BRPI0519085A2 - processos para a fabricaÇço de azd0530 e para a fabricaÇço de uma quinazolina, intermediÁrio, processo para a fabricaÇço de quinazolinona, forma cristalina substancialmente homogÊnea de 4-(6-cloro 2, 3-metileno-diàxi-anilino) - 7 - {2- (4-metil-piperazin -1- il) - etàxi} - 5 - tetraidropiran - 4-il- àxi - quinazolina, e, composiÇço farmacÊutica - Google Patents

processos para a fabricaÇço de azd0530 e para a fabricaÇço de uma quinazolina, intermediÁrio, processo para a fabricaÇço de quinazolinona, forma cristalina substancialmente homogÊnea de 4-(6-cloro 2, 3-metileno-diàxi-anilino) - 7 - {2- (4-metil-piperazin -1- il) - etàxi} - 5 - tetraidropiran - 4-il- àxi - quinazolina, e, composiÇço farmacÊutica

Info

Publication number
BRPI0519085A2
BRPI0519085A2 BRPI0519085-1A BRPI0519085A BRPI0519085A2 BR PI0519085 A2 BRPI0519085 A2 BR PI0519085A2 BR PI0519085 A BRPI0519085 A BR PI0519085A BR PI0519085 A2 BRPI0519085 A2 BR PI0519085A2
Authority
BR
Brazil
Prior art keywords
manufacture
quinazoline
processes
piperazin
chloro
Prior art date
Application number
BRPI0519085-1A
Other languages
English (en)
Inventor
James Gair Ford
James Francis Mccabe
Anne O'kearney-Mcmullan
Philip O'keefe
Simon Mark Pointon
Lyn Powell
Mark Purdie
Jane Withnall
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0519085A2 publication Critical patent/BRPI0519085A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCESSOS PARA A FABRICAÇçO DE AZDO53O E PARA A FABRICAÇçO DE UMA QUINAZOLINA, INTERMEDIÁRIO, PROCESSO PARA A FABRICAÇçO DE QUINAZOLINONA, FORMA CRISTALINA SUBSTANCIALMENTE HOMOGÊNEA DE 4-(6- CLORO-2,3 -METILENO-DIàXI-ANILINO)-7- [2-(4-METIL-PIPERAZIN- 1 -IL)-ETàXI]-5-TETRAIDROPIRAN-4-IL-àXI-QUINAZOLINA, E, COMPOSIÇçO FARMACÊUTICA. A presente invenção refere-se aos processos químicos úteis na fabricação do composto 4-(6-cloro-2,3 -metileno-dióxi-anilino)-7- [2-(4-metil- piperazin- 1 -il)-etóxi]-5-tetraidropiran-4-il-óxi-quinazolina (a entidade ativa dentro de AZDO53O), aos intermediários úteis na fabricação daquele composto e aos processos para a fabricação daqueles intermediários. A invenção também se refere às formas cristalinas específicas daquele composto tal como um sal de difumarato e um tri-hidrato e às composições farmacêuticas contendo tais formas cristalinas.
BRPI0519085-1A 2004-12-17 2005-12-14 processos para a fabricaÇço de azd0530 e para a fabricaÇço de uma quinazolina, intermediÁrio, processo para a fabricaÇço de quinazolinona, forma cristalina substancialmente homogÊnea de 4-(6-cloro 2, 3-metileno-diàxi-anilino) - 7 - {2- (4-metil-piperazin -1- il) - etàxi} - 5 - tetraidropiran - 4-il- àxi - quinazolina, e, composiÇço farmacÊutica BRPI0519085A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0427697.8A GB0427697D0 (en) 2004-12-17 2004-12-17 Chemical process
PCT/GB2005/004807 WO2006064217A2 (en) 2004-12-17 2005-12-14 PROCESS FOR THE PREPARATION OF 4-(6-CHLORO-2, 3-METHYLENEDIOXYANILINO)-7-[2-(4-METHYLPIPERAZIN-l-YL) ETHOXY]-5-TETRAHYDROPYRAN-4-YLOXYQUINAZOLINE , THEIR INTERMEDIATES AND CRYSTALLINE SALTS THEREOF

Publications (1)

Publication Number Publication Date
BRPI0519085A2 true BRPI0519085A2 (pt) 2008-12-23

Family

ID=34090249

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519085-1A BRPI0519085A2 (pt) 2004-12-17 2005-12-14 processos para a fabricaÇço de azd0530 e para a fabricaÇço de uma quinazolina, intermediÁrio, processo para a fabricaÇço de quinazolinona, forma cristalina substancialmente homogÊnea de 4-(6-cloro 2, 3-metileno-diàxi-anilino) - 7 - {2- (4-metil-piperazin -1- il) - etàxi} - 5 - tetraidropiran - 4-il- àxi - quinazolina, e, composiÇço farmacÊutica

Country Status (16)

Country Link
US (1) US8304417B2 (pt)
EP (1) EP1871769B1 (pt)
JP (2) JP5161584B2 (pt)
KR (6) KR20080094849A (pt)
CN (1) CN101115744B (pt)
AU (2) AU2005315458B2 (pt)
BR (1) BRPI0519085A2 (pt)
CA (2) CA2590735C (pt)
ES (1) ES2622480T3 (pt)
GB (1) GB0427697D0 (pt)
IL (1) IL183525A0 (pt)
MX (1) MX2007007210A (pt)
NO (1) NO20072755L (pt)
NZ (1) NZ555468A (pt)
WO (1) WO2006064217A2 (pt)
ZA (1) ZA200704532B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0412074D0 (en) 2004-05-29 2004-06-30 Astrazeneca Ab Combination product
WO2009068906A2 (en) * 2007-11-26 2009-06-04 Astrazeneca Ab Combinations comprising zd4054 and a src family kinase inhibitor 172
CN103275072B (zh) * 2013-05-22 2016-01-20 苏州明锐医药科技有限公司 塞卡替尼的制备方法
US10660957B2 (en) * 2013-06-13 2020-05-26 Yale University Compositions and methods for treating an Aβ-modulated disease or disorder or improving cognition in a subject
US11241434B2 (en) 2013-06-13 2022-02-08 Yale Uninversity Compositions and methods for improving cognition in a subject
US10369152B2 (en) 2015-02-13 2019-08-06 The Brigham And Women's Hospital, Inc. Methods and compositions for the treatment or prevention of abnormal bone formation in a soft tissue
US20220117966A1 (en) 2019-02-27 2022-04-21 Astrazeneca Ab Method of treating fibrosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73993C2 (uk) * 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
BR0113358A (pt) 2000-08-21 2003-07-01 Astrazeneca Ab Derivado de quinazolina ou de um seu sal farmaceuticamente aceitável, processo para a sua preparação, composição farmacêutica, e, uso do derivado ou de um seu sal farmaceuticamente aceitável
WO2002085895A1 (en) 2001-04-19 2002-10-31 Astrazeneca Ab Quinazoline derivatives
SI1562955T1 (sl) * 2002-11-04 2008-06-30 Astrazeneca Ab Derivati kinazolina kot inhibitorji Src-triozin kinaze
GB0226434D0 (en) * 2002-11-13 2002-12-18 Astrazeneca Ab Combination product
GB0307333D0 (en) 2003-03-29 2003-05-07 Astrazeneca Ab Therapeutic agent
GB0309850D0 (en) 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
GB0310401D0 (en) 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent

Also Published As

Publication number Publication date
WO2006064217A2 (en) 2006-06-22
WO2006064217A3 (en) 2006-12-21
NZ555468A (en) 2010-12-24
AU2005315458B2 (en) 2009-03-12
US20090099196A1 (en) 2009-04-16
JP2008524183A (ja) 2008-07-10
EP1871769B1 (en) 2017-02-22
US8304417B2 (en) 2012-11-06
WO2006064217A8 (en) 2007-07-05
KR20080094848A (ko) 2008-10-24
MX2007007210A (es) 2007-11-07
KR20070090004A (ko) 2007-09-04
KR20080094847A (ko) 2008-10-24
JP5161584B2 (ja) 2013-03-13
KR20110114727A (ko) 2011-10-19
KR20080094849A (ko) 2008-10-24
IL183525A0 (en) 2007-09-20
EP1871769A2 (en) 2008-01-02
JP2009143920A (ja) 2009-07-02
KR20080094846A (ko) 2008-10-24
AU2005315458A1 (en) 2006-06-22
ES2622480T3 (es) 2017-07-06
CN101115744A (zh) 2008-01-30
NO20072755L (no) 2007-07-02
CN101115744B (zh) 2012-02-01
ZA200704532B (en) 2008-07-30
AU2009200622A1 (en) 2009-03-12
GB0427697D0 (en) 2005-01-19
CA2675642A1 (en) 2006-06-22
CA2590735A1 (en) 2006-06-22
CA2590735C (en) 2009-11-10

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.