EA200801355A1 - Бис-платиновые комплексы с противоопухолевой активностью - Google Patents

Бис-платиновые комплексы с противоопухолевой активностью

Info

Publication number
EA200801355A1
EA200801355A1 EA200801355A EA200801355A EA200801355A1 EA 200801355 A1 EA200801355 A1 EA 200801355A1 EA 200801355 A EA200801355 A EA 200801355A EA 200801355 A EA200801355 A EA 200801355A EA 200801355 A1 EA200801355 A1 EA 200801355A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
bis
sulphate
hydrogen
tumor activity
Prior art date
Application number
EA200801355A
Other languages
English (en)
Other versions
EA015619B1 (ru
Inventor
Альберто Бернареджи
Марио Груньи
Джулио Мариотти
Эрнесто Мента
Джанлука Парди
Паоло Павези
Габриелла Пеццони
Паола Николи
Серджо Де Мунари
Original Assignee
Селл Терапеутикс, Инк.-Седе Секондариа
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селл Терапеутикс, Инк.-Седе Секондариа filed Critical Селл Терапеутикс, Инк.-Седе Секондариа
Publication of EA200801355A1 publication Critical patent/EA200801355A1/ru
Publication of EA015619B1 publication Critical patent/EA015619B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Соединение общей формулы (I)где R выбран из группы, состоящей из (С-С)алкила, (С-С)алкенила, арила, (С-С)аралкила; n и m, каждый независимо, представляет собой целое число от двух до восьми; р равен 1 или 2; А выбран из группы, состоящей из -В-, -B-(CH)-B-, -B-(CH)-B-(CH)-B-, где r и z представляют собой целое число от 2 до 8, В представляет собой -NR- или группу -N(R)l/pQ, где Rвыбран из водорода, (С-С)алкила, (С-С)ацила, трет-бутоксикарбонила и Rвыбран из водорода и (С-С)алкила; Qпредставляет собой анион, выбранный из хлорида, бромида, йодида, нитрата, сульфата, гидросульфата, перхлората, RCOO, где Rимеет такие же значения как R, независимо друг от друга, и R-O-SO, где Rпредставляет собой (С-С)алкил, при условии что, если Qвыбран из хлорида, бромида, йодида, нитрата, сульфата, гидросульфата, перхлората, то R не является (С-С)алкилом.
EA200801355A 2005-12-22 2006-12-21 Бис-платиновые комплексы с противоопухолевой активностью EA015619B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002449A ITMI20052449A1 (it) 2005-12-22 2005-12-22 Nuovi bis-platino complessi ad attivita' antitumorale
PCT/EP2006/012366 WO2007071415A1 (en) 2005-12-22 2006-12-21 Bis-platinum complexes with antitumor activity

Publications (2)

Publication Number Publication Date
EA200801355A1 true EA200801355A1 (ru) 2008-12-30
EA015619B1 EA015619B1 (ru) 2011-10-31

Family

ID=37907243

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801355A EA015619B1 (ru) 2005-12-22 2006-12-21 Бис-платиновые комплексы с противоопухолевой активностью

Country Status (18)

Country Link
US (1) US8426625B2 (ru)
EP (1) EP1968991B9 (ru)
JP (1) JP5436862B2 (ru)
KR (1) KR101415094B1 (ru)
CN (1) CN101341161A (ru)
AT (1) ATE541851T1 (ru)
AU (1) AU2006328970B2 (ru)
BR (1) BRPI0620065A2 (ru)
CA (1) CA2634355C (ru)
EA (1) EA015619B1 (ru)
ES (1) ES2383432T3 (ru)
IL (1) IL192295A0 (ru)
IT (1) ITMI20052449A1 (ru)
MX (1) MX2008007932A (ru)
NO (1) NO20082722L (ru)
NZ (1) NZ569258A (ru)
WO (1) WO2007071415A1 (ru)
ZA (1) ZA200805341B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2702130C2 (ru) * 2013-07-26 2019-10-04 Инноспек Лимитед Четвертичные аммониевые соединения в качестве добавок к топливу или смазочным материалам

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20052449A1 (it) 2005-12-22 2007-06-23 Cell Therapeutics Europe Srl Nuovi bis-platino complessi ad attivita' antitumorale
ITMI20081660A1 (it) * 2008-09-18 2010-03-19 Cell Therapeutics Inc Sede Secon Daria Complesso di platino ad attivita' antitumorale
WO2015140822A1 (en) * 2014-03-18 2015-09-24 Council Of Scientific & Industrial Research Halogen free ionic liquids as lubricant or lubricant additives and a process for the preparation thereof
GB201413355D0 (en) * 2014-07-28 2014-09-10 Innospec Ltd Compositons and methods
CN110075120B (zh) * 2018-10-11 2022-03-11 广东众尔健生物科技有限公司 一种组合物及其在抗肿瘤药物中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6296A (ja) * 1985-03-06 1987-01-06 Sumitomo Pharmaceut Co Ltd 脂溶性白金（２）錯体
IT1200467B (it) 1985-05-06 1989-01-18 Boehringer Biochemia Srl Formulazione farmaceutica
US5117022A (en) 1985-10-18 1992-05-26 The Board Of Regents, The University Of Texas System Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
JPS63501568A (ja) * 1985-10-18 1988-06-16 ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム リポソ−ムに有効に組み込まれた疎水性シス−プラチナ複合体
US5107007A (en) 1989-09-01 1992-04-21 The University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
US4797393A (en) 1986-07-25 1989-01-10 University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
EP0265719B1 (en) 1986-10-07 1991-03-06 Boehringer Mannheim Italia S.P.A. Pharmaceutical compositions having antineoplastic activity
ZA976421B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polyamine ligands as antitumor agents.
ZA976422B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
ITMI991508A1 (it) * 1999-07-09 2001-01-09 Novuspharma Spa Nitrati di bis-platino complessi con ligandi poliamminici
IT1313594B1 (it) * 1999-08-03 2002-09-09 Novuspharma Spa Bisplatino complessi attivi per via orale.
CA2457118A1 (en) 2001-08-22 2003-03-06 Virginia Commonwealth University Targeted bisplatinum polyamines as pro-drugs: selective release of platinum
EP1734937A1 (en) * 2004-03-26 2006-12-27 Cell Therapeutics Europe S.R.L. Nanoparticle formulations of platinum compounds
ITMI20052449A1 (it) 2005-12-22 2007-06-23 Cell Therapeutics Europe Srl Nuovi bis-platino complessi ad attivita' antitumorale

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2702130C2 (ru) * 2013-07-26 2019-10-04 Инноспек Лимитед Четвертичные аммониевые соединения в качестве добавок к топливу или смазочным материалам

Also Published As

Publication number Publication date
NO20082722L (no) 2008-09-17
EP1968991A1 (en) 2008-09-17
EA015619B1 (ru) 2011-10-31
MX2008007932A (es) 2008-09-11
JP5436862B2 (ja) 2014-03-05
AU2006328970A1 (en) 2007-06-28
IL192295A0 (en) 2008-12-29
WO2007071415A1 (en) 2007-06-28
ES2383432T9 (es) 2012-11-06
CA2634355A1 (en) 2007-06-28
AU2006328970B2 (en) 2012-11-29
EP1968991B9 (en) 2012-08-08
KR20080096643A (ko) 2008-10-31
BRPI0620065A2 (pt) 2011-11-01
ZA200805341B (en) 2009-10-28
ES2383432T3 (es) 2012-06-21
CN101341161A (zh) 2009-01-07
EP1968991B1 (en) 2012-01-18
CA2634355C (en) 2015-03-31
ITMI20052449A1 (it) 2007-06-23
US8426625B2 (en) 2013-04-23
US20100292322A1 (en) 2010-11-18
JP2009520731A (ja) 2009-05-28
NZ569258A (en) 2011-08-26
ATE541851T1 (de) 2012-02-15
KR101415094B1 (ko) 2014-08-06

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU