ZA200705783B - Amino-imidazolones for the inhibition of ß-secretase - Google Patents

Amino-imidazolones for the inhibition of ß-secretase

Info

Publication number
ZA200705783B
ZA200705783B ZA200705783A ZA200705783A ZA200705783B ZA 200705783 B ZA200705783 B ZA 200705783B ZA 200705783 A ZA200705783 A ZA 200705783A ZA 200705783 A ZA200705783 A ZA 200705783A ZA 200705783 B ZA200705783 B ZA 200705783B
Authority
ZA
South Africa
Prior art keywords
imidazolones
secretase
inhibition
amino
Prior art date
Application number
ZA200705783A
Other languages
English (en)
Inventor
Malamas Michael Sotirios
Gunawan Iwan Suwandi
Harrison Boyd Lynn
Erdei James Joseph
Nowak Pawel
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ZA200705783B publication Critical patent/ZA200705783B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200705783A 2005-01-14 2007-07-13 Amino-imidazolones for the inhibition of ß-secretase ZA200705783B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64380505P 2005-01-14 2005-01-14

Publications (1)

Publication Number Publication Date
ZA200705783B true ZA200705783B (en) 2008-09-25

Family

ID=36581776

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200705783A ZA200705783B (en) 2005-01-14 2007-07-13 Amino-imidazolones for the inhibition of ß-secretase

Country Status (20)

Country Link
US (2) US7563796B2 (es)
EP (2) EP2264036A1 (es)
JP (1) JP2008526966A (es)
KR (1) KR20070095948A (es)
CN (1) CN101103034A (es)
AR (1) AR052458A1 (es)
AU (1) AU2006205127A1 (es)
BR (1) BRPI0606690A2 (es)
CA (1) CA2593515A1 (es)
CR (1) CR9244A (es)
GT (1) GT200600009A (es)
IL (1) IL183938A0 (es)
MX (1) MX2007008555A (es)
NO (1) NO20073099L (es)
PA (1) PA8660001A1 (es)
PE (1) PE20060842A1 (es)
RU (1) RU2007126570A (es)
TW (1) TW200637866A (es)
WO (1) WO2006076284A2 (es)
ZA (1) ZA200705783B (es)

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US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
MXPA06014792A (es) 2004-06-16 2007-02-16 Wyeth Corp Difenilimidazopirimidina y aminas imidazol como inhibidores de ??-secretasa.
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TW200738683A (en) * 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
AU2006266167A1 (en) * 2005-06-30 2007-01-11 Wyeth Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
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CA2623245A1 (en) * 2005-09-26 2007-04-05 Wyeth Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace)
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WO2007100536A1 (en) * 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
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TW200815447A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds IV
TW200815449A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds II
TW200815443A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds I
TW200808796A (en) * 2006-06-14 2008-02-16 Astrazeneca Ab New compounds III
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US7700606B2 (en) * 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
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CN103415521B (zh) * 2011-03-09 2016-01-06 詹森药业有限公司 用作β分泌酶（BACE）抑制剂的3,4-二氢-吡咯并[1,2-a]吡嗪-1-基胺衍生物
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Also Published As

Publication number Publication date
BRPI0606690A2 (pt) 2009-07-14
IL183938A0 (en) 2007-10-31
CA2593515A1 (en) 2006-07-20
US7563796B2 (en) 2009-07-21
CR9244A (es) 2007-09-07
EP2264036A1 (en) 2010-12-22
CN101103034A (zh) 2008-01-09
AR052458A1 (es) 2007-03-21
PA8660001A1 (es) 2006-09-08
JP2008526966A (ja) 2008-07-24
NO20073099L (no) 2007-07-31
WO2006076284A3 (en) 2007-04-19
EP1836208A2 (en) 2007-09-26
PE20060842A1 (es) 2006-10-12
MX2007008555A (es) 2007-11-21
AU2006205127A1 (en) 2006-07-20
KR20070095948A (ko) 2007-10-01
RU2007126570A (ru) 2009-02-20
US20090253716A1 (en) 2009-10-08
WO2006076284A2 (en) 2006-07-20
TW200637866A (en) 2006-11-01
US20060160828A1 (en) 2006-07-20
GT200600009A (es) 2006-08-17

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