MX2007007023A - Nuevos derivados de hidantoina como inhibidores de metaloproteinasa. - Google Patents
Nuevos derivados de hidantoina como inhibidores de metaloproteinasa.Info
- Publication number
- MX2007007023A MX2007007023A MX2007007023A MX2007007023A MX2007007023A MX 2007007023 A MX2007007023 A MX 2007007023A MX 2007007023 A MX2007007023 A MX 2007007023A MX 2007007023 A MX2007007023 A MX 2007007023A MX 2007007023 A MX2007007023 A MX 2007007023A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compound
- cyclopropyl
- pharmaceutically acceptable
- methyl
- Prior art date
Links
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- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 description 10
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61P35/00—Antineoplastic agents
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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Publications (1)
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| MX2007007023A true MX2007007023A (es) | 2007-09-11 |
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| SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
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| US7945626B2 (en) * | 2005-03-16 | 2011-05-17 | M&Fc Holding, Llc | Method, system, apparatus, and computer program product for determining a physical location of a sensor |
| JP5198256B2 (ja) * | 2005-05-04 | 2013-05-15 | エボテク エージー | 縮合複素環式化合物、並びにそれらの組成物及び使用 |
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| KR101271219B1 (ko) * | 2011-01-27 | 2013-06-07 | 광주과학기술원 | 신규한 하이단토인 유도체 및 이의 용도 |
| ES2725881T3 (es) * | 2013-12-31 | 2019-09-30 | Ipsen Pharma Sas | Nuevos derivados de imidazolidin-2,4-diona |
| US20200268728A1 (en) | 2016-12-20 | 2020-08-27 | Sumitomo Dainippon Pharma Co., Ltd. | Drug targeting cancer stem cell |
| TWI901650B (zh) | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
| US12649738B2 (en) | 2020-03-26 | 2026-06-09 | Richter Gedeon Nyrt. | 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine derivatives as GABAA α5 receptor modulators |
| CN118748993A (zh) | 2021-12-28 | 2024-10-08 | 日本新药株式会社 | 吲唑化合物和药物 |
| US20260151410A1 (en) * | 2022-05-30 | 2026-06-04 | Scinnohub Pharmaceutical Co., Ltd | Tetrahydronaphthyridine Derivatives, Medicine Prepared Therefrom, and Applications Thereof in Preventing and Treating Adhesion-related Diseases |
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| DK1001930T3 (da) | 1997-07-31 | 2003-03-24 | Abbott Lab | N-hydroxyformamidderivater som inhibitorer af matrix-metalloproteinaser |
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| WO1999024399A1 (en) | 1997-11-12 | 1999-05-20 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| PL342009A1 (en) | 1998-02-04 | 2001-05-07 | Novartis Ag | Sulphonylamine derivatives capable to inhibit extracellular substance degrading metaloproteinases |
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| SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| ATE445400T1 (de) | 2001-05-25 | 2009-10-15 | Bristol Myers Squibb Co | Hydantion-derivate als hemmer von matrix- metalloproteinasen |
| GB0114004D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| SE0103710D0 (sv) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
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| TWI220073B (en) | 2003-07-24 | 2004-08-01 | Au Optronics Corp | Method for manufacturing polysilicon film |
| SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| SE0401763D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Compounds |
| US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| SE0403085D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| TW200740769A (en) | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
| TW200831488A (en) | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
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2004
- 2004-12-17 SE SE0403085A patent/SE0403085D0/sv unknown
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2005
- 2005-12-14 EP EP05815745A patent/EP1831199B1/en not_active Expired - Lifetime
- 2005-12-14 NZ NZ555831A patent/NZ555831A/en not_active IP Right Cessation
- 2005-12-14 US US11/721,586 patent/US7655664B2/en not_active Expired - Fee Related
- 2005-12-14 CN CNA2005800481778A patent/CN101119987A/zh active Pending
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- 2005-12-14 CA CA002590845A patent/CA2590845A1/en not_active Abandoned
- 2005-12-14 RU RU2007126746/04A patent/RU2376301C2/ru not_active IP Right Cessation
- 2005-12-14 KR KR1020077013489A patent/KR20070090924A/ko not_active Ceased
- 2005-12-14 JP JP2007546609A patent/JP2008524210A/ja active Pending
- 2005-12-14 AT AT05815745T patent/ATE545642T1/de active
- 2005-12-14 ES ES05815745T patent/ES2380670T3/es not_active Expired - Lifetime
- 2005-12-14 BR BRPI0517035-4A patent/BRPI0517035A/pt not_active IP Right Cessation
- 2005-12-14 WO PCT/SE2005/001917 patent/WO2006065215A1/en not_active Ceased
- 2005-12-14 MX MX2007007023A patent/MX2007007023A/es active IP Right Grant
- 2005-12-14 UA UAA200706657A patent/UA90285C2/ru unknown
- 2005-12-15 AR ARP050105273A patent/AR051795A1/es not_active Application Discontinuation
- 2005-12-15 MY MYPI20055915A patent/MY147770A/en unknown
- 2005-12-16 TW TW094144602A patent/TW200635917A/zh unknown
- 2005-12-17 SA SA05260409A patent/SA05260409B1/ar unknown
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2007
- 2007-05-31 IL IL183599A patent/IL183599A/en not_active IP Right Cessation
- 2007-06-12 ZA ZA200705075A patent/ZA200705075B/xx unknown
- 2007-07-10 NO NO20073572A patent/NO20073572L/no not_active Application Discontinuation
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2010
- 2010-02-01 US US12/697,625 patent/US20100256166A1/en not_active Abandoned
Also Published As
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| US20080293743A1 (en) | 2008-11-27 |
| BRPI0517035A (pt) | 2008-09-30 |
| EP1831199B1 (en) | 2012-02-15 |
| CN101119987A (zh) | 2008-02-06 |
| NO20073572L (no) | 2007-09-12 |
| NZ555831A (en) | 2011-01-28 |
| UA90285C2 (ru) | 2010-04-26 |
| US7655664B2 (en) | 2010-02-02 |
| EP1831199A1 (en) | 2007-09-12 |
| KR20070090924A (ko) | 2007-09-06 |
| IL183599A0 (en) | 2007-09-20 |
| WO2006065215A1 (en) | 2006-06-22 |
| CA2590845A1 (en) | 2006-06-22 |
| AU2005317286B2 (en) | 2009-02-05 |
| ES2380670T3 (es) | 2012-05-17 |
| TW200635917A (en) | 2006-10-16 |
| JP2008524210A (ja) | 2008-07-10 |
| ZA200705075B (en) | 2008-12-31 |
| MY147770A (en) | 2013-01-31 |
| AR051795A1 (es) | 2007-02-07 |
| SA05260409B1 (ar) | 2009-03-14 |
| RU2007126746A (ru) | 2009-01-27 |
| ATE545642T1 (de) | 2012-03-15 |
| AU2005317286A1 (en) | 2006-06-22 |
| US20100256166A1 (en) | 2010-10-07 |
| SE0403085D0 (sv) | 2004-12-17 |
| RU2376301C2 (ru) | 2009-12-20 |
| IL183599A (en) | 2012-02-29 |
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