ZA200700681B - Use of ALK 5 inhibitors to modulate or inhibit myostatin activity leading to increased lean tissue accretion in animals - Google Patents
Use of ALK 5 inhibitors to modulate or inhibit myostatin activity leading to increased lean tissue accretion in animals Download PDFInfo
- Publication number
- ZA200700681B ZA200700681B ZA200700681A ZA200700681A ZA200700681B ZA 200700681 B ZA200700681 B ZA 200700681B ZA 200700681 A ZA200700681 A ZA 200700681A ZA 200700681 A ZA200700681 A ZA 200700681A ZA 200700681 B ZA200700681 B ZA 200700681B
- Authority
- ZA
- South Africa
- Prior art keywords
- imidazol
- pyridin
- benzo
- dioxol
- benzamide
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59235904P | 2004-07-29 | 2004-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200700681B true ZA200700681B (en) | 2008-07-30 |
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|---|---|---|---|
| ZA200700681A ZA200700681B (en) | 2004-07-29 | 2007-01-24 | Use of ALK 5 inhibitors to modulate or inhibit myostatin activity leading to increased lean tissue accretion in animals |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060194845A1 (fr) |
| EP (1) | EP1771171A1 (fr) |
| JP (1) | JP2008506787A (fr) |
| CN (1) | CN101031294A (fr) |
| AR (1) | AR050187A1 (fr) |
| AU (1) | AU2005280496B2 (fr) |
| BR (1) | BRPI0513914A (fr) |
| CA (1) | CA2576734C (fr) |
| MX (1) | MX2007001118A (fr) |
| NO (1) | NO20071113L (fr) |
| PE (1) | PE20060729A1 (fr) |
| TW (1) | TW200616621A (fr) |
| WO (1) | WO2006025988A1 (fr) |
| ZA (1) | ZA200700681B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008071605A2 (fr) * | 2006-12-15 | 2008-06-19 | F. Hoffmann-La Roche Ag | Méthodes de traitement de maladies inflammatoires |
| US20100144865A1 (en) * | 2007-05-04 | 2010-06-10 | Jana Pickova | Compound feed for aquaculture |
| GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| PL2170396T3 (pl) | 2007-08-03 | 2017-07-31 | Summit (Oxford) Limited | Kombinacje leków do leczenia dystrofii mięśniowej Duchenne'a |
| WO2009047163A1 (fr) * | 2007-10-10 | 2009-04-16 | F. Hoffmann-La Roche Ag | Procédés de traitement de maladies inflammatoires |
| CN101684457B (zh) * | 2009-07-27 | 2013-01-09 | 中国科学院广州生物医药与健康研究院 | I型转化生长因子受体抑制剂在产生诱导多能干细胞中的应用及其方法 |
| CA2831827A1 (fr) * | 2011-04-05 | 2012-10-11 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Composes et procedes pour la modification de la signalisation par kinase du type du recepteur d'activine |
| WO2013137832A1 (fr) * | 2012-03-16 | 2013-09-19 | Nanyang Technological University | Inhibiteurs de myostatine |
| EP3711771A1 (fr) | 2012-08-01 | 2020-09-23 | Ikaika Therapeutics, LLC | Atténuation de lésions tissulaires et de la fibrose par l'intermédiaire de la protéine de liaison bêta (ltbp4) d'un facteur de croissance de transformation latente |
| WO2016025629A1 (fr) | 2014-08-12 | 2016-02-18 | The Regents Of The University Of California | Composition moléculaire permettant d'améliorer et de renouveler l'entretien et la réparation des tissus de mammifère |
| KR102434226B1 (ko) | 2016-06-30 | 2022-08-19 | 한미약품 주식회사 | Alk5 억제제로서의 신규 피라졸 유도체 및 이의 용도 |
| JP2022511112A (ja) | 2018-12-11 | 2022-01-28 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | Ａｌｋ５阻害剤としてのナフチリジンおよびキノリン誘導体 |
| AU2019406214A1 (en) | 2018-12-21 | 2021-08-05 | Northwestern University | Use of annexins in preventing and treating muscle membrane injury |
| US20220062299A1 (en) | 2018-12-26 | 2022-03-03 | Northwestern University | Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder |
| AU2020385400A1 (en) | 2019-11-22 | 2022-06-09 | Theravance Biopharma R&D Ip, Llc | Substituted 1,5-naphthyridines or quinolines as ALK5 inhibitors |
| WO2022104071A2 (fr) * | 2020-11-13 | 2022-05-19 | The Jackson Laboratory | Agents thérapeutiques ciblant la signalisation de la famille bêta du facteur de croissance transformant |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| EP1147413B1 (fr) * | 1999-01-21 | 2006-04-05 | Metamorphix, Inc. | Inhibiteurs de facteurs de differenciation de la croissance et leurs utilisations |
| ES2187473T3 (es) * | 1999-04-09 | 2003-06-16 | Smithkline Beecham Corp | Triarylimidazoles. |
| GB0007405D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
-
2005
- 2005-07-27 EP EP05810799A patent/EP1771171A1/fr not_active Withdrawn
- 2005-07-27 US US11/190,453 patent/US20060194845A1/en not_active Abandoned
- 2005-07-27 AR ARP050103119A patent/AR050187A1/es not_active Application Discontinuation
- 2005-07-27 CN CNA2005800331272A patent/CN101031294A/zh active Pending
- 2005-07-27 PE PE2005000882A patent/PE20060729A1/es not_active Application Discontinuation
- 2005-07-27 BR BRPI0513914-7A patent/BRPI0513914A/pt not_active IP Right Cessation
- 2005-07-27 JP JP2007522848A patent/JP2008506787A/ja active Pending
- 2005-07-27 AU AU2005280496A patent/AU2005280496B2/en not_active Ceased
- 2005-07-27 WO PCT/US2005/026607 patent/WO2006025988A1/fr active Application Filing
- 2005-07-27 MX MX2007001118A patent/MX2007001118A/es not_active Application Discontinuation
- 2005-07-27 CA CA2576734A patent/CA2576734C/fr not_active Expired - Fee Related
- 2005-07-28 TW TW094125600A patent/TW200616621A/zh unknown
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2007
- 2007-01-24 ZA ZA200700681A patent/ZA200700681B/en unknown
- 2007-02-27 NO NO20071113A patent/NO20071113L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005280496B2 (en) | 2009-10-08 |
| WO2006025988A1 (fr) | 2006-03-09 |
| PE20060729A1 (es) | 2006-08-12 |
| CN101031294A (zh) | 2007-09-05 |
| CA2576734A1 (fr) | 2006-03-09 |
| NO20071113L (no) | 2007-02-27 |
| TW200616621A (en) | 2006-06-01 |
| US20060194845A1 (en) | 2006-08-31 |
| CA2576734C (fr) | 2010-03-16 |
| JP2008506787A (ja) | 2008-03-06 |
| MX2007001118A (es) | 2007-03-15 |
| BRPI0513914A (pt) | 2008-05-20 |
| AU2005280496A1 (en) | 2006-03-09 |
| AR050187A1 (es) | 2006-10-04 |
| EP1771171A1 (fr) | 2007-04-11 |
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