ZA200804421B - Process for the manufacture of iohexol - Google Patents

Process for the manufacture of iohexol

Info

Publication number
ZA200804421B
ZA200804421B ZA200804421A ZA200804421A ZA200804421B ZA 200804421 B ZA200804421 B ZA 200804421B ZA 200804421 A ZA200804421 A ZA 200804421A ZA 200804421 A ZA200804421 A ZA 200804421A ZA 200804421 B ZA200804421 B ZA 200804421B
Authority
ZA
South Africa
Prior art keywords
iohexol
base
manufacture
hydroxide
alkylating
Prior art date
Application number
ZA200804421A
Other languages
English (en)
Inventor
Bandarra Joao Antonio Moinho
Heggie William
Galindro Jose
Marto Susanna
Original Assignee
Hovione Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Int Ltd filed Critical Hovione Int Ltd
Publication of ZA200804421B publication Critical patent/ZA200804421B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
ZA200804421A 2005-11-24 2008-05-21 Process for the manufacture of iohexol ZA200804421B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT103391A PT103391B (pt) 2005-11-24 2005-11-24 Processo para fabrico de lohexol

Publications (1)

Publication Number Publication Date
ZA200804421B true ZA200804421B (en) 2009-03-25

Family

ID=36087809

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200804421A ZA200804421B (en) 2005-11-24 2008-05-21 Process for the manufacture of iohexol

Country Status (14)

Country Link
US (1) US7541494B2 (ja)
EP (1) EP1951657B1 (ja)
JP (1) JP5139993B2 (ja)
KR (1) KR101320436B1 (ja)
CN (1) CN101336228B (ja)
AT (1) ATE529396T1 (ja)
AU (1) AU2006318924B2 (ja)
BR (1) BRPI0620543A2 (ja)
ES (1) ES2375494T3 (ja)
NO (1) NO340888B1 (ja)
PL (1) PL1951657T3 (ja)
PT (1) PT103391B (ja)
WO (1) WO2007060380A1 (ja)
ZA (1) ZA200804421B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
EP2483235A1 (en) * 2009-09-30 2012-08-08 Mallinckrodt LLC Alkylation of triiodo-substituted arylamides in an aqueous mixed solvent system
US9474808B2 (en) * 2010-12-21 2016-10-25 Ge Healthcare As Desalination of a composition comprising a contrast agent
JP6571100B2 (ja) 2014-03-04 2019-09-04 大塚製薬株式会社 イオヘキソール粉末及びそれを使用する方法
CN107721875A (zh) * 2017-11-21 2018-02-23 苏州纳微科技有限公司 一种碘海醇的精纯方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
JPS5724378A (en) * 1980-07-22 1982-02-08 Dainippon Ink & Chem Inc Preparation of fluorine-containing epoxy compound
JPH07330711A (ja) * 1994-06-03 1995-12-19 Yoshitomi Pharmaceut Ind Ltd 高純度４，４’−チオビス（ジフェニルチオウレア）の製造法
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
PT101919B (pt) 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
IT1292037B1 (it) * 1997-05-30 1999-01-25 Bracco Spa Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
GB9725010D0 (en) * 1997-11-26 1998-01-28 Nycomed Imaging As Process
ITMI20010773A1 (it) 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
NO20033058D0 (no) 2003-07-03 2003-07-03 Amersham Health As Prosess

Also Published As

Publication number Publication date
BRPI0620543A2 (pt) 2011-11-16
JP2009517373A (ja) 2009-04-30
KR20090004842A (ko) 2009-01-12
ES2375494T3 (es) 2012-03-01
US7541494B2 (en) 2009-06-02
PT103391B (pt) 2008-10-30
PL1951657T3 (pl) 2012-03-30
US20090048463A1 (en) 2009-02-19
NO340888B1 (no) 2017-07-10
PT103391A (pt) 2007-05-31
ATE529396T1 (de) 2011-11-15
KR101320436B1 (ko) 2013-10-23
AU2006318924B2 (en) 2012-07-26
NO20082271L (no) 2008-08-12
CN101336228B (zh) 2013-06-12
AU2006318924A1 (en) 2007-05-31
JP5139993B2 (ja) 2013-02-06
EP1951657A1 (en) 2008-08-06
CN101336228A (zh) 2008-12-31
WO2007060380A1 (en) 2007-05-31
EP1951657B1 (en) 2011-10-19

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