ZA200710154B - Tigecycline and methods of preparing 9-aminominocycline - Google Patents
Tigecycline and methods of preparing 9-aminominocyclineInfo
- Publication number
- ZA200710154B ZA200710154B ZA200710154A ZA200710154A ZA200710154B ZA 200710154 B ZA200710154 B ZA 200710154B ZA 200710154 A ZA200710154 A ZA 200710154A ZA 200710154 A ZA200710154 A ZA 200710154A ZA 200710154 B ZA200710154 B ZA 200710154B
- Authority
- ZA
- South Africa
- Prior art keywords
- aminominocycline
- tigecycline
- preparing
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68514605P | 2005-05-27 | 2005-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200710154B true ZA200710154B (en) | 2009-05-27 |
Family
ID=37025920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200710154A ZA200710154B (en) | 2005-05-27 | 2007-11-26 | Tigecycline and methods of preparing 9-aminominocycline |
Country Status (21)
Country | Link |
---|---|
US (1) | US20070049563A1 (ko) |
EP (1) | EP1885686A2 (ko) |
JP (1) | JP2008545707A (ko) |
KR (1) | KR20080016894A (ko) |
CN (1) | CN101228113A (ko) |
AR (1) | AR057324A1 (ko) |
AU (1) | AU2006252686A1 (ko) |
BR (1) | BRPI0610649A2 (ko) |
CA (1) | CA2609649A1 (ko) |
CR (1) | CR9538A (ko) |
EC (1) | ECSP078056A (ko) |
GT (1) | GT200600222A (ko) |
IL (1) | IL187358A0 (ko) |
MX (1) | MX2007014734A (ko) |
NI (1) | NI200700300A (ko) |
NO (1) | NO20075998L (ko) |
PE (1) | PE20061447A1 (ko) |
RU (1) | RU2007143159A (ko) |
TW (1) | TW200716515A (ko) |
WO (1) | WO2006130500A2 (ko) |
ZA (1) | ZA200710154B (ko) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR057649A1 (es) * | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
EP2007713A2 (en) * | 2006-04-17 | 2008-12-31 | Teva Pharmaceutical Industries Ltd | Isolation of tetracycline derivatives |
EP2016045B1 (en) * | 2006-04-24 | 2014-10-29 | Teva Pharmaceutical Industries, Ltd. | A tigecycline crystalline form and processes for its preparation |
US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
EP2236491A3 (en) * | 2006-11-29 | 2010-11-03 | Teva Pharmaceutical Industries, Ltd. | Crystalline form of tigecycline and processes for preparation thereof |
EP2084126A1 (en) * | 2006-11-30 | 2009-08-05 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of 9-haloacetamidominocyclines |
WO2008106234A1 (en) * | 2007-03-01 | 2008-09-04 | Teva Pharmaceutical Industries Ltd. | Processes for purification of tigecycline |
US20090099376A1 (en) * | 2007-10-16 | 2009-04-16 | Wyeth | Tigecycline and methods of preparing intermediates |
CN101861300B (zh) * | 2007-11-14 | 2014-07-09 | 桑多斯股份公司 | 盐酸替吉环素的晶型 |
CA2746585C (en) | 2008-12-18 | 2017-08-29 | Sandoz Ag | Crystalline form c of tigecycline dihydrochloride and methods for its preparation |
WO2010114680A1 (en) | 2009-03-12 | 2010-10-07 | Wyeth Llc | Nitration of tetracyclines |
IT1393350B1 (it) * | 2009-03-16 | 2012-04-20 | Antibioticos Spa | Processo di preparazione di tigeciclina |
SI2327676T1 (sl) * | 2009-11-26 | 2014-07-31 | Sandoz Ag | Reakcije organskih spojin z nizkimi količinami vodika |
CN101919816B (zh) * | 2010-07-02 | 2012-07-25 | 赵军旭 | 一种含有替加环素的注射用无菌分装制剂 |
CN101973906B (zh) * | 2010-09-27 | 2014-03-19 | 重庆福安药业(集团)股份有限公司 | 一种替加环素无定形态的制备方法 |
CN101955443B (zh) * | 2010-09-30 | 2012-05-23 | 浙江大学 | 一种替加环素中间体及其盐的制备方法 |
CN102617395B (zh) * | 2011-01-29 | 2014-06-11 | 正大天晴药业集团股份有限公司 | 一种甘氨酰环素类抗生素的制备方法 |
CN103044280B (zh) * | 2012-12-20 | 2015-04-22 | 安徽悦康凯悦制药有限公司 | 替加环素的制备方法 |
US20160143925A1 (en) | 2013-11-12 | 2016-05-26 | Galenicum Health S.L. | Stable pharmaceutical compositions |
CN111855857B (zh) * | 2020-07-30 | 2022-07-26 | 武汉药品医疗器械检验所 | 一种盐酸米诺环素及其杂质的高效液相色谱检测方法 |
Family Cites Families (49)
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USRE26271E (en) * | 1967-09-26 | Reductive alkylation process | ||
US3026248A (en) * | 1959-09-11 | 1962-03-20 | Pfizer & Co C | Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents |
US3043875A (en) * | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
FR1430859A (ko) * | 1960-05-23 | 1966-05-25 | ||
US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
US3239499A (en) * | 1961-05-19 | 1966-03-08 | Pfizer & Co C | Tetracycline derivative |
US3502696A (en) * | 1961-08-18 | 1970-03-24 | Pfizer & Co C | Antibacterial agents |
US3148212A (en) * | 1961-12-22 | 1964-09-08 | American Cyanamid Co | Reductive alkylation process |
US3145228A (en) * | 1962-09-06 | 1964-08-18 | Pfizer & Co C | 5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof |
US3250809A (en) * | 1962-09-06 | 1966-05-10 | Pfizer & Co C | 6-deoxy-6-demethyl-6-halomethylene tetracyclines and their 11a-chloro and fluoro derivatives |
US3250810A (en) * | 1962-09-06 | 1966-05-10 | Pfizer & Co C | 6-hydroxy-6-halomethyl tetracyclines |
US3219529A (en) * | 1962-10-04 | 1965-11-23 | American Cyanamid Co | Stable tetracycline solutions |
USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
US3433834A (en) * | 1966-03-14 | 1969-03-18 | American Cyanamid Co | Nitration of 11a-chloro tetracyclines |
US3397230A (en) * | 1966-03-14 | 1968-08-13 | American Cyanamid Co | Nitration of tetracyclines |
US3341585A (en) * | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
US3849493A (en) * | 1966-08-01 | 1974-11-19 | Pfizer | D-ring substituted 6-deoxytetracyclines |
US3345410A (en) * | 1966-12-01 | 1967-10-03 | American Cyanamid Co | Substituted 7- and/or 9-amino tetracyclines |
US3373196A (en) * | 1967-03-21 | 1968-03-12 | American Cyanamid Co | 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines |
US3373197A (en) * | 1967-04-27 | 1968-03-12 | American Cyanamid Co | Substituted 6-epitetracyclines and 5a-epi-6-epitetracyclines |
US3373198A (en) * | 1967-04-27 | 1968-03-12 | American Cyanamid Co | Substituted 5a, 11a-dehydro-6-epitetracyclines |
US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
US3579579A (en) * | 1968-04-18 | 1971-05-18 | American Cyanamid Co | Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines |
US4038315A (en) * | 1972-05-11 | 1977-07-26 | American Cyanamid Company | Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride |
JPS5697277A (en) * | 1980-01-07 | 1981-08-05 | Takeda Chem Ind Ltd | Thiazolidine derivative |
US5202449A (en) * | 1987-07-28 | 1993-04-13 | Nippon Kayaku Kabushiki Kaisha | Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline |
US5141960A (en) * | 1991-06-25 | 1992-08-25 | G. D. Searle & Co. | Tricyclic glycinamide derivatives as anti-convulsants |
US5281628A (en) * | 1991-10-04 | 1994-01-25 | American Cyanamid Company | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines |
US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5248797A (en) * | 1992-08-13 | 1993-09-28 | American Cyanamid Company | Method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5371076A (en) * | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
AU1279095A (en) * | 1994-02-17 | 1995-09-04 | Pfizer Inc. | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
US5675030A (en) * | 1994-11-16 | 1997-10-07 | American Cyanamid Company | Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound |
US5843925A (en) * | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
US6946453B2 (en) * | 1998-11-18 | 2005-09-20 | Collagenex Pharmaceuticals, Inc. | 4-dedimethylaminotracycline derivatives |
US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
EP1263442A1 (en) * | 2000-01-24 | 2002-12-11 | Trustees Of Tufts College | TETRACYCLINE COMPOUNDS FOR TREATMENT OF i CRYPTOSPORIDIUM PARVUM /i RELATED DISORDERS |
CA2404628A1 (en) * | 2000-03-31 | 2001-10-11 | Stuart B. Levy | 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds |
IL153639A0 (en) * | 2000-07-07 | 2003-07-06 | Tufts College | 9-substituted minocycline compounds |
US6624168B2 (en) * | 2000-07-07 | 2003-09-23 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
CN1564690A (zh) * | 2001-10-05 | 2005-01-12 | 泰特拉吉尼克斯医药公司 | 四环素衍生物及其使用方法 |
UA83266C2 (en) * | 2003-12-08 | 2008-06-25 | Уайет | Oxazole derivatives of tetracyclines |
AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
-
2006
- 2006-05-24 AR ARP060102153A patent/AR057324A1/es unknown
- 2006-05-25 RU RU2007143159/04A patent/RU2007143159A/ru not_active Application Discontinuation
- 2006-05-25 CA CA002609649A patent/CA2609649A1/en not_active Abandoned
- 2006-05-25 CN CNA2006800269628A patent/CN101228113A/zh active Pending
- 2006-05-25 GT GT200600222A patent/GT200600222A/es unknown
- 2006-05-25 EP EP06771352A patent/EP1885686A2/en not_active Withdrawn
- 2006-05-25 AU AU2006252686A patent/AU2006252686A1/en not_active Abandoned
- 2006-05-25 PE PE2006000552A patent/PE20061447A1/es not_active Application Discontinuation
- 2006-05-25 WO PCT/US2006/020536 patent/WO2006130500A2/en active Application Filing
- 2006-05-25 MX MX2007014734A patent/MX2007014734A/es not_active Application Discontinuation
- 2006-05-25 KR KR1020077030616A patent/KR20080016894A/ko not_active Application Discontinuation
- 2006-05-25 TW TW095118578A patent/TW200716515A/zh unknown
- 2006-05-25 JP JP2008513773A patent/JP2008545707A/ja not_active Withdrawn
- 2006-05-25 BR BRPI0610649-8A patent/BRPI0610649A2/pt not_active IP Right Cessation
- 2006-05-25 US US11/440,038 patent/US20070049563A1/en not_active Abandoned
-
2007
- 2007-11-14 IL IL187358A patent/IL187358A0/en unknown
- 2007-11-22 CR CR9538A patent/CR9538A/es not_active Application Discontinuation
- 2007-11-22 NI NI200700300A patent/NI200700300A/es unknown
- 2007-11-23 NO NO20075998A patent/NO20075998L/no not_active Application Discontinuation
- 2007-11-26 ZA ZA200710154A patent/ZA200710154B/xx unknown
- 2007-12-26 EC EC2007008056A patent/ECSP078056A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2008545707A (ja) | 2008-12-18 |
CR9538A (es) | 2008-02-20 |
WO2006130500A8 (en) | 2008-01-10 |
KR20080016894A (ko) | 2008-02-22 |
WO2006130500A3 (en) | 2007-01-18 |
IL187358A0 (en) | 2008-04-13 |
TW200716515A (en) | 2007-05-01 |
ECSP078056A (es) | 2008-01-23 |
NO20075998L (no) | 2008-02-19 |
MX2007014734A (es) | 2008-02-15 |
EP1885686A2 (en) | 2008-02-13 |
AU2006252686A1 (en) | 2006-12-07 |
CA2609649A1 (en) | 2006-12-07 |
WO2006130500A2 (en) | 2006-12-07 |
NI200700300A (es) | 2008-07-03 |
RU2007143159A (ru) | 2009-07-10 |
BRPI0610649A2 (pt) | 2010-07-13 |
US20070049563A1 (en) | 2007-03-01 |
CN101228113A (zh) | 2008-07-23 |
AR057324A1 (es) | 2007-11-28 |
GT200600222A (es) | 2007-01-12 |
PE20061447A1 (es) | 2007-01-22 |
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