | 2014-08-06 |
| CN101341161A (zh) | 2009-01-07 |
| CA2634355A1 (en) | 2007-06-28 |
| IL192295A0 (en) | 2008-12-29 |
| KR20080096643A (ko) | 2008-10-31 |
| JP2009520731A (ja) | 2009-05-28 |
| ITMI20052449A1 (it) | 2007-06-23 |
| EP1968991B9 (en) | 2012-08-08 |
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