ZA200704532B - Process for the preparation of 4-(6-chloro-2, 3-methylene-dioxyanilino)-7-[2-(4-methyl piperazin-1-yl) ethoxy]-5-tetrahydropyran-4-yloxyquinazoline, their intermediates and crystalline salts thereof - Google Patents

Info

Publication number

ZA200704532B

ZA200704532B ZA200704532A ZA200704532A ZA200704532B ZA 200704532 B ZA200704532 B ZA 200704532B ZA 200704532 A ZA200704532 A ZA 200704532A ZA 200704532 A ZA200704532 A ZA 200704532A ZA 200704532 B ZA200704532 B ZA 200704532B

Authority

ZA

South Africa

Prior art keywords

formula

compound

azd0530

salt

quinazoline

Prior art date

2004-12-17

Links

• Espacenet
• Global Dossier
• Discuss

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• 150000003839 salts Chemical class 0.000 title claims description 83
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• OQXMMAQEMJUIQM-LVEZLNDCSA-N (e)-but-2-enedioic acid;n-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine Chemical compound OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.C1CN(C)CCN1CCOC1=CC(OC2CCOCC2)=C(C(NC=2C(=CC=C3OCOC3=2)Cl)=NC=N2)C2=C1 OQXMMAQEMJUIQM-LVEZLNDCSA-N 0.000 claims description 43
• JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims description 40
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• 230000008018 melting Effects 0.000 claims description 24
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• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 16
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