ZA200705075B - Novel hydantoin derivatives as metalloproteinase inhibitors - Google Patents

Novel hydantoin derivatives as metalloproteinase inhibitors

Info

Publication number
ZA200705075B
ZA200705075B ZA200705075A ZA200705075A ZA200705075B ZA 200705075 B ZA200705075 B ZA 200705075B ZA 200705075 A ZA200705075 A ZA 200705075A ZA 200705075 A ZA200705075 A ZA 200705075A ZA 200705075 B ZA200705075 B ZA 200705075B
Authority
ZA
South Africa
Prior art keywords
metalloproteinase inhibitors
hydantoin derivatives
novel hydantoin
novel
derivatives
Prior art date
Application number
ZA200705075A
Other languages
English (en)
Inventor
Gabos Balint
Munck Af Rosenschoeld Magnus
Zlatoidsky Pavol
Lundkvist Michael
Shamovsky Igor
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200705075B publication Critical patent/ZA200705075B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200705075A 2004-12-17 2007-06-12 Novel hydantoin derivatives as metalloproteinase inhibitors ZA200705075B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0403085A SE0403085D0 (sv) 2004-12-17 2004-12-17 Novel componds

Publications (1)

Publication Number Publication Date
ZA200705075B true ZA200705075B (en) 2008-12-31

Family

ID=34075235

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200705075A ZA200705075B (en) 2004-12-17 2007-06-12 Novel hydantoin derivatives as metalloproteinase inhibitors

Country Status (23)

Country Link
US (2) US7655664B2 (enExample)
EP (1) EP1831199B1 (enExample)
JP (1) JP2008524210A (enExample)
KR (1) KR20070090924A (enExample)
CN (1) CN101119987A (enExample)
AR (1) AR051795A1 (enExample)
AT (1) ATE545642T1 (enExample)
AU (1) AU2005317286B2 (enExample)
BR (1) BRPI0517035A (enExample)
CA (1) CA2590845A1 (enExample)
ES (1) ES2380670T3 (enExample)
IL (1) IL183599A (enExample)
MX (1) MX2007007023A (enExample)
MY (1) MY147770A (enExample)
NO (1) NO20073572L (enExample)
NZ (1) NZ555831A (enExample)
RU (1) RU2376301C2 (enExample)
SA (1) SA05260409B1 (enExample)
SE (1) SE0403085D0 (enExample)
TW (1) TW200635917A (enExample)
UA (1) UA90285C2 (enExample)
WO (1) WO2006065215A1 (enExample)
ZA (1) ZA200705075B (enExample)

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SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
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US7648992B2 (en) * 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
WO2006099598A2 (en) * 2005-03-16 2006-09-21 Sensus Metering Systems Inc. Determining a physical location of a sensor
CA2606760C (en) * 2005-05-04 2014-12-23 Renovis, Inc. Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and disfunctions
TW200740769A (en) * 2006-03-16 2007-11-01 Astrazeneca Ab Novel process
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
KR101271219B1 (ko) * 2011-01-27 2013-06-07 광주과학기술원 신규한 하이단토인 유도체 및 이의 용도
EP3089974B1 (en) * 2013-12-31 2019-02-20 Ipsen Pharma S.A.S. Novel imidazolidine-2,4-dione derivatives
US20200268728A1 (en) 2016-12-20 2020-08-27 Sumitomo Dainippon Pharma Co., Ltd. Drug targeting cancer stem cell
JP2023520647A (ja) 2020-03-26 2023-05-18 リヒター ゲデオン ニュイルヴァーノシャン ミューコェデー レースヴェーニュタールシャシャーグ ＧＡＢＡ Ａアルファ５受容体調節剤としてのナフチリジンおよびピリド［３，４－ｃ］ピリダジン誘導体
CA3244639A1 (en) 2021-12-28 2025-06-13 Nippon Shinyaku Co., Ltd. Indazole compound and pharmaceutical
CN119255801A (zh) * 2022-05-30 2025-01-03 赛诺哈勃药业（成都）有限公司 四氢萘啶衍生物在制备防治粘连相关疾病的药物中的应用

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SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
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SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
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Also Published As

Publication number Publication date
WO2006065215A1 (en) 2006-06-22
US20080293743A1 (en) 2008-11-27
BRPI0517035A (pt) 2008-09-30
ATE545642T1 (de) 2012-03-15
AU2005317286A1 (en) 2006-06-22
US7655664B2 (en) 2010-02-02
CA2590845A1 (en) 2006-06-22
TW200635917A (en) 2006-10-16
SE0403085D0 (sv) 2004-12-17
SA05260409B1 (ar) 2009-03-14
NZ555831A (en) 2011-01-28
KR20070090924A (ko) 2007-09-06
UA90285C2 (ru) 2010-04-26
MY147770A (en) 2013-01-31
CN101119987A (zh) 2008-02-06
ES2380670T3 (es) 2012-05-17
EP1831199A1 (en) 2007-09-12
NO20073572L (no) 2007-09-12
IL183599A0 (en) 2007-09-20
MX2007007023A (es) 2007-09-11
RU2007126746A (ru) 2009-01-27
IL183599A (en) 2012-02-29
JP2008524210A (ja) 2008-07-10
AR051795A1 (es) 2007-02-07
US20100256166A1 (en) 2010-10-07
EP1831199B1 (en) 2012-02-15
AU2005317286B2 (en) 2009-02-05
RU2376301C2 (ru) 2009-12-20

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